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Specialty: Allergy & Immunology
Source: Advances in Immunology
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Total 1628 results found since Jan 2013.
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
Regulation of gasdermins in pyroptosis and cytokine release
Adv Immunol. 2023;158:75-106. doi: 10.1016/bs.ai.2023.03.002. Epub 2023 Apr 11.ABSTRACTGasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys res...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Sai Li Syrena Bracey Zhonghua Liu Tsan Sam Xiao Source Type: research
RIG-I-like receptors: Molecular mechanism of activation and signaling
Adv Immunol. 2023;158:1-74. doi: 10.1016/bs.ai.2023.03.001. Epub 2023 May 9.ABSTRACTDuring RNA viral infection, RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and belong to a subgroup of superfamily 2 Helicase/ATPase that is preferably activated by double-stranded RNA. RLRs are significantly different in gene architecture, RNA ligand preference, activation, and molecular functions. As switchable macromolecula...
Source: Advances in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Jie Zheng Wenjia Shi Ziqun Yang Jin Chen Ao Qi Yulin Yang Ying Deng Dongyuan Yang Ning Song Bin Song Dahai Luo Source Type: research
