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The most prominent modulated annexins during parasitic infections
Acta Trop. 2023 May 10:106942. doi: 10.1016/j.actatropica.2023.106942. Online ahead of print.ABSTRACTAnnexins (ANXs) exert different functions in cell biological and pathological processes and are thus known as double or multi-faceted proteins. These sophisticated proteins might express on both parasite structure and secretion and in parasite-infected host cells. In addition to the characterization of these pivotal proteins, describing their mechanism of action can be also fruitful in recognizing their roles in the pathogenesis of parasitic infections. Accordingly, this study presents the most prominent ANXs thus far ident...
Source: Acta Tropica - May 12, 2023 Category: Infectious Diseases Authors: Sajad Rashidi Reza Mansouri Mohammad Ali-Hassanzadeh Antonio Muro Paul Nguewa Ra úl Manzano-Román Source Type: research

Potential of recombinant LiHyQ, a novel Leishmania infantum protein, for the diagnosis of canine visceral leishmaniasis and as a diagnostic and prognostic marker for human leishmaniasis and human immunodeficiency virus co-infection: a preliminary study
In conclusion, our preliminary data suggest a diagnostic and prognostic role for rLiHyQ against leishmaniasis.PMID:34537185 | DOI:10.1016/j.actatropica.2021.106126
Source: Acta Tropica - September 19, 2021 Category: Infectious Diseases Authors: Tha ís T O Santos Fernanda F Ramos Isabela A P Gon çalves Grasiele S V Tavares Fernanda Ludolf Raquel S Bandeira Alessandra M Silva Jo ão A Oliveira-da-Silva Thiago A R Reis Amanda S Machado Daniela P Lage Camila S Freitas Danniele L Vale V ívian T Ma Source Type: research

A brief history of selected malaria vaccine and medical interventions pursued by the Swiss Tropical and Public Health Institute and partners, 1943-2021
This article does not present new scientific data but takes a historical perspective. Its aim is to highlight the above-mentioned transformation by focusing on selected malaria research-cum-action interventions during the crucial period of the 1990s, which were tailored to the social-ecological settings where the disease was endemic. In order for this transformation to be successful, we intend to emphasise the importance of (i) having a fundamental understanding of local transmission; (ii) building and nurturing relationships with partner institutions; and (iii) developing a coherent research portfolio as key elements for ...
Source: Acta Tropica - August 31, 2021 Category: Infectious Diseases Authors: Lukas Meier Giovanni Casagrande Salim Abdulla Honorati Masanja Source Type: research

Enzymatic Characteristics and Preventive Effect of Leucine Aminopeptidase Against Echinococcus multilocularis
In this study, the bioinformatic and enzymatic characterizations of recombinant Echinococcus multilocularis LAP (rEm-LAP) were evaluated. A prokaryotic expression system for rEm-LAP protein was established and its immunogenicity and preventive efficacy were demonstrated in a BALB/c mice model. This is the first report about the LAP of Echinococcus multilocularis and with a 57.4 KD purified rEm-LAP protein successfully expressed by pCzn1-LAP in Escherichia coli BL-21 cells. Enzymatic analysis results showed optimal rEm-LAP activity at pH 9. Serum indirect ELISA demonstrated that rEm-LAP could induce a Th1 and Th2 mixed-type...
Source: Acta Tropica - July 25, 2021 Category: Infectious Diseases Authors: Lei Wang Wei Wei Pei Zhou Haisheng Liu Baoliang Yang Lin Feng Ri-Li Ge Runle Li Feng Tang Source Type: research