Recent advances in immunopeptidomic-based tumor neoantigen discovery
Adv Immunol. 2023;160:1-36. doi: 10.1016/bs.ai.2023.10.001. Epub 2023 Nov 3.ABSTRACTThe role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells. MS profi...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Wei Meng Robert D Schreiber Cheryl F Lichti Source Type: research
How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens
Adv Immunol. 2023;160:37-57. doi: 10.1016/bs.ai.2023.09.002. Epub 2023 Nov 18.ABSTRACTIn this review we discuss an underexposed mechanism in the adaptive immune system where B cell and T cell immunity collaborate. The main function of B cell immunity is the generation of antibodies which are well known for their high affinity and antigen-specificity. Antibodies can bind antigens in soluble form making so-called immune complexes (ICs) or can opsonize antigen-exposing cells or particles for degradation. This leads to well-known effector mechanisms complement activation, antibody-dependent cytotoxicity and phagocytosis. What ...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Ferry Ossendorp Nataschja I Ho Nadine Van Montfoort Source Type: research
Post-transcriptional regulation of myeloid cell-mediated inflammatory responses
Adv Immunol. 2023;160:59-82. doi: 10.1016/bs.ai.2023.09.001. Epub 2023 Sep 27.ABSTRACTMyeloid cells, particularly macrophages, act as the frontline responders to infectious agents and initiate inflammation. While the molecular mechanisms driving inflammatory responses have primarily focused on pattern recognition by myeloid cells and subsequent transcriptional events, it is crucial to note that post-transcriptional regulation plays a pivotal role in this process. In addition to the transcriptional regulation of innate immune responses, additional layers of intricate network of post-transcriptional mechanisms critically det...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Xingxian Liu Weidong Han Xiaoyu Hu Source Type: research
Immunometabolism of dendritic cells in health and disease
Adv Immunol. 2023;160:83-116. doi: 10.1016/bs.ai.2023.10.002. Epub 2023 Oct 25.ABSTRACTDendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific microenvironments and immunological conditions. DCs undergo metabolic adaptation to exert immunogenic or tolerogenic effects in different contexts. Also, beyond their intracellular metabolic and signaling roles, metabolites and nutrients mediate the intercellular crosstalk between DCs and other cell t...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Chuansheng Guo Hongbo Chi Source Type: research
Recent advances in immunopeptidomic-based tumor neoantigen discovery
Adv Immunol. 2023;160:1-36. doi: 10.1016/bs.ai.2023.10.001. Epub 2023 Nov 3.ABSTRACTThe role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells. MS profi...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Wei Meng Robert D Schreiber Cheryl F Lichti Source Type: research
How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens
Adv Immunol. 2023;160:37-57. doi: 10.1016/bs.ai.2023.09.002. Epub 2023 Nov 18.ABSTRACTIn this review we discuss an underexposed mechanism in the adaptive immune system where B cell and T cell immunity collaborate. The main function of B cell immunity is the generation of antibodies which are well known for their high affinity and antigen-specificity. Antibodies can bind antigens in soluble form making so-called immune complexes (ICs) or can opsonize antigen-exposing cells or particles for degradation. This leads to well-known effector mechanisms complement activation, antibody-dependent cytotoxicity and phagocytosis. What ...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Ferry Ossendorp Nataschja I Ho Nadine Van Montfoort Source Type: research
Post-transcriptional regulation of myeloid cell-mediated inflammatory responses
Adv Immunol. 2023;160:59-82. doi: 10.1016/bs.ai.2023.09.001. Epub 2023 Sep 27.ABSTRACTMyeloid cells, particularly macrophages, act as the frontline responders to infectious agents and initiate inflammation. While the molecular mechanisms driving inflammatory responses have primarily focused on pattern recognition by myeloid cells and subsequent transcriptional events, it is crucial to note that post-transcriptional regulation plays a pivotal role in this process. In addition to the transcriptional regulation of innate immune responses, additional layers of intricate network of post-transcriptional mechanisms critically det...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Xingxian Liu Weidong Han Xiaoyu Hu Source Type: research
Immunometabolism of dendritic cells in health and disease
Adv Immunol. 2023;160:83-116. doi: 10.1016/bs.ai.2023.10.002. Epub 2023 Oct 25.ABSTRACTDendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific microenvironments and immunological conditions. DCs undergo metabolic adaptation to exert immunogenic or tolerogenic effects in different contexts. Also, beyond their intracellular metabolic and signaling roles, metabolites and nutrients mediate the intercellular crosstalk between DCs and other cell t...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Chuansheng Guo Hongbo Chi Source Type: research
Recent advances in immunopeptidomic-based tumor neoantigen discovery
Adv Immunol. 2023;160:1-36. doi: 10.1016/bs.ai.2023.10.001. Epub 2023 Nov 3.ABSTRACTThe role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells. MS profi...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Wei Meng Robert D Schreiber Cheryl F Lichti Source Type: research
How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens
Adv Immunol. 2023;160:37-57. doi: 10.1016/bs.ai.2023.09.002. Epub 2023 Nov 18.ABSTRACTIn this review we discuss an underexposed mechanism in the adaptive immune system where B cell and T cell immunity collaborate. The main function of B cell immunity is the generation of antibodies which are well known for their high affinity and antigen-specificity. Antibodies can bind antigens in soluble form making so-called immune complexes (ICs) or can opsonize antigen-exposing cells or particles for degradation. This leads to well-known effector mechanisms complement activation, antibody-dependent cytotoxicity and phagocytosis. What ...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Ferry Ossendorp Nataschja I Ho Nadine Van Montfoort Source Type: research
Post-transcriptional regulation of myeloid cell-mediated inflammatory responses
Adv Immunol. 2023;160:59-82. doi: 10.1016/bs.ai.2023.09.001. Epub 2023 Sep 27.ABSTRACTMyeloid cells, particularly macrophages, act as the frontline responders to infectious agents and initiate inflammation. While the molecular mechanisms driving inflammatory responses have primarily focused on pattern recognition by myeloid cells and subsequent transcriptional events, it is crucial to note that post-transcriptional regulation plays a pivotal role in this process. In addition to the transcriptional regulation of innate immune responses, additional layers of intricate network of post-transcriptional mechanisms critically det...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Xingxian Liu Weidong Han Xiaoyu Hu Source Type: research
Immunometabolism of dendritic cells in health and disease
Adv Immunol. 2023;160:83-116. doi: 10.1016/bs.ai.2023.10.002. Epub 2023 Oct 25.ABSTRACTDendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific microenvironments and immunological conditions. DCs undergo metabolic adaptation to exert immunogenic or tolerogenic effects in different contexts. Also, beyond their intracellular metabolic and signaling roles, metabolites and nutrients mediate the intercellular crosstalk between DCs and other cell t...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Chuansheng Guo Hongbo Chi Source Type: research
Recent advances in immunopeptidomic-based tumor neoantigen discovery
Adv Immunol. 2023;160:1-36. doi: 10.1016/bs.ai.2023.10.001. Epub 2023 Nov 3.ABSTRACTThe role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells. MS profi...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Wei Meng Robert D Schreiber Cheryl F Lichti Source Type: research
How B cells drive T-cell responses: A key role for cross-presentation of antibody-targeted antigens
Adv Immunol. 2023;160:37-57. doi: 10.1016/bs.ai.2023.09.002. Epub 2023 Nov 18.ABSTRACTIn this review we discuss an underexposed mechanism in the adaptive immune system where B cell and T cell immunity collaborate. The main function of B cell immunity is the generation of antibodies which are well known for their high affinity and antigen-specificity. Antibodies can bind antigens in soluble form making so-called immune complexes (ICs) or can opsonize antigen-exposing cells or particles for degradation. This leads to well-known effector mechanisms complement activation, antibody-dependent cytotoxicity and phagocytosis. What ...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Ferry Ossendorp Nataschja I Ho Nadine Van Montfoort Source Type: research
Post-transcriptional regulation of myeloid cell-mediated inflammatory responses
Adv Immunol. 2023;160:59-82. doi: 10.1016/bs.ai.2023.09.001. Epub 2023 Sep 27.ABSTRACTMyeloid cells, particularly macrophages, act as the frontline responders to infectious agents and initiate inflammation. While the molecular mechanisms driving inflammatory responses have primarily focused on pattern recognition by myeloid cells and subsequent transcriptional events, it is crucial to note that post-transcriptional regulation plays a pivotal role in this process. In addition to the transcriptional regulation of innate immune responses, additional layers of intricate network of post-transcriptional mechanisms critically det...
Source: Advances in Immunology - December 2, 2023 Category: Allergy & Immunology Authors: Xingxian Liu Weidong Han Xiaoyu Hu Source Type: research
