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Source: Biochemical and Biophysical Research communications
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Total 77 results found since Jan 2013.
Protective effects of Japanese sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion
This study evaluates the effects of sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion. Rats were divided into four groups, including 1) control: without bilateral common carotid artery occlusion (BCCAO) and sake supplement, 2) Ischemia group: rats induced with BCCAO and lack of therapeutic supplement, and 3 and 4) Ischemia + sake groups: rats induced with BCCAO and treated with 25 and 50 mg/kg sake yeast, respectively. Depressive-like behaviors antioxidant enzymes activities were assessed. The induction of stroke increased oxidant st...
Source: Biochemical and Biophysical Research communications - July 7, 2023 Category: Biochemistry Authors: Maryam Vaghari Akbar Hajizadeh Moghaddam Mojtaba Ranjbar Nasrollah Moradikor Source Type: research
Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Biochemical and Biophysical Research communications - June 10, 2023 Category: Biochemistry Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research
TGF- β1 ameliorates BBB injury and improves long-term outcomes in mice after ICH
Biochem Biophys Res Commun. 2023 Mar 6;654:136-144. doi: 10.1016/j.bbrc.2023.03.007. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating subtype of stroke characterized by high mortality and morbidity rates with no effective treatment. TGF-β/ALK-5 signaling is reported to participated in the regulation of blood-brain barrier (BBB) integrity in the inflammation pain model, the effects of transforming growth factor (TGF)-β1 and the potential mechanisms on BBB after ICH have not been fully elucidated. Herein, we have demonstrated that peripheral administration of TGF-β1 reduces brain edema and ame...
Source: Biochemical and Biophysical Research communications - March 17, 2023 Category: Biochemistry Authors: Huimei Wen Jiaying Tan Mi Tian Yao Wang Yanqin Gao Ye Gong Source Type: research
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1
CONCLUSION: Collectively, exosomal miR-145-derived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1. These studies may serve as a potential approach for treating of cerebral I/R injury.PMID:36206599 | DOI:10.1016/j.bbrc.2022.09.089
Source: Biochemical and Biophysical Research communications - October 7, 2022 Category: Biochemistry Authors: Hai Zhou Jing Zhou Hongwei Teng Hua Yang Jinsong Qiu Xiangdong Li Source Type: research
Therapeutic effect of fastigial nucleus stimulation is mediated by the microRNA-182 & amp; microRNA-382/BDNF signaling pathways in the treatment of post-stroke depression
In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD.PMID:36030655 | DOI:10.1016/j.bbrc.2022.05.038
Source: Biochemical and Biophysical Research communications - August 28, 2022 Category: Biochemistry Authors: Zhuang Zhang Dong-Jian Xia An-Ding Xu Source Type: research
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research
MnCO < sub > 3 < /sub > @BSA-ICG nanoparticles as a magnetic resonance/photoacoustic dual-modal contrast agent for functional imaging of acute ischemic stroke
Biochem Biophys Res Commun. 2022 May 5;614:125-131. doi: 10.1016/j.bbrc.2022.04.143. Online ahead of print.ABSTRACTTimely and accurate diagnosis of acute ischemic stroke (AIS) and simultaneous functional imaging of cerebral oxygen saturation (sO2) are essential to improve the survival rate of stroke patients but remains challenging. Herein, we developed a pH-responsive manganese (Mn)-based nanoplatform as a magnetic resonance/photoacoustic (MR/PA) dual-modal contrast agent for AIS diagnosis. The Mn-based nanoplatform was prepared via a simple and green biomimetic method using bovine serum albumin (BSA) as a scaffold for fa...
Source: Biochemical and Biophysical Research communications - May 17, 2022 Category: Biochemistry Authors: Guangrong Song Baorui Zhang Linyan Song Wenzhe Li Chuxuan Liu Leshan Chen Aihua Liu Source Type: research
Long noncoding RNA H19 mediates neural stem/progenitor cells proliferation, differentiation and apoptosis through the p53 signaling pathway after ischemic stroke
In this study, our results showed that knockdown of H19 significantly inhibited NSPCs proliferation. Additionally, the apoptosis of NSPCs after ODG/R injury was notably promoted by H19 knockdown. Cell cycle arrest was induced in NSPCs at G0/G1 phase after OGD/R, while knockdown of H19 decreased the percentage of cells at G2/S phase. The results of immunofluorescence analysis revealed that H19 knockdown reduced the staining intensity of Ki-67 and DCX. Furthermore, H19 knockdown enhanced the expression of p53, Bax and Cleaved Caspase-3, while Bcl-2 expression was decreased. Silencing of H19 suppressed the NSPCs proliferation...
Source: Biochemical and Biophysical Research communications - February 5, 2022 Category: Biochemistry Authors: Li Gan Shengtao Liao Yanqiu Tong Weihan Li Wenli Peng Shixiong Deng Source Type: research
