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Source: Behavioural Brain Research

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Total 143 results found since Jan 2013.

Effects of thalamic hemorrhagic lesions on explicit and implicit learning during the acquisition and retrieval phases in an animal model of central post-stroke pain.
Abstract Hemorrhagic stroke has many symptoms, including central pain, learning and memory impairments, motor deficits, language problems, emotional disturbances, and social maladjustment. Lesions of the ventral basal complex (VBC) of the thalamus elicit thermal and mechanical hyperalgesia, forming an animal model of central post-stroke pain (CPSP). However, no research has yet examined the involvement of learning and memory in CPSP using an animal model. The present study examined whether VBC lesions affect motor function, conditioned place preference (CPP; implicit memory), and spatial learning (explicit memory)...
Source: Behavioural Brain Research - September 24, 2016 Category: Neurology Authors: Wang CC, Shih HC, Shyu BC, Huang AC Tags: Behav Brain Res Source Type: research

Transcranial direct current stimulation (tDCS) to improve naming ability in post-stroke aphasia: A critical review.
CONCLUSIONS: Several methodological issues have been identified in pre-efficacy studies that pose challenges in determining whether tDCS is a beneficial adjunct to behavioral aphasia therapy. Future studies need to improve the quality of the methods used to investigate the effect of tDCS for anomia. PMID: 28572057 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - May 29, 2017 Category: Neurology Authors: ALHarbi MF, Armijo-Olivo S, Kim ES Tags: Behav Brain Res Source Type: research

Auditory neglect in children following perinatal stroke.
Abstract Auditory neglect has been found in adults with right hemisphere focal brain lesions following strokes. Visual and tactile neglect has been found in children following both left and right hemisphere lesions resulting from perinatal strokes. The present cross-sectional study assessed auditory neglect in children with early unilateral brain damage from perinatal stroke. Twenty-six children with perinatal stroke and matched controls participated. All were asked to identify the location of a pure tone presented in left or right auditory fields. We found that children who had experienced left hemisphere perinat...
Source: Behavioural Brain Research - June 25, 2018 Category: Neurology Authors: Martin K, Trauner DA Tags: Behav Brain Res Source Type: research

Effectiveness and mechanisms of enriched environment in post-stroke cognitive impairment
Behav Brain Res. 2021 May 11:113357. doi: 10.1016/j.bbr.2021.113357. Online ahead of print.ABSTRACTPost-stroke cognitive impairment (PSCI) is one of the most common complications of stroke, it is also an important reason for the poor prognosis in stroke patients with motor and speech dysfunction. Enriched Environment (EE), a novel and easy-to-implement rehabilitation treatment strategy, is thought to be a potential intervention for PSCI recently. In this paper, we review the therapeutic effects and related mechanisms of EE in PSCI from the level of animal research and clinical application. Besides, we further discuss the a...
Source: Behavioural Brain Research - May 14, 2021 Category: Neurology Authors: Mei Yuan Yi-Sha Guo Yu Han Zhen-Kun Gao Xin-Ya Shen Xia Bi Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Effects of Repetitive Transcranial Magnetic Stimulation on Post-Stroke Patients with Cognitive Impairment: A Systematic Review and Meta-analysis
CONCLUSION: rTMS provides a non-invasive and effective technique for the treatment of post-stroke patients with cognitive impairment.PMID:36442646 | DOI:10.1016/j.bbr.2022.114229
Source: Behavioural Brain Research - November 28, 2022 Category: Neurology Authors: Kun-Peng Li Jie Sun Cai-Qin Wu Xu-Fei An Jia-Jia Wu Mou-Xiong Zheng Xu-Yun Hua Jian-Guang Xu Source Type: research

Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
This study was undertaken to explore the potential mechanisms underlying the neuroprotective effects of BMRMNCs in middle cerebral artery occlusion (MCAO) rat model. Rats were intravenously pre-treated with 5-FU and BMRMNCs were collected at different time points. The contents of growth factors in the supernatant and CXCR4 expression were detected by ELISA and flow cytometry, respectively. MCAO was introduced to rats, and BMMNCs and BMRMNCs collected at 7 days after 5-FU pre-treatment were independently transplanted via the tail vein 24h later. The neurological function was evaluated before cell transplantation and at 24h,...
Source: Behavioural Brain Research - July 25, 2015 Category: Neurology Authors: Li Y, Mao WW, Zhang CG, Wan L, Jing CH, Hua XM, Li ST, Cheng J Tags: Behav Brain Res Source Type: research

Spinal or Cortical direct current stimulation: Which is the best? Evidence from apraxia of speech in post-stroke aphasia.
Abstract To date, new advances in technology have already shown the effectiveness of non-invasive brain stimulation and, in particular, of transcranial direct current stimulation (tDCS), in enhancing language recovery in post-stroke aphasia. More recently, it has been suggested that the stimulation over the spinal cord improves the production of words associated to sensorimotor schemata, such as action verbs. Here, for the first time, we present evidence that transpinal direct current stimulation (tsDCS) combined with a language training is efficacious for the recovery from speech apraxia, a motor speech disorder ...
Source: Behavioural Brain Research - November 15, 2020 Category: Neurology Authors: Pisano F, Caltagirone C, Incoccia C, Marangolo P Tags: Behav Brain Res Source Type: research

Ramelteon improves blood-brain barrier of focal cerebral ischemia rats to prevent post-stroke depression via upregulating occludin
This study explored the effects of ramelteon with prophylactic administration on blood-brain barrier in rats with middle cerebral artery occlusion (MCAO) and the oxygen-glucose deprivation/reperfusion (OGD/R) bEnd.3 cells and found that ramelteon pretreatment improved the depressive-like behaviors and decreased infarct area in MCAO rats. Also, this study found ramelteon pretreatment improved viability and inhibited permeability in OGD/R cells. In addition, this study found that MCP-1, TNF-α, and IL-1 levels were raised in the MCAO rats and that occludin protein and mRNA levels were decreased in the MCAO and the OGD/R mode...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Xuchen Qi Ziqi Tang Xian Shao Zhaowei Wang Mengyun Li Xiaobing Zhang Lingyan He Jianli Wang Xuebin Yu Source Type: research

DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway
This study aimed to investigate the effect of on apoptosis in primary cortical neurons exposed to oxygen-glucose deprivation and reoxygenation (OGD/R) and mice suffered from transient middle cerebral artery occlusion and reperfusion (MCAO/R). The results showed that DUSP10 overexpression improved survival and reduced apoptosis in neurons subjected to OGD/R, which was manifested by decreased apoptotic proteins (cleaved caspase 3 and bax) and TUNEL+ cells, as well as increased the anti-apoptotic protein (bcl-2). DUSP10 overexpression inhibited the p38/JNK signaling pathway after OGD/R treatment, whilst DUSP10 knockdown had o...
Source: Behavioural Brain Research - May 10, 2023 Category: Neurology Authors: Ni-Na Song Ying Zhao Chuang Sun Jun Zhang Guang-Jun Lin Xiao-Wei Yin Chun-Ye Ma Source Type: research

Corrigendum to "The right hemisphere is dominant in organization of visual search-A study in stroke patients" Behav. Brain Res. 304 (2016) 71-79.
PMID: 27923509 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - December 2, 2016 Category: Neurology Authors: Ten Brink AF, Biesbroek JM, Kuijf HJ, Van der Stigchel S, Oort Q, Visser-Meily JM, Nijboer TC Tags: Behav Brain Res Source Type: research