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Source: Advances in Cancer Research
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Total 442 results found since Jan 2013.

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research

PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research

Tumor heterogeneity: An oncogenic driver of PDAC progression and therapy resistance under stress conditions
Adv Cancer Res. 2023;159:203-249. doi: 10.1016/bs.acr.2023.02.005. Epub 2023 Apr 21.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a clinically challenging disease usually diagnosed at advanced or metastasized stage. By this year end, there are an expected increase in 62,210 new cases and 49,830 deaths in the United States, with 90% corresponding to PDAC subtype alone. Despite advances in cancer therapy, one of the major challenges combating PDAC remains tumor heterogeneity between PDAC patients and within the primary and metastatic lesions of the same patient. This review describes the PDAC subtypes based on the genom...
Source: Advances in Cancer Research - June 2, 2023 Category: Cancer & Oncology Authors: Ant ónio M Palma Vignesh Vudatha Maria Leonor Peixoto Esha Madan Source Type: research