Filtered By:
Source: Behavioural Brain Research
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 143 results found since Jan 2013.
Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression
Conclusion: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.PMID:36116735 | DOI:10.1016/j.bbr.2022.114117
Source: Behavioural Brain Research - September 18, 2022 Category: Neurology Authors: Xiaoju Wang Peng Xia Jiulong Song Ting Yang Changjun Yu Kai Cheng Anliang Chen Xueping Li Source Type: research
CRS induces depression-like behavior after MCAO in rats possibly by activating p38 MAPK
Behav Brain Res. 2022 Sep 10:114104. doi: 10.1016/j.bbr.2022.114104. Online ahead of print.ABSTRACTPost-stroke depression (PSD) is a common neuropsychiatric complication of stroke, which seriously affects the quality of life and prognosis of patients. Nevertheless, the pathogenesis of PSD remains unclear. In our study, a PSD rat model was established by chronic restraint stress (CRS) combined with middle cerebral artery occlusion (MCAO). Depressive and anxiety-like behaviors were tested, as well as Neuronal loss and Apoptosis. The expression of synapse and p38 MAPK signaling pathway -relevant proteins was detected. Our dat...
Source: Behavioural Brain Research - September 13, 2022 Category: Neurology Authors: Lingyun Zhi Fuping Zhang Huanhuan Liu Xinhui Jiang Yunfei Zhang Qianling Yang Xinyue Zhang Mengke Liu Zhaohui Zhang Jinggui Song Source Type: research
Adipose-derived mesenchymal stem cells reduced transient cerebral ischemia injury by modulation of inflammatory factors and AMPK signaling
In this study, by releasing the clips, the reperfusion period was extended to 96hours, and two hours after cerebral ischemia, animals received adipose-derived MSCs. MSCs were isolated from the inguinal fat pads of rats and injected into two-vessel occlusion (2VO) rats 1hour after ischemia induction. Ninety-six hours after 2VO induction, behavioral and molecular tests were assessed. Adipose-derived MSCs treatment improves neurological scores, passive avoidance memory, and novel object recognition tests in the 2VO model compared to 2VO rats (P<0.001). MSCs treatment decreased TNF-α (P<0.01) and IL-6 (P<0.01) and ap...
Source: Behavioural Brain Research - July 9, 2022 Category: Neurology Authors: Mina Ranjbaran Reyhaneh Vaali Zahra Yaghoobi Fardin Sehati Vida Jashn Sevda Mahdipour Kolur Fariba Akhondzadeh Ghorbangol Ashabi Source Type: research
Effects of wheel-running on anxiety and depression-relevant behaviours in the MCAO mouse model of stroke: moderation of brain-derived neurotrophic factor and serotonin receptor gene expression
We report that MCAO induced hypo-locomotion and anhedonia-related behaviours, with some improvements conferred by wheel-running. Serotonin transporter gene expression was increased in the MCAO hippocampus and frontal cortex, but this increase remained despite wheel-running. Wheel-running associated up-regulation of BDNF gene expression was unaffected in MCAO mice, reflecting conservation of key neuroplasticity molecular pathways. Taken together, our results highlight the need for further research into serotonergic modulation of the affective symptoms of stroke.PMID:35777551 | DOI:10.1016/j.bbr.2022.113983
Source: Behavioural Brain Research - July 1, 2022 Category: Neurology Authors: Vanessa H Brait Katherine A Jackman Terence Y Pang Source Type: research
Preserved Intersegmental Coordination During Locomotion after Cervical Spinal Cord Injury in Common Marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research
Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research
Preserved Intersegmental Coordination During Locomotion after Cervical Spinal Cord Injury in Common Marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research
Impact of MRI on decision-making in ICU patients with disorders of consciousness
CONCLUSION: MRI results changed decision-making in 3 of 4 ICU patients, but radiological findings were not predictive of clinical decision-making. This highlights the need to better understand the effects of neuroimaging on management decisions. How MRI influences decision-making in the ICU is an important avenue for research to improve acute DoC management.PMID:34973968 | DOI:10.1016/j.bbr.2021.113729
Source: Behavioural Brain Research - January 2, 2022 Category: Neurology Authors: Simon S Albrechtsen Robert G C Riis Moshgan Amiri Gry Tanum Ove Bergdal Morten Blaabjerg Claus Z Simonsen Daniel Kondziella Source Type: research
Different training patterns at recovery stage improve cognitive function in ischemic stroke rats through regulation of the axonal growth inhibitor pathway
This study investigated the effects of SRT and RWE, at the recovery stage, on the cognitive function of transient middle cerebral artery occlusion (tMCAO) rats and explored their association with NgR1/Rho-A/ROCK/LOTUS/LGI1 signaling. Adult Sprague-Dawley rats (n = 55) were divided into four groups after pretraining: SRT, RWE, tMCAO, and Sham. Rats were subjected to modified neurological severity score (mNSS) measurements and forelimb grip strength and the Morris water maze tests. Using immunofluorescence and western blotting, we evaluated axonal growth inhibitor expression in the peri-infarct cortex on days 28 and 56 after...
Source: Behavioural Brain Research - December 31, 2021 Category: Neurology Authors: Chao Li Ruifang Sun Jiemei Chen Jiena Hong Ju Sun Yan Zeng Xue Zhang Zulin Dou Hongmei Wen Source Type: research
