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Human bone marrow mesenchymal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.
In conclusion, human BMMSCs did not improve functional recovery in MCAO rats despite effective initial homing to the ischemic hemisphere and enhanced angiogenesis, when strict behavioral tests not affected by repeated testing and compensation were utilized. PMID: 24177208 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - October 28, 2013 Category: Neurology Authors: Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J Tags: Behav Brain Res Source Type: research

Assessment of behavioral flexibility after middle cerebral artery occlusion in mice.
In conclusion, our operant-based task revealed a long-lasting behavioral flexibility deficit after MCAO in mice. PMID: 24157337 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - October 21, 2013 Category: Neurology Authors: Linden J, Fassotte L, Tirelli E, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research

Impaired executive function following ischemic stroke in the rat medial prefrontal cortex.
Abstract Small (lacunar) infarcts frequently arise in frontal and midline thalamic regions in the absence of major stroke. Damage to these areas often leads to impairment of executive function likely as a result of interrupting connections of the prefrontal cortex. Thus, patients experience frontal-like symptoms such as impaired ability to shift ongoing behavior and attention. In contrast, executive dysfunction has not been demonstrated in rodent models of stroke, thereby limiting the development of potential therapies for human executive dysfunction. Male Sprague-Dawley rats (n=40) underwent either sham surgery o...
Source: Behavioural Brain Research - October 18, 2013 Category: Neurology Authors: Cordova CA, Jackson D, Langdon KD, Hewlett KA, Corbett D Tags: Behav Brain Res Source Type: research

Quantitative gait analysis of long-term locomotion deficits in classical unilateral striatal intracerebral hemorrhage rat model.
Abstract Gait analysis is a systematic collection of quantitative information on bodily movements during locomotion. Gait analysis has been employed clinically in stroke patients for their rehabilitation planning. In animal studies, gait analysis has been employed for the assessment their locomotive disturbances in ischemic stroke, spinal cord injury and Parkinson's disease. The aims of the work reported here were to identify the gait parameters, collected from the computer-generated CatWalk System, that change after unilateral intracerebral hemorrhage (ICH) in the acute stage and long term up to 56 days post-ICH....
Source: Behavioural Brain Research - October 11, 2013 Category: Neurology Authors: Liu Y, Ao LJ, Lu G, Leong E, Liu Q, Wang XH, Zhu XL, Sun TF, Fei Z, Jiu T, Hu X, Poon WS Tags: Behav Brain Res Source Type: research

Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia.
Abstract Willed-movement (WM) training has been implicated in the promotion of motor function in human stroke survivors and focal ischemic rats. However, the molecular basis of changes in synaptic transmission following WM training remains unclear. In addition, studies examining the influence of rehabilitative training, such as skilled motor learning, on long-term depression (LTD) of synapses in the primary motor cortex have produced conflicting results. To identify the possible effects of willed movement on motor recovery, on expression of the protein interacting with C kinase 1 protein (PICK1), and on PICK1 rela...
Source: Behavioural Brain Research - September 1, 2013 Category: Neurology Authors: Tang Q, Tan L, Yang X, Shen Q, Huang X, Wang G, Chen H, Nie J, Li S, Wu L Tags: Behav Brain Res Source Type: research

Subcutaneous daidzein administration enhances recovery of skilled ladder rung walking performance following stroke in rats.
Abstract Stroke is a devastating event which can result in permanent disability. Due to the lack of treatments available for use after stroke, compounds which work to limit cell loss, reduce behavioral deficits, and enhance recovery of function are needed. The isoflavone daidzein has been demonstrated to be neuroprotective when fed to rats beginning prior to stroke. Herein, we tested whether subcutaneous delivery of daidzein beginning at the time of stroke reduced injury and/or enhanced functional recovery over 14 days after stroke. Baseline performance on the skilled ladder rung walking task was recorded immediat...
Source: Behavioural Brain Research - August 27, 2013 Category: Neurology Authors: Stout JM, Knapp AN, Banz WJ, Wallace DG, Cheatwood JL Tags: Behav Brain Res Source Type: research

Post-stroke protection from maladaptive effects of learning with the non-paretic forelimb by bimanual home cage experience in C57BL/6 mice.
Abstract Behavioral experience, in the form of skilled limb use, has been found to impact the structure and function of the central nervous system, affecting post-stroke behavioral outcome in both adaptive and maladaptive ways. Learning to rely on the less-affected, or non-paretic, body side is common following stroke in both humans and rodent models. In rats, it has been observed that skilled learning with the non-paretic forelimb following ischemic insult leads to impaired or delayed functional recovery of the paretic limb. Here we used a mouse model of focal motor cortical ischemic injury to examine the effects...
Source: Behavioural Brain Research - June 8, 2013 Category: Neurology Authors: Kerr AL, Wolke ML, Bell JA, Jones TA Tags: Behav Brain Res Source Type: research

Low-speed treadmill running exercise improves memory function after transient middle cerebral artery occlusion in rats.
Abstract Physical exercise may enhance the recovery of impaired memory function in stroke rats. However the appropriate conditions of exercise and the mechanisms underlying these beneficial effects are not yet known. Therefore, the purpose of this study was to investigate the effect exercise intensity on memory function after cerebral infarction in rats. The animals were subjected to middle cerebral artery occlusion (MCAO) for 90min to induce stroke and were randomly assigned to four groups; Low-Ex, High-Ex, Non-Ex and Sham. On the fourth day after surgery, rats in the Low-Ex and High-Ex groups were forced to exer...
Source: Behavioural Brain Research - December 21, 2012 Category: Neurology Authors: Shimada H, Hamakawa M, Ishida A, Tamakoshi K, Nakashima H, Ishida K Tags: Behav Brain Res Source Type: research

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