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Source: The American Journal of Medicine

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Total 259 results found since Jan 2013.

TIA for the Internist
A few times a year, an internal medicine colleague asks, “Can you tell me TIA (transient ischemic attack) in a nutshell?” With the new stroke and TIA guidelines coming out this May,1 the case below is all too familiar.
Source: The American Journal of Medicine - July 2, 2014 Category: Journals (General) Authors: Shuhan Zhu, Michael D. Perloff Tags: Commentary Source Type: research

Stroke and Bleeding Risk Co-distribution in Real-world Patients with Atrial Fibrillation: The Euro Heart Survey
The choice to recommend antithrombotic therapy to patients with atrial fibrillation should rely on cardioembolic and bleeding risk stratification. Sharing some risk factors, schemes to predict thrombotic and bleeding risk are expected not to be independent, yet the degree of their association has never been clearly quantified.
Source: The American Journal of Medicine - May 13, 2014 Category: Journals (General) Authors: Maura Marcucci, Gregory Y.H. Lip, Robby Nieuwlaat, Ron Pisters, Harry J.G.M. Crijns, Alfonso Iorio Tags: Clinical research study Source Type: research

The Case of the Furtive Flutter: Atypical Atrial Flutter
A patient's arrhythmia was identified only after an electrocardiogram (ECG) lead was attached directly to an atrial epicardial lead. The 87-year-old man had a history of paroxysmal atrial fibrillation, coronary artery disease, and severe mitral and tricuspid regurgitation; he was admitted for corrective cardiac surgery. His history included a cardioembolic stroke 10 months prior to admission, hypertension, and hyperlipidemia. He underwent coronary artery bypass grafting (CABG) to the right coronary artery, bioprosthetic mitral valve replacement, tricuspid annulus repair, and a maze cryoablation or cryomaze procedure.
Source: The American Journal of Medicine - July 31, 2014 Category: Journals (General) Authors: Jeffrey Paulsen, Gagan Singh, Uma Srivatsa, Ezra A. Amsterdam Tags: ECG image of the month Source Type: research

SAMe-TTR Score, Time in Therapeutic Range, and Outcomes in Anticoagulated Patients with Atrial Fibrillation
Oral anticoagulation is highly effective in preventing stroke and mortality in nonvalvular atrial fibrillation patients. However, the efficacy and safety of vitamin K antagonists (the main oral anticoagulation drug used) strongly depends upon the quantity of anticoagulation control, as reflected by the average percentage of the time in therapeutic range of international normalized ratio 2.0-3.0. An easy, simple prediction of which atrial fibrillation patients are likely to do well on vitamin K antagonists (with good average time in therapeutic range) could guide decision-making between using vitamin K antagonists (eg, warf...
Source: The American Journal of Medicine - May 22, 2014 Category: Journals (General) Authors: Pilar Gallego, Vanessa Roldán, Francisco Marin, José Gálvez, Mariano Valdés, Vicente Vicente, Gregory Y.H. Lip Tags: Clinical research study Source Type: research

Antiphospholipid syndrome: an important differential diagnosis for culture-negative endocarditis
Sometimes the initial diagnosis proves secondary to an illness that is diagnosed later. This was the case when a 37-year-old woman presented to the hospital with sudden-onset persistent left-sided weakness. While she reported pain in the right maxilla, lethargy, and malaise in the month prior to presentation, she denied headache, sensory change, visual disturbances, fever, chills or weight loss. Hypertension was her only cardiovascular risk factor, but she took no regular medications. She had no history of stroke, ischemic heart disease, deep vein thrombosis, pulmonary embolism, or miscarriage, and she had no family histor...
Source: The American Journal of Medicine - November 26, 2014 Category: Journals (General) Authors: Louis W. Wang, Baptiste Noël, Elodie Descloux, David W. Baron Source Type: research

Predictors of intraoperative hypotension and bradycardia
Perioperative hypotension and bradycardia in the surgical patient is associated with adverse outcomes including stroke. We developed and evaluated a new preoperative risk model in predicting intraoperative hypotension or bradycardia in patients undergoing elective non-cardiac surgery.
Source: The American Journal of Medicine - December 22, 2014 Category: Journals (General) Authors: Christopher Cheung, Alan Martyn, Norman Campbell, Shaun Frost, Kenneth Gilbert, Franklin Michota, Douglas Seal, William Ghali, Nadia Khan Source Type: research

History of Thyroid Disorders in Relation to Clinical Outcomes in Atrial Fibrillation
Atrial fibrillation is the most common cardiac complication of hyperthyroidism. The association between history of hyperthyroidism and stroke remains unclear. We sought to determine whether history of thyroid dysfunction is a thromboembolic risk factor in patients with atrial fibrillation.
Source: The American Journal of Medicine - July 21, 2014 Category: Journals (General) Authors: Helene Bruere, Laurent Fauchier, Anne Bernard Brunet, Bertrand Pierre, Edouard Simeon, Dominique Babuty, Nicolas Clementy Tags: Clinical research study Source Type: research

Totally one-sided: painless unilateral proptosis
An 88-year-old woman’s startling ophthalmologic symptoms were wrongly attributed to infection during an outpatient examination. When treatment offered no improvement, she presented to Johns Hopkins Hospital, where she reported progressive left eye swelling of 2 weeks’ duration. Seven years earlier, she had undergone mastectomy, chemotherapy, and radiation for breast cancer. Her medical history was also significant for a prior stroke, hypertension, and dementia.
Source: The American Journal of Medicine - January 5, 2015 Category: Journals (General) Authors: Bharati Kochar, Shannon J.C. Shan, Gobind Anand, S. James Zinreich, Allan C. Gelber Source Type: research

Misconceptions and Facts about Atrial Fibrillation
Atrial fibrillation is an increasingly common arrhythmia associated with substantial but largely preventable risk of ischemic stroke. There has been an exponential increase in research related to atrial fibrillation in recent years resulting in some major advances in the therapeutic management. Novel oral anticoagulant agents have become available and require thorough assessment of risk benefit ratio. While the knowledge is rapidly accumulating the basic principles of atrial fibrillation management remain proper recognition, risk stratification, and appropriate prevention of thromboembolic complications.
Source: The American Journal of Medicine - March 28, 2015 Category: Journals (General) Authors: Edgar Argulian, David Conen, Franz H. Messerli Tags: Review Source Type: research

The Diabetes Shared Care Program and Risks of Cardiovascular Events in Type 2 Diabetes
The Diabetes Shared Care Program (DSCP) is an integrated diabetes care model designed to increase the quality of diabetes care in Taiwan. The efficacy of this program is unknown. Therefore, we evaluated whether participating patients had reduced risks of cardiovascular events, including coronary heart disease, stroke, and all-cause mortality.
Source: The American Journal of Medicine - April 20, 2015 Category: Journals (General) Authors: Edy Kornelius, Jeng-Yuan Chiou, Yi-Sun Yang, Ying-Li Lu, Chiung-Huei Peng, Chien-Ning Huang Tags: Clinical Research Study Source Type: research

Summer Syncope Syndrome Redux
The objective of the present study was to investigate whether the results of our prior study involving continued use of antihypertensive drugs at the same dosage in the summer as in the winter months for patients living in the Sonoran desert resulted in an increase in syncopal episodes during the hot summer months.
Source: The American Journal of Medicine - June 4, 2015 Category: Journals (General) Authors: Jennifer Juxiang Huang, Chirag Desai, Nirmal Singh, Natasha Sharda, Irbaz Riaz, Joseph Alpert Tags: Brief Observation Source Type: research

Neither Abusiveness with Patients nor Naivety with Drugs
Kelly et al1 must be commended for condemning abusive language for individuals with addiction (eg, substance “abusers” or “addicts”) and recommending the use of “people with a substance use disorder.” Indeed, reducing stigma is vital for building the therapeutic alliance with these patients with low self-esteem. Sadly, this is not yet usual: Elkind,2 when discussing the risk of recurrent ischemic stroke, called smoking a “volitional behavior.” However, the condemnation of public health messages such as “war on drugs” or “You use, you lose” deserves comments.
Source: The American Journal of Medicine - June 17, 2015 Category: Journals (General) Authors: Alain Braillon Tags: AJM online Source Type: research

Antithrombotic treatment patterns in 10 871 patients with newly diagnosed non-valvular atrial fibrillation: the GLORIA-AF Registry Program, Phase II
The Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) was designed to provide prospectively collected information on patients with newly diagnosed non-valvular atrial fibrillation at risk of stroke, with the aim of addressing treatment patterns and questions of effectiveness and safety.
Source: The American Journal of Medicine - July 31, 2015 Category: Journals (General) Authors: M.V. Huisman, K.J. Rothman, M. Paquette, C. Teutsch, H.C. Diener, S.J. Dubner, J.L. Halperin, Changsheng Marín, C.S. Ma, K. Zint, A. Elsaesser, D.B. Bartels, G.Y.H. Lip, GLORIA-AF Investigators Tags: Clinical Research Study Source Type: research

Improving medication adherence in patients with hypertension: a randomized trial
and Purpose: In patients with hypertension, medication adherence is often suboptimal, thereby increasing the risk of ischemic heart disease and stroke. In a randomized trial, we investigated the effectiveness of a multifaceted pharmacist intervention in a hospital setting to improve medication adherence in hypertensive patients. Motivational interviewing was a key element of the intervention.
Source: The American Journal of Medicine - August 21, 2015 Category: Journals (General) Authors: Ulla Hedegaard, Lene Juel Kjeldsen, Anton Pottegård, Jan Erik Henriksen, Jess Lambrectsen, Jørgen Hangaard, Jesper Hallas Tags: Clinical Research Study Source Type: research

Antithrombotic Treatment Patterns in 10,871 Patients with Newly Diagnosed Nonvalvular Atrial Fibrillation: The GLORIA-AF Registry, Phase II
The Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) was designed to provide prospectively collected information on patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke, with the aim of addressing treatment patterns and questions of effectiveness and safety.
Source: The American Journal of Medicine - July 31, 2015 Category: Journals (General) Authors: Menno V. Huisman, Kenneth J. Rothman, Miney Paquette, Christine Teutsch, Hans Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Changsheng Ma, Kristina Zint, Amelie Elsaesser, Dorothee B. Bartels, Gregory Y.H. Lip, GLORIA-AF Investigators Tags: Clinical research study Source Type: research