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Impact of Female Gender on Bleeding Complications After Transradial Coronary Intervention (from the Korean Transradial Coronary Intervention Registry)
This study aimed to investigate the impact of gender on clinical outcomes and bleeding complications after transradial coronary intervention (TRI). The Korean TRI registry is a retrospective multicenter registry with 4,890 patients who underwent percutaneous coronary intervention in 2009 at 12 centers. To compare clinical outcomes and bleeding complications between the male and female groups, we performed a propensity score matching in patients who received TRI. A total of 1,194 patients (597 in each group) were studied. The primary outcome was 1-year major adverse cardiac events, including all-cause mortality, myocardial ...
Source: The American Journal of Cardiology - April 3, 2014 Category: Cardiology Authors: Jeoung-Sook Shin, Seung-Jea Tahk, Hyoung-Mo Yang, Myeong-Ho Yoon, So-Yeon Choi, Byoung-Joo Choi, Hong-Seok Lim, You-Hong Lee, Kyoung-Woo Seo, Se-Jun Park, Yong-Woo Choi, Junghan Yoon, Young Jin Youn, Byung Ryeol Cho, Kwang Soo Cha, Kyoo Rok Han, Min Su Hy Tags: Coronary Artery Disease Source Type: research

Risk of Stroke in Patients With High On-Clopidogrel Platelet Reactivity to Adenosine Diphosphate After Percutaneous Coronary Intervention
In conclusion, in patients with coronary artery disease undergoing PCI, the presence of HPR to adenosine diphosphate is a risk factor for stroke.
Source: The American Journal of Cardiology - March 17, 2014 Category: Cardiology Authors: Nevio Taglieri, Maria Letizia Bacchi Reggiani, Tullio Palmerini, Gabriele Ghetti, Francesco Saia, Pamela Gallo, Carolina Moretti, Gianni Dall'Ara, Cinzia Marrozzini, Antonio Marzocchi, Claudio Rapezzi Tags: Coronary Artery Disease Source Type: research

Impact of Multiple Complex Plaques on Short- and Long-Term Clinical Outcomes in Patients Presenting With ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction HORIZONS-AMI Trial)
It is not known whether the extent and severity of nonculprit coronary lesions correlate with outcomes in patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention (PCI). We sought to quantify complex plaques in patients with STEMI referred for primary PCI and to determine their effect on short- and long-term clinical outcomes by examining the core laboratory database for plaque analysis from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction study. Baseline demographic, angiographic, and procedural details were compared b...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Ellen C. Keeley, Roxana Mehran, Sorin J. Brener, Bernhard Witzenbichler, Giulio Guagliumi, Dariusz Dudek, Ran Kornowski, Ovidiu Dressler, Martin Fahy, Ke Xu, Cindy L. Grines, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research

Unanswered Questions in Patients With Concurrent Atrial Fibrillation and Acute Coronary Syndrome
In conclusion, until the results of additional ongoing or planned randomized trials are known, clinicians must continue to rely on expert opinion and their own clinical judgment when treating these patients.
Source: The American Journal of Cardiology - December 16, 2013 Category: Cardiology Authors: Daniel S. Ice, Timothy A. Shapiro, Eric M. Gnall, Peter R. Kowey Tags: Review Source Type: research

Results of Primary Percutaneous Coronary Intervention in Patients ≥75 Years Treated by the Transradial Approach
In conclusion, TRA-PPCI was feasible in the vast majority of elderly patients with STEMI. In-hospital mortality, 1-year mortality, and 1-year MACE were lower than reported for transfemoral access, suggesting a benefit of the TRA in these patients.
Source: The American Journal of Cardiology - November 11, 2013 Category: Cardiology Authors: Oriol Rodriguez-Leor, Eduard Fernandez-Nofrerias, Xavier Carrillo, Josepa Mauri, Carlos Labata, Carolina Oliete, Maria del Carmen Rivas, Antoni Bayes-Genis Tags: Coronary Artery Disease Source Type: research

Recurrent Myocardial Infarction After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
In conclusion, recurrent MI after PPCI remains a relatively common complication in contemporary practice and confers a significantly increased risk of death, stroke, and bleeding.
Source: The American Journal of Cardiology - November 4, 2013 Category: Cardiology Authors: Wouter J. Kikkert, Loes P. Hoebers, Peter Damman, Krystien V.V. Lieve, Bimmer E.P.M. Claessen, Marije M. Vis, Jan Baan, Karel T. Koch, Robbert J. de Winter, Jan J. Piek, Jan G.P. Tijssen, Jose P.S. Henriques Tags: Coronary Artery Disease Source Type: research

Impact of Hemodynamic Support With Impella 2.5 Versus Intra-Aortic Balloon Pump on Prognostically Important Clinical Outcomes in Patients Undergoing High-Risk Percutaneous Coronary Intervention (from the PROTECT II Randomized Trial)
In conclusion, hemodynamic support with Impella compared with IABP during high-risk PCI in the PROTECT-II trial resulted in improved event-free survival at 3-month follow-up; this finding was further supported by multivariate analyses.
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: George D. Dangas, Annapoorna S. Kini, Samin K. Sharma, Jose P.S. Henriques, Bimmer E. Claessen, Simon R. Dixon, Joseph M. Massaro, Igor Palacios, Jeffrey J. Popma, E. Magnus Ohman, Gregg W. Stone, William W. O'Neill Tags: Coronary Artery Disease Source Type: research

Association Between Intraprocedural Thrombotic Events and Adverse Outcomes After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction (a Harmonizing Outcomes With RevasculariZatiON and Stents in Acute Myocardial Infarction HORIZONS-AMI Substudy)
The present study sought to determine the extent to which adverse angiographic events encountered during percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) are associated with adverse clinical outcomes. Patients with STEMI represent a cohort at particularly high risk of intraprocedural thrombotic events (IPTEs). The overall frequency and implications of IPTEs occurring in patients with STEMI have not been systematically quantified in previous studies. A total of 3,163 patients undergoing primary percutaneous coronary intervention with stent implantation for STEMI in the Harmonizing Ou...
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Ajay J. Kirtane, Prabhdeep Sandhu, Roxana Mehran, Margaret McEntegart, Ecaterina Cristea, Sorin J. Brener, Ke Xu, Martin Fahy, Philippe Généreux, Jeffrey D. Wessler, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research

Comparison of Procedural Complications With Versus Without Interventional Cardiology Fellows-in-Training During Contemporary Percutaneous Coronary Intervention
In conclusion, in contemporary practice at a large academic medical center, PCI complication rates were not adversely affected by the presence of an ICFIT.
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Joshua M. Stolker, Drew S. Allen, David J. Cohen, Kevin F. Kennedy, Steven B. Laster, Andrew D. Frutkin, Sameer K. Mehta, Kelly R. O'Neal, Steven P. Marso Tags: Coronary Artery Disease Source Type: research

Comparison of Outcomes for Patients ≥75 Years of Age Treated With Pre-Hospital Reduced-Dose Fibrinolysis Followed by Percutaneous Coronary Intervention Versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction
A coordinated system of care for patients with ST-segment elevation myocardial infarctions that includes prehospital administration of reduced-dose fibrinolytic agents coupled with urgent percutaneous coronary intervention (PCI), termed FAST-PCI, has been shown to be at least as effective as primary PCI (PPCI) alone. However, this reduced-dose fibrinolytic strategy could be associated with increased bleeding risk, especially in elderly patients. The purpose of this study was to examine 30-day outcomes in patients aged ≥75 years with ST-segment elevation myocardial infarctions treated with either strategy. Data from 120 p...
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Amirreza Solhpour, Kay-Won Chang, Prakash Balan, Chunyan Cai, Stefano Sdringola, Ali E. Denktas, Richard W. Smalling, H. Vernon Anderson Tags: Coronary Artery Disease Source Type: research

Treatment Patterns and Outcomes in Patients Undergoing Percutaneous Coronary Intervention Treated With Prasugrel or Clopidogrel (from the Swedish Coronary Angiography and Angioplasty Registry SCAAR)
In conclusion, in this real world population of patients who underwent urgent or elective PCI, prasugrel was used mainly in patients with ACS, while it was avoided in patients with characteristics indicating increased bleeding risk. Mortality and bleeding rates were lower with prasugrel than clopidogrel, probably because of patient selection.
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Peter Damman, Christoph Varenhorst, Sasha Koul, Peter Eriksson, David Erlinge, Bo Lagerqvist, Stefan K. James Tags: Coronary Artery Disease Source Type: research

Contemporary Analysis of Incidence and Outcomes of Stent Thrombosis Presenting as ST Elevation Myocardial Infarction in a Primary Percutaneous Coronary Intervention Cohort
There are limited data about the effectiveness of primary percutaneous coronary intervention (PPCI) for stent thrombosis treatment. We aimed to evaluate the prevalence and outcomes of PPCI in patients with ST elevation acute myocardial infarction (STEMI) due to stent thrombosis, and comparing the outcomes with patients treated for de novo coronary thrombosis. This was an observational cohort study of 2,935 patients who underwent PPCI from 2003 to 2011 with follow-up for a median of 3.0 years (interquartile range 1.2 to 4.6). The primary end point was the first major adverse cardiac event (MACE) defined as death, nonfatal ...
Source: The American Journal of Cardiology - September 9, 2013 Category: Cardiology Authors: Daniel A. Jones, Sean Gallagher, Krishnaraj S. Rathod, Mohammed Akhtar, Charles J. Knight, Martin T. Rothman, Akhil Kapur, Anthony Mathur, Ajay K. Jain, Adam D. Timmis, Elliot J. Smith, Andrew Wragg Tags: Coronary Artery Disease Source Type: research

Outcome of Percutaneous Coronary Intervention Following Recent Surgery
The objective of this study was to determine clinical outcomes of patients undergoing PCI within 7 days after a surgical procedure. We assessed outcomes of 517 patients who underwent PCI within 7 days after a surgery across 44 hospitals from January 2010 to December 2011 from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium registry. Patients with postoperative PCI were compared with all other patients with PCI using propensity-matched analysis. Of the 65,175 patients who underwent PCI within the study period, 517 patients had undergone surgery within the previous 7 days. In unadjusted analysis, patients...
Source: The American Journal of Cardiology - September 3, 2013 Category: Cardiology Authors: John R. Hoyt, Milan Seth, Ivan Hanson, Simon Dixon, David Share, Thomas Lalonde, David Wohns, Mauro Moscucci, Hitinder S. Gurm Tags: Coronary Artery Disease Source Type: research

Impact of Bivalirudin and Paclitaxel-Eluting Stents on Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention of the Left Anterior Descending Artery
In conclusion, in patients with STEMI who underwent primary PCI of LAD, the use of bivalirudin was associated with a reduction in mortality and bleeding rates at 3 years. PES reduced revascularization rates in this population but did not have a significant impact on mortality.
Source: The American Journal of Cardiology - June 10, 2013 Category: Cardiology Authors: Jochen Wöhrle, Bruce Brodie, Bernhard Witzenbichler, Dariusz Dudek, Ran Kornowski, Chris Metzger, Cindy Grines, Thomas C. McAndrew, Helen Parise, Ziad Sergie, Roxana Mehran, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research

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