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Specialty: Biochemistry
Source: Biochimica et Biophysica Acta

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Total 36 results found since Jan 2013.

Stroke injury, cognitive impairment and vascular dementia.
This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID: 26806700 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 21, 2016 Category: Biochemistry Authors: Kalaria RN, Akinyemi R, Ihara M Tags: Biochim Biophys Acta Source Type: research

Heat Shock Protein A12A Encodes a Novel Prosurvival Pathway during Ischaemic Stroke.
This study investigated the effects of HSPA12A on ischaemic stroke in mice. Ischaemic stroke was induced by left middle cerebral artery occlusion for 1 h followed by blood reperfusion. We observed that HSPA12A was highly expressed in brain neurons, and neuronal HSPA12A expression was downregulated by ischaemic stroke and stroke-associated risk factors (aging, obesity and hyperglycaemia). To investigate the functional requirement of HSPA12A in protecting ischaemic brain injury, HSPA12A knockout mice (Hspa12a-/-) were generated. Hspa12a-/- mice exhibited an enlarged infarct volume and aggravated neurological deficits compare...
Source: Biochimica et Biophysica Acta - March 9, 2018 Category: Biochemistry Authors: Mao Y, Kong Q, Li R, Zhang X, Gui Y, Li Y, Li C, Zhao Y, Liu L, Ding Z Tags: Biochim Biophys Acta Source Type: research

Neuroinflammatory biomarkers: From stroke diagnosis and prognosis to therapy.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26524637 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - October 30, 2015 Category: Biochemistry Authors: Simats A, García-Berrocoso T, Montaner J Tags: Biochim Biophys Acta Source Type: research

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.
lanas A, Roquer J, Valverde MA, Muñoz FJ Abstract Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide synthesis to recover blood flow but also induces a free radical burst. Nitric oxide and superoxide anion react to generate peroxynitrite that nitrates tyrosines. We found that fibrinogen nitrotyrosination was detected in plasma after the initiation of ischemic stroke in human patients. Electron microscopy and protein intrinsic fluorescence showed that...
Source: Biochimica et Biophysica Acta - December 12, 2014 Category: Biochemistry Authors: Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Tajes M, Valls-Comamala V, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Gil-Gómez G, López-Vílchez I, Galán AM, Alameda F, Escolar G, Opazo C, Tags: Biochim Biophys Acta Source Type: research

Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization
Biochim Biophys Acta Mol Basis Dis. 2023 Jun 5:166771. doi: 10.1016/j.bbadis.2023.166771. Online ahead of print.ABSTRACTTo date, various agents and molecules have been developed to treat post-stroke neuroinflammation; however, none of them are clinically successful. Post-stroke neuroinflammation is primarily attributed to microglial polarization as the generation of inflammasome complexes shifts microglia to their M1 phenotype and regulate the downstream cascade. Inosine, an adenosine derivative reported to maintain cellular energy homeostasis in stressed condition. Although, the exact mechanism is still unexplored, variou...
Source: Biochimica et Biophysica Acta - June 7, 2023 Category: Biochemistry Authors: Aishika Datta Pramod Suthar Deepaneeta Sarmah Poonam Jadhav Jinagna Shah Mounika Katamneni Nikhil Bhosale Vishal Gupta Mariya Bohra Falguni Baidya Nikita Rana Bijoyani Ghosh Harpreet Kaur Anupom Borah Rajeshwari Rathod Pinaki Sengupta Pallab Bhattacharya Source Type: research

Protective features of peripheral monocytes/macrophages in stroke.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26584587 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 12, 2015 Category: Biochemistry Authors: Gliem M, Schwaninger M, Jander S Tags: Biochim Biophys Acta Source Type: research

Imaging of Neuroinflammation in Alzheimer's Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26643549 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 28, 2015 Category: Biochemistry Authors: Janssen B, Vugts DJ, Funke U, Molenaar GT, Kruijer PS, van Berckel BN, Lammertsma AA, Windhorst AD Tags: Biochim Biophys Acta Source Type: research

Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 May 20:159182. doi: 10.1016/j.bbalip.2022.159182. Online ahead of print.ABSTRACTHDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 and apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In add...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: F M Sacks J D Furtado M K Jensen Source Type: research

Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression.
CONCLUSIONS: Human AAT protects neuronal and glial cells against OGD through interaction with cytokines. GENERAL SIGNIFICANCE: Human AAT could be a good therapeutic neuroprotective candidate to treat ischemic stroke. PMID: 29857082 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - May 29, 2018 Category: Biochemistry Authors: Cabezas-Llobet N, Camprubí S, García B, Alberch J, Xifró X Tags: Biochim Biophys Acta Source Type: research

Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion.
This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo Escríba-Ruíz. PMID: 28315303 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 13, 2017 Category: Biochemistry Authors: Ugidos IF, Santos-Galdiano M, Pérez-Rodríguez D, Anuncibay-Soto B, Font-Belmonte E, López DJ, Ibarguren M, Busquets X, Fernández López A Tags: Biochim Biophys Acta Source Type: research

Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26499397 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - October 21, 2015 Category: Biochemistry Authors: Simon MJ, Iliff JJ Tags: Biochim Biophys Acta Source Type: research

Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia.
In this study, we have established that AT2R stimulation by C21 compound, a specific AT2R agonist, caused a VEGF upregulation. Using mouse primary cortical neurons exposed to oxygen-glucose deprivation (OGD), we established that this effect was mediated by a mechanism dependent of mTORC1 signaling since mTOR inhibition abolished the C21-induced VEGF upregulation. Also, we have temporally characterized the changes on VEGF levels after ischemia induction in rats using two different approaches: transient and permanent middle cerebral artery occlusion (tMCAO and pMCAO). VEGF levels were permanently augmented after reperfusion ...
Source: Biochimica et Biophysica Acta - March 31, 2016 Category: Biochemistry Authors: Mateos L, Perez-Alvarez MJ, Wandosell F Tags: Biochim Biophys Acta Source Type: research