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Total 204 results found since Jan 2013.
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances
Adv Cancer Res. 2022;156:415-449. doi: 10.1016/bs.acr.2022.01.013. Epub 2022 Feb 18.ABSTRACTOver the past several decades, primary liver cancer (PLC), mostly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), has become the focus of rising concern mainly due to the increasing rates of incidence and high global mortality. Immunotherapy, as an emerging treatment approach, represents an effective and promising option against PLC. However, the selection of immunotherapeutic targets while considering tumor heterogeneity and immunosuppressive tumor microenvironment is a major challenge. The purpose of thi...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Dan Li Shaoli Lin Jessica Hong Mitchell Ho Source Type: research
Implications of genetic heterogeneity in hepatocellular cancer
Adv Cancer Res. 2022;156:103-135. doi: 10.1016/bs.acr.2022.01.007. Epub 2022 Mar 7.ABSTRACTHepatocellular carcinoma (HCC) exhibits a remarkable degree of heterogeneity, not only at an inter-patient level but also between and within tumors in the same patient. The advent of next-generation sequencing (NGS)-based technologies has allowed the creation of high-resolution atlases of HCC. This review outlines recent findings from genomic, epigenomic, transcriptomic, and proteomic sequencing that have yielded valuable insights into the spatial and temporal heterogeneity of HCC. The high heterogeneity of HCC has both clinical and ...
Source: Advances in Cancer Research - August 12, 2022 Category: Cancer & Oncology Authors: Akanksha Suresh Renumathy Dhanasekaran Source Type: research
