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Source: Behavioural Brain Research

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Total 143 results found since Jan 2013.

Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke.
In this study, we evaluated the applicability of forepaw grip strength and automated von Frey tactile sensitivity tests to assess forelimb dysfunction in mice following photothrombosis in the sensorimotor cortex, and compared them with two well-established tests, grid-walking and cylinder, for up to 21days after stroke. Our results indicate that the length of time required to conduct the two new tests is comparable to that of the grid-walking and cylinder tests, however the data from the new tests is obtained and ready for analysis upon completion of the testing session. In addition, our observations indicate that the auto...
Source: Behavioural Brain Research - September 8, 2017 Category: Neurology Authors: Alamri FF, Shoyaib AA, Biggers A, Jayaraman S, Guindon J, Karamyan VT Tags: Behav Brain Res Source Type: research

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke.
Abstract Stroke leads to devastating outcomes including impairments of sensorimotor and cognitive function that may be long lasting. New intervention strategies are needed to overcome the long-lasting effects of ischemic injury. Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred chemical preconditioning and neuroprotection against stroke. The purpose of the current study was to determine whether the preconditioning can lead to functional improvements after stroke (done by transient middle cerebral artery occlusion). After 4 weeks of MICA feeding, half the rats underw...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Sumien N, Huang R, Chen Z, Vann PH, Wong JM, Li W, Yang S, Forster M, Yan LJ Tags: Behav Brain Res Source Type: research

Motor deficit in the mouse ferric chloride-induced distal middle cerebral artery occlusion model of stroke.
In this study, we reproduced the recently developed model and expanded its characterization by thorough evaluation of blood supply, cerebral infarction, and motor function in adult male and female mice up to 14 days after stroke. Our observations indicate near complete interruption of blood flow in the distal MCA shortly after application of 20% ferric chloride over the artery through a cranial window, which remained occluded for at least 4 hours. As expected, infarction of the brain tissue, documented by TTC and hematoxylin stains, was restricted to the cerebral cortex. We also systematically evaluated motor impairment ...
Source: Behavioural Brain Research - December 4, 2019 Category: Neurology Authors: Syeara N, Alamri FF, Jayaraman S, Lee P, Karamyan ST, Arumugam TV, Karamyan VT Tags: Behav Brain Res Source Type: research

Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research

Impaired executive function following ischemic stroke in the rat medial prefrontal cortex.
Abstract Small (lacunar) infarcts frequently arise in frontal and midline thalamic regions in the absence of major stroke. Damage to these areas often leads to impairment of executive function likely as a result of interrupting connections of the prefrontal cortex. Thus, patients experience frontal-like symptoms such as impaired ability to shift ongoing behavior and attention. In contrast, executive dysfunction has not been demonstrated in rodent models of stroke, thereby limiting the development of potential therapies for human executive dysfunction. Male Sprague-Dawley rats (n=40) underwent either sham surgery o...
Source: Behavioural Brain Research - October 18, 2013 Category: Neurology Authors: Cordova CA, Jackson D, Langdon KD, Hewlett KA, Corbett D Tags: Behav Brain Res Source Type: research

Impact of estrogen receptor beta activation on functional recovery after experimental stroke.
Abstract Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 ...
Source: Behavioural Brain Research - January 6, 2014 Category: Neurology Authors: Madinier A, Wieloch T, Olsson R, Ruscher K Tags: Behav Brain Res Source Type: research

Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke.
In this study, we investigated whether EGCG treatment in the acute phase of ischemic stroke can promote angiogenesis in a mouse model of transient middle cerebral artery occlusion (MCAO). We assessed neurological function with modified neurologic severity score (mNSS) test, infarct volume by Nessl staining, angiogenesis and oxidative stress by immunofluorescence analysis, intravital lectin perfusion analysis, western blot analysis and enzyme-linked immunosorbent assay (ELISA). In order to explore the role of Nrf2 in the angiogenesis of MCAO+EGCG-treated mice, we used MAPK/ERK inhibitor PD98059 to block the activation of Nr...
Source: Behavioural Brain Research - December 28, 2016 Category: Neurology Authors: Bai Q, Yang X, Lyu Z, Pan Z, Lou J, Dong T Tags: Behav Brain Res Source Type: research

Functions of subventricular zone neural precursor cells in stroke recovery.
Abstract The proliferation and ectopic migration of neural precursor cells (NPCs) in response to ischemic brain injury was first reported two decades ago. Since then, studies of brain injury-induced subventricular zone cytogenesis, primarily in rodent models, have provided insight into the cellular and molecular determinants of this phenomenon and its modulation by various factors. However, despite considerable correlational evidence-and some direct evidence-to support contributions of NPCs to behavioral recovery after stroke, the causal mechanisms have not been identified. Here we discuss the subventricular zone ...
Source: Behavioural Brain Research - September 3, 2019 Category: Neurology Authors: Williamson MR, Jones TA, Drew MR Tags: Behav Brain Res Source Type: research

Effects of wheel-running on anxiety and depression-relevant behaviours in the MCAO mouse model of stroke: moderation of brain-derived neurotrophic factor and serotonin receptor gene expression
We report that MCAO induced hypo-locomotion and anhedonia-related behaviours, with some improvements conferred by wheel-running. Serotonin transporter gene expression was increased in the MCAO hippocampus and frontal cortex, but this increase remained despite wheel-running. Wheel-running associated up-regulation of BDNF gene expression was unaffected in MCAO mice, reflecting conservation of key neuroplasticity molecular pathways. Taken together, our results highlight the need for further research into serotonergic modulation of the affective symptoms of stroke.PMID:35777551 | DOI:10.1016/j.bbr.2022.113983
Source: Behavioural Brain Research - July 1, 2022 Category: Neurology Authors: Vanessa H Brait Katherine A Jackman Terence Y Pang Source Type: research

H2S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke.
In this study, we established four-vessel occlusion model in rats with cerebral ischemia. We found that NaHS (28mmol/kg, intraperitoneally, for 7 days before ischemia), donor of H2S, significantly shortened the distance and time of loading onto the hidden platform in the positioning navigation process, decreased the latency in the space exploration process when cognitive testing with Morris water maze was performed during ischemic stroke in rats. NaHS also significantly shortened latency and reduced the number of errors in the platform diving experiment. The survival rate of neurons in the CA1 area of the hippocampus and t...
Source: Behavioural Brain Research - April 23, 2014 Category: Neurology Authors: Wen X, Qi D, Sun Y, Huang X, Zhang F, Wu J, Fu Y, Du Y, Dong H, Liu Y, Liu H, Song Y Tags: Behav Brain Res Source Type: research

Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole.
Abstract We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left middle cerebral artery occlusion (MCAO) and CMS after MCAO (MCAO+CMS) in mice. In all depressant screening tests involving open field, sucrose preference, forced swim and Morris water maze test, MCAO+CMS mice showed more significant depressive behaviors than MCAO mice. MCAO+CMS mice also showed distinct deficits in forced swim ...
Source: Behavioural Brain Research - April 3, 2015 Category: Neurology Authors: Kim YR, Kim HN, Pak ME, Ahn SM, Hong KH, Shin HK, Choi BT Tags: Behav Brain Res Source Type: research

The right hemisphere is dominant in organization of visual search - a study in stroke patients.
Abstract Cancellation tasks are widely used for diagnosing attentional deficits in stroke patients. A disorganized fashion of target cancellation has been hypothesized to reflect disturbed spatial exploration. In the current study we aimed to examine which lesion locations result in disorganized visual search during cancellation tasks, in order to determine which brain areas are involved in search organisation. A computerized shape cancellation task was administered in 78 stroke patients. As an index for search organization, the amount of intersections of paths between consecutive crossed targets was computed (i.e...
Source: Behavioural Brain Research - February 11, 2016 Category: Neurology Authors: Ten Brink AF, Matthijs Biesbroek J, Kuijf HJ, Van der Stigchel S, Oort Q, Visser-Meily JM, Nijboer TC Tags: Behav Brain Res Source Type: research

Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke.
Abstract Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. Th...
Source: Behavioural Brain Research - March 17, 2016 Category: Neurology Authors: Linden J, Beeck LV, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research

Increased ventral premotor cortex recruitment after arm training in an fMRI study with subacute stroke patients.
Abstract To investigate therapy associated changes in the cerebral representation of movement after stroke, we used functional magnetic resonance imaging (fMRI) during an active and a passive motor task for the affected and unaffected hand before and after a three week comprehensive hand motor training. Twelve patients in the subacute phase from 2 to 9 weeks after mild to moderate motor stroke were recruited. During fMRI, the active task comprised fist clenching, which was precisely controlled for motor performance by visual feedback of force and frequency. The passive task consisted of wrist flexion-extension of ...
Source: Behavioural Brain Research - April 21, 2016 Category: Neurology Authors: Horn U, Roschka S, Eyme K, Walz AD, Platz T, Lotze M Tags: Behav Brain Res Source Type: research