The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

The multi-faceted roles of TGF- β in regulation of immunity to infection
Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, ...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Rick M Maizels Source Type: research

Follicular lymphoma dynamics
Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.ABSTRACTFollicular lymphoma (FL) is an indolent yet challenging disease. Despite a generally favorable response to immunochemotherapy regimens, a fraction of patients does not respond or relapses early with unfavorable prognosis. For the vast majority of those who initially respond, relapses will repeatedly occur with increasing refractoriness to available treatments. Addressing the clinical challenges in FL warrants deep understanding of the nature of treatment-resistant FL cells seeding relapses, and of the biological basis of early disease pr...
Source: Advances in Immunology - June 28, 2021 Category: Allergy & Immunology Authors: Pierre Milpied Anita K Gandhi Guillaume Cartron Laura Pasqualucci Karin Tarte Bertrand Nadel Sandrine Roulland Source Type: research

Thymoproteasome optimizes positive selection of CD8 < sup > + < /sup > T cells without contribution of negative selection
Adv Immunol. 2021;149:1-23. doi: 10.1016/bs.ai.2021.03.001. Epub 2021 May 1.ABSTRACTFunctionally competent and self-tolerant T cell repertoire is shaped through positive and negative selection in the cortical and medullary microenvironments of the thymus. The thymoproteasome specifically expressed in the cortical thymic epithelium is essential for the optimal generation of CD8+ T cells. Although how the thymoproteasome governs the generation of CD8+ T cells is not fully understood, accumulating evidence suggests that the thymoproteasome optimizes CD8+ T cell production through the processing of self-peptides associated wit...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Izumi Ohigashi Yousuke Takahama Source Type: research

Modeling a complex disease: Multiple sclerosis-Update 2020
Adv Immunol. 2021;149:25-34. doi: 10.1016/bs.ai.2021.03.002. Epub 2021 Mar 29.ABSTRACTMultiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with specific requirements-for a systematic overview see our previous issue of this review (Kurschus, Wortge, & Waisman, 2011). However, there is broad consensus about the critical involvement of the immune system in the disease pathogenesis. To better understand how the immune system contributes ...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Tommy Regen Ari Waisman Source Type: research

The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response
Adv Immunol. 2021;149:35-94. doi: 10.1016/bs.ai.2021.03.003. Epub 2021 Apr 23.ABSTRACTGFI1 and GFI1B are small nuclear proteins of 45 and 37kDa, respectively, that have a simple two-domain structure: The first consists of a group of six c-terminal C2H2 zinc finger motifs that are almost identical in sequence and bind to very similar, specific DNA sites. The second is an N-terminal 20 amino acid SNAG domain that can bind to the pocket of the histone demethylase KDM1A (LSD1) near its active site. When bound to DNA, both proteins act as bridging factors that bring LSD1 and associated proteins into the vicinity of methylated s...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Jennifer Fraszczak Tarik M öröy Source Type: research

Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells
Adv Immunol. 2021;149:95-114. doi: 10.1016/bs.ai.2021.03.004. Epub 2021 Apr 27.ABSTRACTAmong the multiple events leading to immunoglobulin (Ig) expression in B cells, stepwise activation of the Ig heavy chain locus (IgH) is of critical importance. Transcription regulation of the complex IgH locus has always been an interesting viewpoint to unravel the multiple and complex events required for IgH expression. First, regulatory germline transcripts (GLT) assist DNA remodeling events such as VDJ recombination, class switch recombination (CSR) and somatic hypermutation (SHM). Second, productive spliced transcripts restrict heav...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Charlotte Bruzeau Jeanne Moreau Sandrine Le Noir Eric Pinaud Source Type: research

Thymoproteasome optimizes positive selection of CD8 < sup > + < /sup > T cells without contribution of negative selection
Adv Immunol. 2021;149:1-23. doi: 10.1016/bs.ai.2021.03.001. Epub 2021 May 1.ABSTRACTFunctionally competent and self-tolerant T cell repertoire is shaped through positive and negative selection in the cortical and medullary microenvironments of the thymus. The thymoproteasome specifically expressed in the cortical thymic epithelium is essential for the optimal generation of CD8+ T cells. Although how the thymoproteasome governs the generation of CD8+ T cells is not fully understood, accumulating evidence suggests that the thymoproteasome optimizes CD8+ T cell production through the processing of self-peptides associated wit...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Izumi Ohigashi Yousuke Takahama Source Type: research

Modeling a complex disease: Multiple sclerosis-Update 2020
Adv Immunol. 2021;149:25-34. doi: 10.1016/bs.ai.2021.03.002. Epub 2021 Mar 29.ABSTRACTMultiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with specific requirements-for a systematic overview see our previous issue of this review (Kurschus, Wortge, & Waisman, 2011). However, there is broad consensus about the critical involvement of the immune system in the disease pathogenesis. To better understand how the immune system contributes ...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Tommy Regen Ari Waisman Source Type: research

The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response
Adv Immunol. 2021;149:35-94. doi: 10.1016/bs.ai.2021.03.003. Epub 2021 Apr 23.ABSTRACTGFI1 and GFI1B are small nuclear proteins of 45 and 37kDa, respectively, that have a simple two-domain structure: The first consists of a group of six c-terminal C2H2 zinc finger motifs that are almost identical in sequence and bind to very similar, specific DNA sites. The second is an N-terminal 20 amino acid SNAG domain that can bind to the pocket of the histone demethylase KDM1A (LSD1) near its active site. When bound to DNA, both proteins act as bridging factors that bring LSD1 and associated proteins into the vicinity of methylated s...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Jennifer Fraszczak Tarik M öröy Source Type: research

Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells
Adv Immunol. 2021;149:95-114. doi: 10.1016/bs.ai.2021.03.004. Epub 2021 Apr 27.ABSTRACTAmong the multiple events leading to immunoglobulin (Ig) expression in B cells, stepwise activation of the Ig heavy chain locus (IgH) is of critical importance. Transcription regulation of the complex IgH locus has always been an interesting viewpoint to unravel the multiple and complex events required for IgH expression. First, regulatory germline transcripts (GLT) assist DNA remodeling events such as VDJ recombination, class switch recombination (CSR) and somatic hypermutation (SHM). Second, productive spliced transcripts restrict heav...
Source: Advances in Immunology - May 17, 2021 Category: Allergy & Immunology Authors: Charlotte Bruzeau Jeanne Moreau Sandrine Le Noir Eric Pinaud Source Type: research