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Source: Behavioural Brain Research

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Total 143 results found since Jan 2013.

Spatial attention in children with perinatal stroke
Behav Brain Res. 2021 Oct 1:113614. doi: 10.1016/j.bbr.2021.113614. Online ahead of print.ABSTRACTSpatial neglect is a common feature of right hemisphere damage in adults, but less is known about spatial inattention following early brain damage. We used a Posner-based cueing task to examine hemispatial neglect and aspects of attention in children with perinatal stroke in either left (LH) or right hemisphere (RH) and controls. A visual perception task assessed the speed of visual perception. A spatial attention cueing task (the E-task) measured the ability to discriminate the direction of a target stimulus ("E"), when prese...
Source: Behavioural Brain Research - October 4, 2021 Category: Neurology Authors: Timothy Adamos Leanne Chukoskie Jeanne Townsend Doris Trauner Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Specific stimulation of PV < sup > + < /sup > neurons at early stage ameliorates prefrontal ischemia-induced spatial working memory impairment
Behav Brain Res. 2021 Aug 3;414:113511. doi: 10.1016/j.bbr.2021.113511. Online ahead of print.ABSTRACTPrefrontal ischemia can cause impairments in learning and memory, executive functions and cognitive flexibility. However, the related cellular mechanisms at the early stage are still elusive. The present study used ischemic stroke in medial prefrontal cortex and systemically investigated the electrophysiological changes of the parvalbumin (PV+) interneurons 12 h post ischemia. We found that Ih and the related voltage sags in PV+ interneurons are downregulated post ischemia, which correlates with hyperpolarization of the me...
Source: Behavioural Brain Research - August 6, 2021 Category: Neurology Authors: Lin Chen Jun Hu Jiankun Mu Chao Li Guang-Yan Wu Chao He Youhong Xie Jian-Ning Ye Source Type: research

Effectiveness and mechanisms of enriched environment in post-stroke cognitive impairment
Behav Brain Res. 2021 May 11:113357. doi: 10.1016/j.bbr.2021.113357. Online ahead of print.ABSTRACTPost-stroke cognitive impairment (PSCI) is one of the most common complications of stroke, it is also an important reason for the poor prognosis in stroke patients with motor and speech dysfunction. Enriched Environment (EE), a novel and easy-to-implement rehabilitation treatment strategy, is thought to be a potential intervention for PSCI recently. In this paper, we review the therapeutic effects and related mechanisms of EE in PSCI from the level of animal research and clinical application. Besides, we further discuss the a...
Source: Behavioural Brain Research - May 14, 2021 Category: Neurology Authors: Mei Yuan Yi-Sha Guo Yu Han Zhen-Kun Gao Xin-Ya Shen Xia Bi Source Type: research

Effect of NEUROG3 Polymorphism Rs144643855 on Regional Spontaneous Brain Activity in Major Depressive Disorder
CONCLUSION: These findings suggest a potential relationship between rs144643855 variations and altered frontal brain activity in MDD. NEUROG3 may play an important role in the neuropathophysiology of MDD.PMID:33878431 | DOI:10.1016/j.bbr.2021.113310
Source: Behavioural Brain Research - April 20, 2021 Category: Neurology Authors: Zhuoliang Hou Xiaoyun Liu Wenhao Jiang Zhenghua Hou Yingying Yin Chunming Xie Haisan Zhang Hongxing Zhang Zhijun Zhang Yonggui Yuan Source Type: research

Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Abstract Post-stroke depression(PSD) is a common complication and associates with poor physical recovery, low quality of life and high mortality after cerebral infarction. However, the pathogenesis of PSD have not been elucidated thoroughly now, and there is a lack of effective therapy in clinic. It reported that Saikosaponin A, one of the main constituents from Chinese herb Bupleurum chinense, has pharmacological activity in anti-depression. Thus, this study aimed to elucidate the potential effects and mechanisms of Saikosaponin A on the depression-like behavior after cerebral ischemic injury in rats. The rat mod...
Source: Behavioural Brain Research - January 22, 2021 Category: Neurology Authors: Wang AR, Mi LF, Zhang ZL, Hu MZ, Zhao ZY, Liu B, Li YB, Zheng S Tags: Behav Brain Res Source Type: research