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Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke mouse model.
This study was to investigate whether SXNI can improve the prognosis of stroke at a subacute phase. Mice with cerebral ischemia-reperfusion injury (CIRI) were established by middle cerebral artery occlusion (MCAO), and drugs or saline were injected by the tail vein every 12 h after reperfusion. The therapeutic effect of SXNI was evaluated by survival rate, modified neurologic severity scores (mNSS), open-field test, locomotive gait patterns, cerebral infarction volume, brain edema and histopathological changes. Subsequently, a combined method of RNA-seq and Ingenuity® Pathway Analysis (IPA) was performed to identify key t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 13, 2020 Category: Drugs & Pharmacology Authors: Li Z, Xiao G, Lyu M, Wang Y, He S, Du H, Wang X, Feng Y, Zhu Y Tags: Biomed Pharmacother Source Type: research

New understanding of the pathogenesis and treatment of stroke-related sarcopenia.
This article reviews the latest progress in the pathogenesis, screening, evaluation and treatment of stroke-related sarcopenia to provide reference for clinical treatment and rehabilitation of stroke. PMID: 32920517 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2020 Category: Drugs & Pharmacology Authors: Li W, Yue T, Liu Y Tags: Biomed Pharmacother Source Type: research

Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
Biomed Pharmacother. 2022 May 20;151:113125. doi: 10.1016/j.biopha.2022.113125. Online ahead of print.ABSTRACTGlutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most initially followed by ion transport protein dysfunction and disruption of ion homeostasis, which in turn leads to impaired glutamate release, reuptake, and excessive N-methyl-D-aspartate receptor (NMDAR) activation, promoting neuronal death. Despite extensive evidence from preclinical studies suggesting that excessive NMDAR stimulation during isc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2022 Category: Drugs & Pharmacology Authors: Zihuan Shen Mi Xiang Chen Chen Fan Ding Yuling Wang Chang Shang Laiyun Xin Yang Zhang Xiangning Cui Source Type: research

Detection of acute ischemic stroke and backtracking stroke onset time via machine learning analysis of metabolomics
Biomed Pharmacother. 2022 Sep 8;155:113641. doi: 10.1016/j.biopha.2022.113641. Online ahead of print.ABSTRACTThe time window from stroke onset is critical for the treatment decision. However, in unknown onset stroke, it is often difficult to determine the exact onset time because of the lack of assessment methods, which can result in controversial and random treatment decisions. Previous studies have shown that serum biomarkers, in addition to imaging assessment, are useful for determining the stroke onset time. However, as yet there are no specific biomarkers or corresponding methodologies that are accurate and effective ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2022 Category: Drugs & Pharmacology Authors: Yiheng Zhang Dayu Zhu Tao Li Xiaoya Wang Lili Zhao Xiaofei Yang Meijuan Dang Ye Li Yulun Wu Ziwei Lu Jialiang Lu Yating Jian Heying Wang Lei Zhang Xiaoyun Lu Ziyu Shen Hong Fan Wenshan Cai Guilian Zhang Source Type: research

The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation
Biomed Pharmacother. 2023 Jul 10;165:115141. doi: 10.1016/j.biopha.2023.115141. Online ahead of print.ABSTRACTIt is widely known that ischemic stroke is the prominent cause of death and disability. To date, neuroinflammation following ischemic stroke represents a complex event, which is an essential process and affects the prognosis of both experimental stroke animals and stroke patients. Intense neuroinflammation occurring during the acute phase of stroke contributes to neuronal injury, BBB breakdown, and worse neurological outcomes. Inhibition of neuroinflammation may be a promising target in the development of new thera...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 12, 2023 Category: Drugs & Pharmacology Authors: Weizhuo Lu Zhiwu Chen Jiyue Wen Source Type: research

Myricetin against myocardial injury in rat heat stroke model.
CONCLUSIONS: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel prevention therapeutic for heat stroke. PMID: 32371315 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2020 Category: Drugs & Pharmacology Authors: Lin X, Lin CH, Liu R, Li C, Jiao S, Yi X, Walker MJ, Xu XM, Zhao T, Huang PC, Sun G Tags: Biomed Pharmacother Source Type: research

QiShen YiQi and its components attenuate acute thromboembolic stroke and carotid thrombosis by inhibition of CD62P/PSGL-1-mediated platelet-leukocyte aggregate formation
CONCLUSION: QSYQ and YQ/HX components attenuated thromboembolic stroke and carotid thrombosis by decreasing PLA formation via inhibiting CD62P/PSGL-1 expressions. This study shed a new light on the prevention of thromboembolic stroke.PMID:36738500 | DOI:10.1016/j.biopha.2023.114323
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 4, 2023 Category: Drugs & Pharmacology Authors: Mingxing Yu Guangxu Xiao Linhong Han Li Peng Huanyi Wang Shuang He Ming Lyu Yan Zhu Source Type: research

Synergistic effect of mild hypothermia and the Notch inhibitor DAPT against post stroke seizures.
Abstract Seizure is a serious complication of stroke, indicating poor prognosis. Notch signaling is associated with neuronal activity. Inhibition of Notch signaling suppresses seizure activity induced by kainic acid. The present study investigated the effect of the Notch inhibitor, DAPT, alone or in combination with mild hypothermia, on post-stroke seizures. A global cerebral ischemia (GCI) model was performed in Sprague Dawley (SD) male rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges. Without any intervention, seizures occurred intensively ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2017 Category: Drugs & Pharmacology Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Tags: Biomed Pharmacother Source Type: research

Recovery of post-stroke cognitive and motor deficiencies by Shuxuening injection via regulating hippocampal BDNF-mediated Neurotrophin/Trk Signaling
In this study, a nonfatal stroke model was constructed in mice by a modified middle cerebral artery occlusion (MCAO) procedure, allowing an extended recovery period up to 28 days. The extended MCAO model successfully mimicked phenotypes of a recovery phase post-stroke, including locomotor motor and cognitive deficiencies, which were effectively improved after Shuxuening injection (SXNI) treatment. Tissue slices staining showed that SXNI repaired brain injury and reduced neuronal apoptosis, especially in the hippocampus CA3 region. Transcriptomics sequencing study revealed 565 differentially expressed genes (DEGs) in the is...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 19, 2021 Category: Drugs & Pharmacology Authors: Zhixiong Li Huanyi Wang Guangxu Xiao Hongxia Du Shuang He Yuxin Feng Boli Zhang Yan Zhu Source Type: research

Qishen Yiqi Dropping Pill facilitates post-stroke recovery of motion and memory loss by modulating ICAM-1-mediated neuroinflammation
CONCLUSION: QSYQ effectively accelerates the recovery of motor impairment and memory loss in rats after stroke via downregulation of ICAM-1-mediated neuroinflammation, and rosmarinic acid is one of its main active components.PMID:35772377 | DOI:10.1016/j.biopha.2022.113325
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 30, 2022 Category: Drugs & Pharmacology Authors: Xinyan Liu Guangxu Xiao Yule Wang Ting Shang Zhixiong Li Huanyi Wang Lihua Pu Shuang He Rui Shao John Owoicho Orgah Yan Zhu Source Type: research

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