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A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
In conclusion, DhHP-3 has bioactivity of CIRI inhibition through suppression of the ROS-induced apoptosis.PMID:36442518 | DOI:10.1016/j.yexcr.2022.113432
Source: Experimental Cell Research - November 28, 2022 Category: Cytology Authors: Fanwei Meng Junfeng Ke Jinze Li Changhui Zhao Jiaqing Yan Liping Wang Source Type: research

Advances of circRNA-miRNA-mRNA regulatory network in cerebral ischemia/reperfusion injury
Exp Cell Res. 2022 Aug 17:113302. doi: 10.1016/j.yexcr.2022.113302. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke, and its pathophysiological process is more complex. In recent years, the key regulatory roles of non-coding RNA (miRNA, circRNA) and mRNA in the development of IS have attracted more attention. In the process of cerebral ischemia/reperfusion injury, circRNA can regulate nerves, blood vessels and immune system through miRNA/mRNA axis, so as to affect the neurovascular unit of IS. The combination of these noncoding RNAs and mRNAs can be used as non-invasive biomarkers and t...
Source: Experimental Cell Research - August 20, 2022 Category: Cytology Authors: Li Yuan Wei Chen Junjun Xiang Qiumei Deng Yueqiang Hu Junhong Li Source Type: research

Various detailed characteristics of a new enhanced neurotrophic factor secreting rat derived bone marrow mesenchymal stem cells and its preliminary application in rat models of ischemic stroke
Exp Cell Res. 2022 Apr 15:113140. doi: 10.1016/j.yexcr.2022.113140. Online ahead of print.ABSTRACTBecause MSC-NTF has a higher ability to secrete neurotrophic factors, it may have a greater potential than ordinary MSC in clinical applications. At present, research on MSC-NTF mainly focuses on clinical aspects, but its basic research is relatively few. In particular, the research on the comprehensive and detailed characteristics of MSC-NTF is missing. And its in vivo research in animals is also rare. Since the transplantation of human-derived MSC-NTF into rats is cross-species, its survival in the rat and the therapeutic ef...
Source: Experimental Cell Research - April 18, 2022 Category: Cytology Authors: Fenjun Jiang Hui Zhou Yanwen Cheng Zi He Peipei Meng Kaizhou Sun Peishen Wang Xinye Han Lu Wang Mingbin Yang Ningjian Jiang Yang Liu Chunmei Yuan Qing Yang Yihua An Source Type: research

Dl-3-n-butylphthalide Promotes Neurite Outgrowth of Primary Cortical Neurons by Sonic Hedgehog Signaling via Upregulating Gap43.
In this study, we used different methods to investigate the potential effects of NBP on the neurite extension and plasticity of immature and mature primary cortical neurons and explore the underlying mechanisms. Our results demonstrated that in immature and mature cortical neurons, NBP promoted the neurite length and intersection, increased neuritic arborization, elevated numbers of neurite branch and terminal points and improved neurite complexity and plasticity of neuronal development processes. Besides, our data revealed that NBP promoted neurite extension and branching partly by activating Shh signaling pathway via inc...
Source: Experimental Cell Research - December 6, 2020 Category: Cytology Authors: Zhang C, Cui L, He W, Zhang X, Liu H Tags: Exp Cell Res Source Type: research

CTRP9 induces macrophages polarization into M1 phenotype through activating JNK pathway and enhances VSMCs apoptosis in macrophage and VSMCs co-culture system.
Abstract Inflammation plays a critical role in the development of atherosclerosis (AS), which has been identified as a major predisposing factor for stroke. Macrophages and VSMCs are associated with plaque formation and progression. Macrophages can dynamically change into two main functional phenotypes, namely M1 and M2, they can produce either pro-inflammatory or anti-inflammatory factors which may affect the outcome of inflammation. As a member of CTRPs family, CTRP9 has been reported play important protective roles in the cardiovascular system. However, whether CTRP9 can regulate macrophage activation status in...
Source: Experimental Cell Research - July 22, 2020 Category: Cytology Authors: Chen JY, Song CX, Lei SY, Li J, Zuo AJ, Xu D, Guo Y Tags: Exp Cell Res Source Type: research

NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation.
Abstract Ischemic stroke leads to neuronal cell death and induces a cascade of inflammatory signals that results in secondary brain damage. Although constant efforts to develop therapeutic strategies and to reveal the molecular mechanism resulting in the physiopathology of this disease, much still remains unclear. Membrane-bound Toll-like receptors (TLRs) and cytosolic nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) are two major families of pattern recognition receptors that initiate pro-inflammatory signaling pathways. In the present study, we explored the role of NLRP10 in regulating infl...
Source: Experimental Cell Research - February 17, 2020 Category: Cytology Authors: Li ZG, Shui SF, Han XW, Yan L Tags: Exp Cell Res Source Type: research

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF- κB activation associated inflammation and apoptosis.
Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis. Exp Cell Res. 2020 Jan 06;:111818 Authors: Bai X, Zhang YL, Liu LN Abstract Stroke is a leading global cause of mortality and disability. However, the pathogenesis that contributes to stroke has not been fully understood. The tripartite motif (TRIM)-containing proteins usually exhibit essential regulatory roles during various biological processes. TRIM8 is a RING domain-containing E3 ubiquitin ligase, playing crucial roles in regulating inflammation and...
Source: Experimental Cell Research - January 5, 2020 Category: Cytology Authors: Bai X, Zhang YL, Liu LN Tags: Exp Cell Res Source Type: research

Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke.
Abstract The aim of this study was to investigate the role of astrocyte-derived exosomes (AS-Exo) on neuronal damage in ischemic stroke. We isolated astrocytes from 3- to 4-day-old C57BL/6 mice and astrocytes were identified by GFAP immunostaining. Exosomes were obtained from astrocyte supernatant by overspeed centrifugation. For investigating the effect of AS-Exo on the apoptosis of neurons after oxygen and glucose deprivation (OGD), the exosome labeling and uptake by neurons were observed by confocal laser microscopy, then HT-22 cell vitality and apoptosis were determined by Cell Counting Kit-8 (CCK-8) assay a...
Source: Experimental Cell Research - June 19, 2019 Category: Cytology Authors: Pei X, Li Y, Zhu L, Zhou Z Tags: Exp Cell Res Source Type: research

Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling.
CONCLUSIONS: VEGF aggravated BBB disruption after cerebral I/R-induced injury probably by increasing LOC102640519 and HOXC13 through inhibition of ZO-1, Occludin and Claudin-5. PMID: 29842876 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - May 26, 2018 Category: Cytology Authors: Wu L, Ye Z, Pan Y, Li X, Fu X, Zhang B, Li Y, Lin W, Li X, Gao Q Tags: Exp Cell Res Source Type: research

Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF- κB pathway by targeting FOXO3.
Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res. 2018 Apr 28;: Authors: Guo D, Ma J, Li T, Yan L Abstract Dysfunction of the microRNA (miR) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells af...
Source: Experimental Cell Research - April 28, 2018 Category: Cytology Authors: Guo D, Ma J, Li T, Yan L Tags: Exp Cell Res Source Type: research

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