• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Impact of comorbidities on health status measured using the Kansas City Cardiomyopathy Questionnaire in patients with HFrEF and HFpEF
ConclusionsCardiac and non-cardiac comorbidities are common in both HFrEF and HFpEF patients and most are associated with reductions in health status although the impact varied among comorbidities, by the number of comorbidities, and by HF phenotype. Treating/correcting comorbidity is a therapeutic approach that may improve the health status of patients with HF.This article is protected by copyright. All rights reserved.
Source: European Journal of Heart Failure - July 4, 2023 Category: Cardiology Authors: Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham, Akshay S. Desai, Karola S. Jering, Lars K øber, Mikhail N. Kosiborod, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Muthiah Vaduganathan, Michael R. Zile, Pard Tags: Research Article Source Type: research

Predictors and prognostic implications of incident heart failure following the first diagnosis of atrial fibrillation in patients with structurally normal hearts: the Belgrade Atrial Fibrillation Study
Conclusion Underlying co-morbidities or subtle alterations such as mild left atrial dilatation or low-normal LVEF in the absence of overt underlying heart disease are baseline independent risk factors for incident HF during a long-term follow-up. Incident HF was an independent predictor of adverse outcomes in patients initially diagnosed with first-diagnosed AF and structurally normal hearts. These findings could facilitate the identification of AF patients at increased risk for adverse outcomes within the cohort perceived as being at ‘low risk’ given a structurally normal heart on echocardiography.
Source: European Journal of Heart Failure - March 22, 2013 Category: Cardiology Authors: Potpara, T. S., Polovina, M. M., Licina, M. M., Marinkovic, J. M., Lip, G. Y. H. Tags: PROGNOSIS Source Type: research

Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Conclusion While diastolic dysfunction promotes congestion and pulmonary hypertension with stress in HFpEF, reduction in exercise capacity is predominantly related to inadequate CO relative to metabolic needs.
Source: European Journal of Heart Failure - June 21, 2013 Category: Cardiology Authors: Abudiab, M. M., Redfield, M. M., Melenovsky, V., Olson, T. P., Kass, D. A., Johnson, B. D., Borlaug, B. A. Tags: EXERCISE PHYSIOLOGY Source Type: research

Pulmonary vascular response to exercise in symptomatic heart failure with reduced ejection fraction and pulmonary hypertension
ConclusionsEven after thorough decongestion and under continuous afterload reduction, PH secondary to HFrEF is completely reversible in only a minority of patients. Others demonstrate an exercise‐induced PVR increase, associated with impaired right ventricular stroke work, which might be ameliorated by nitric oxide donor support.
Source: European Journal of Heart Failure - December 30, 2014 Category: Cardiology Authors: Frederik H. Verbrugge, Matthias Dupont, Philippe B. Bertrand, Petra Nijst, Lars Grieten, Joseph Dens, David Verhaert, Stefan Janssens, W. H. Wilson Tang, Wilfried Mullens Tags: Original Article Source Type: research

Efficacy and safety of edoxaban compared with warfarin in patients with atrial fibrillation and heart failure: insights from ENGAGE AF‐TIMI 48
ConclusionThe relative efficacy and safety of HDER compared with well‐managed warfarin in AF patients with HF were similar to those without HF.
Source: European Journal of Heart Failure - May 31, 2016 Category: Cardiology Authors: Giulia Magnani, Robert P. Giugliano, Christian T. Ruff, Sabina A. Murphy, Francesco Nordio, Marco Metra, Tiziano Moccetti, Veselin Mitrovic, Minggao Shi, Michele Mercuri, Elliott M. Antman, Eugene Braunwald Tags: Original Article Source Type: research

Impact of atrial fibrillation on rest and exercise haemodynamics in heart failure with mid ‐range and preserved ejection fraction
ConclusionsThe adverse interaction of AF and HFpEF/HFmrEF may be accounted for by an adverse impact on left ventricular systolic function and peripheral oxygen kinetics.
Source: European Journal of Heart Failure - October 11, 2017 Category: Cardiology Authors: David M. Kaye, Frank E. Silvestry, Finn Gustafsson, John G. Cleland, Dirk J. van Veldhuisen, Piotr Ponikowski, Jan Komtebedde, Shane Nanayakkara, Dan Burkhoff, Sanjiv J. Shah Tags: Research Article Source Type: research

A randomised, double ‐blind, placebo‐controlled trial of metformin on myocardial efficiency in insulin‐resistant chronic heart failure patients without diabetes
ConclusionMetformin treatment in non ‐diabetic HFrEF patients improved myocardial efficiency by reducing myocardial oxygen consumption. Measurement of circulating metformin levels differentiated responders from non‐responders. These energy‐sparing effects of metformin encourage further large‐scale investigations in heart failur e patients without diabetes.
Source: European Journal of Heart Failure - December 20, 2019 Category: Cardiology Authors: Anders Hostrup Larsen, Niels Jessen, Helene N ørrelund, Lars Poulsen Tolbod, Hendrik Johannes Harms, Søren Feddersen, Flemming Nielsen, Kim Brøsen, Nils Henrik Hansson, Jørgen Frøkiær, Steen Hvitfeldt Poulsen, Jens Sörensen, Henrik Wigg Tags: Research Article Source Type: research

Impact of left ventricular ejection fraction on clinical outcomes after left main coronary artery revascularization: results from the randomized EXCEL trial
ConclusionIn the EXCEL trial, the composite rate of death, stroke or myocardial infarction at 3  years was significantly higher in patients with HFrEF compared with HFmrEF or preserved LVEF, driven by an increased rate of all‐cause death. No significant differences after PCI vs. CABG were observed among patients with HFrEF, HFmrEF and preserved LVEF. Longer‐term follow‐up could provide important insights on differences in clinical outcomes that might emerge over time.Clinical Trial Registration:ClinicalTrials.gov IDNCT01205776.
Source: European Journal of Heart Failure - February 11, 2020 Category: Cardiology Authors: Daniel J.F.M. Thuijs, Milan Milojevic, Gregg W. Stone, John D. Puskas, Patrick W. Serruys, Joseph F. Sabik, Ovidiu Dressler, Aaron Crowley, Stuart J. Head, A. Pieter Kappetein Tags: Research Article Source Type: research

Central role of left atrial dynamics in limiting exercise cardiac output increase and oxygen uptake in heart failure: insights by cardiopulmonary imaging
ConclusionsIn HF, LA dynamics may play a key role in exercise CO increase due to an impaired forward (left ventricular filling) and backward (right ventricular to pulmonary circulation uncoupling) combination of mechanisms, irrespective of LVEF. The blunted LA strain and LA sra reserve during exercise are associated with a worse cardiopulmonary performance and outcome.
Source: European Journal of Heart Failure - April 29, 2020 Category: Cardiology Authors: Tadafumi Sugimoto, Marta Barletta, Francesco Bandera, Greta Generati, Eleonora Alfonzetti, Marina Rovida, Tomaso Gnecchi Ruscone, Andrea Rossi, Mariantonietta Cicoira, Marco Guazzi Tags: Research Article Source Type: research

Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial
ConclusionsDanicamtiv was well tolerated and improved LV systolic function in patients with HFrEF. A marked improvement in LA volume and function was also observed in patients, consistent with pre ‐clinical findings of direct activation of LA contractility.
Source: European Journal of Heart Failure - June 18, 2020 Category: Cardiology Authors: Adriaan A. Voors, Jean ‐François Tamby, John G. Cleland, Michael Koren, Leslie B. Forgosh, Dinesh Gupta, Lars H. Lund, Albert Camacho, Ravi Karra, Henk P. Swart, Pierpaolo Pellicori, Frank Wagner, Ray E. Hershberger, Narayana Prasad, Robe Tags: Research Article Source Type: research

One ‐year results of the first‐in‐man study investigating the Atrial‐Flow‐Regulator for left‐atrial shunting in symptomatic heart failure patients: the PRELIEVE study
ConclusionsImplantation of the AFR device in HF patients was feasible. No shunt occlusion, stroke or new right HF was observed during the one ‐year follow‐up, with clinical improvements in certain patients.
Source: European Journal of Heart Failure - February 8, 2021 Category: Cardiology Authors: Christina Paitazoglou, Martin W. Bergmann, Ramazan Özdemir, Roman Pfister, Jozef Bartunek, Teoman Kilic, Alexander Lauten, Alexander Schmeisser, Mehdi Zoghi, Stefan Anker, Horst Sievert, Felix Mahfoud, AFR‐PRELIEVE Investigators Tags: Research Article Source Type: research

Pages: 1  2  3  4  5  6  7  8