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Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study
CONCLUSION: Concentrations of cTnI measured with a very high sensitivity assay are predictive of carotid atherosclerotic burden, a phenomenon likely attributable to common risk factors of subclinical myocardial injury, coronary and carotid atherosclerosis.PMID:33861986 | DOI:10.1016/j.clinbiochem.2021.04.005
Source: Clinical Biochemistry - April 16, 2021 Category: Biochemistry Authors: Magnus Nakrem Lyngbakken Thea Vigen H åkon Ihle-Hansen Jon Brynildsen Trygve Berge Ole Morten R ønning Arnljot Tveit Helge R øsjø Torbj ørn Omland Source Type: research

Serum 25-hydroxyvitamin D, cardiovascular risk markers, and incident cardiovascular disease in a high risk community population
CONCLUSIONS: Vitamin D status likely offers no additional information on CVD risk over conventional laboratory-measured risk markers.PMID:33831385 | DOI:10.1016/j.clinbiochem.2021.04.001
Source: Clinical Biochemistry - April 8, 2021 Category: Biochemistry Authors: Jaeun Yang Yuan Dong Christopher T Naugler Lawrence de Koning Source Type: research

Association of LDLc to HDLc ratio with carotid plaques in a community-based population with a high stroke risk: a cross-sectional study in China.
CONCLUSION: Higher LDLc/HDLc was significantly associated with the presence of carotid plaques in the Chinese population with a high risk of stroke. PMID: 33242435 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - November 23, 2020 Category: Biochemistry Authors: Geng Y, Liu Y, Chen Y, Zhang Z, Wang L, Li X, Xia B, Song B, Zhang H Tags: Clin Biochem Source Type: research

Interleukin-18 promoter -137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients.
CONCLUSION: These results suggest that Brazilian T2DM patients with the CC genotype seem to show a predisposition to CVD, as well as an elevation in markers of renal function. PMID: 32209332 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - March 20, 2020 Category: Biochemistry Authors: Cavalcante JEA, de Sousa ELH, de Oliveira Rodrigues R, de Almeida Viana G, Duarte Gadelha D, de Carvalho MMD, Sousa DL, Silva AJX, Filho RRBX, Fernandes VO, Júnior RMM, de Sousa Alves R, Meneses GC, Sampaio TL, Queiroz MGR Tags: Clin Biochem Source Type: research

Rare P376L variant in the SR-BI gene associates with HDL dysfunction and risk of cardiovascular disease.
CONCLUSION: We have found that carriers of the P376L variant possessed higher HDLox and were at increased risk of CVD in a representative population-based cohort, as compared to non-carriers. PMID: 31251897 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - June 24, 2019 Category: Biochemistry Authors: Samadi S, Farjami Z, Hosseini ZS, Ferns GA, Mohammadpour AH, Tayefi M, Fal-Soleiman H, Moohebati M, Ghayour-Mobarhan M, Esmaily H, Avan A Tags: Clin Biochem Source Type: research

Diagnostic accuracy of biomarker D-dimer in patients after stroke suspected from venous thromboembolism: A diagnostic meta-analysis.
Abstract D-dimer is a promising biomarker for identification of venous thromboembolism (VTE) in patients with stroke. The purpose of our study is to evaluate the diagnostic value of D-dimer as a promising biomarker for VTE in patients after stroke. We performed an exhaustive search of leading databases including Pubmed, Embase, the Cochrane library, China National Knowledge Infrastructure (CNKI), and China Biology Medicine disc (CBM) from inception to Oct 13, 2017. We included studies written in English and Chinese. We included studies that appraised the diagnostic value of D-dimer with reference standard for VTE ...
Source: Clinical Biochemistry - September 24, 2018 Category: Biochemistry Authors: Zhang D, Li F, Du X, Zhang X, Zhang Z, Zhao W, Du G Tags: Clin Biochem Source Type: research

Association of vascular indices with novel circulating biomarkers as prognostic factors for cardiovascular complications in patients with type 2 diabetes mellitus.
CONCLUSION: In T2DM patients without established cardiovascular disease, novel indices of vascular inflammation (NGAL and YKL-40) were associated with subclinical atherosclerosis (arterial stiffness) but also with adverse clinical prognosis. Arterial stiffness and endothelial dysfunction were also independently related to adverse prognosis. PMID: 29288632 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - December 27, 2017 Category: Biochemistry Authors: Naka KK, Papathanassiou K, Bechlioulis A, Pappas K, Tigas S, Makriyiannis D, Antoniou S, Kazakos N, Margeli A, Papassotiriou I, Tsatsoulis A, Michalis LK Tags: Clin Biochem Source Type: research

Paraoxonase 1 (PON1) and stroke; the dilemma of the genetic variation.
Abstract Ischaemic stroke, which is mostly caused by atherosclerosis, is one of the most widely causes of mortality and morbidity. One of the most important enzymatic activities of paraoxonase-1 (PON1) in association with high-density lipoprotein (HDL) is the prevention of low-density lipoprotein (LDL) oxidation, which gives it an anti-atherogenic activity. PON1 expression and activity is influenced by various factors; the most important of which is genetic polymorphism, mainly single nucleotide polymorphisms (SNPs). The results of various studies in different populations indicate that some SNPs of the PON1 gene a...
Source: Clinical Biochemistry - August 2, 2017 Category: Biochemistry Authors: Tajbakhsh A, Rezaee M, Rivandi M, Forouzanfar F, Afzaljavan F, Pasdar A Tags: Clin Biochem Source Type: research

Relationship between serum anti-heat shock protein 27 antibody levels and obesity.
CONCLUSION: We have found that serum anti-HSP27 antibody titers are related to several cardiovascular risk factors, necessitating further studies on the value of this emerging marker for risk stratification. PMID: 28237841 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - February 21, 2017 Category: Biochemistry Authors: Kargari M, Tavassoli S, Avan A, Ebrahimi M, Azarpazhooh MR, Asoodeh R, Nematy M, Hassanian SM, Rahmani F, Mohammadzade E, Esmaeili H, Moohebati M, Ferns GA, Ghayour-Mobarhan M, Parizadeh SM Tags: Clin Biochem Source Type: research

Utility of high density lipoprotein particle concentration in predicting future major adverse cardiovascular events among patients undergoing angiography.
CONCLUSION: In this study of patients undergoing angiography, HDL-P was a strong, independent predictor of future MACE, with the smaller HDL-P accounting for this association. PMID: 27616009 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - September 7, 2016 Category: Biochemistry Authors: May HT, Anderson JL, Winegar DA, Rollo J, Connelly MA, Otvos JD, Muhlestein JB Tags: Clin Biochem Source Type: research

B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain.
CONCLUSIONS: In patients with chest pain, BNPsp is predictive of MI but is not a useful adjunct to troponin. However, the ability of BNPsp, in conjunction with NT-proBNP and key analytes, to diagnose UAP and other ischemic syndromes merits further investigation. PMID: 26968107 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - March 9, 2016 Category: Biochemistry Authors: Pemberton CJ, Frampton CM, Aldous S, Bailey M, Young J, Troughton R, Than M, Richards M Tags: Clin Biochem Source Type: research

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