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Effectiveness of Atomoxetine (Strattera) for the Treatment of Poststroke Aphasia Combined With Cognitive Impairment
Conclusions Atomoxetine has been shown to significantly improve cognitive function and language in patients with poststroke aphasia. It is also the first study to report improvement in auditory comprehension and naming by administration of atomoxetine.
Source: Clinical Neuropharmacology - March 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Ischemic Stroke and Provoked Seizure as a Manifestation of Brugmansia suaveolens (Angel's Trumpet) Acute Intoxication: A Detailed Clinical, Electroencephalogram, and Magnetic Resonance Imaging Description and 5-Month Follow-up
Conclusions Angel's trumpet intoxication is a neurological emergency that deserves attention of both the media in matter of plant poisoning and the scientific forums because of the high lethal potential to better choose the diagnostic and therapeutic process.
Source: Clinical Neuropharmacology - November 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Conclusions Our results suggest the effect of lomerizine on preventing secondary stroke in CADASIL patients.
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

A Case of Abulia From Left Middle Cerebral Artery Stroke in an Adolescent Treated Successfully With Short Duration Olanzapine
Conclusion Further research is needed to develop a better understanding of the pathophysiology of abulia leading to more effective treatment algorithms including more specific diagnostic tools and effective pharmacological interventions.
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Effect of Duloxetine for the Treatment of Chronic Central Poststroke Pain
Conclusions Our findings suggest that duloxetine can be effective for managing CPSP.
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Treatment of Poststroke Pathologic Laughing With Duloxetine: A Case Series
Conclusions This case series demonstrates that duloxetine could attenuate pathologic laughing exhibited by stroke patients; however, further randomized controlled studies are necessary to validate our findings.
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Cerebral Microbleeds and the Safety of Anticoagulation in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
Conclusions The presence of CMBs increases the risk of ICH during anticoagulant treatment (especially warfarin) in IS patients. Further studies with larger numbers of patients are needed to confirm our conclusions.
Source: Clinical Neuropharmacology - November 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature
Conclusions Our case exemplifies the need to raise awareness about the risk of ischemic stroke associated with MM that might be increased by treatment with lenalidomide and to establish consistent recommendations regarding thromboprophylaxis to reduce comorbidities and mortality in these patients.
Source: Clinical Neuropharmacology - November 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Recanalization of Chronic Occlusion of the Middle Cerebral Artery With Tissue Plasminogen Activator Treatment: A Case Report
Conclusions At present, tPA is the only approved treatment for acute ischemic stroke, although it presents a limited time frame to avoid severe medication-related adverse effects. Our report suggests nonatherosclerotic chronic MCA occlusion as an alternative application of tPA therapy.
Source: Clinical Neuropharmacology - July 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes
We report a case in which an adult patient with MELAS and comorbid major depressive disorder demonstrated excellent response to the selective serotonin-norepinephrine reuptake inhibitor medication duloxetine.
Source: Clinical Neuropharmacology - May 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Thrombolytic Therapy in Wake-Up Stroke Patients
Conclusions: Available data suggest promising strategies to identify WUS patients who may benefit from thrombolysis. Once on-going trials are complete, there may be sufficient information to redefine tPA eligibility for previously excluded patients.
Source: Clinical Neuropharmacology - May 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Epigallocatechin Gallate Extends Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment for Brain Ischemic Stroke: A Randomized Double-Blind and Placebo-Controlled Trial
Conclusions: Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients, particularly those with delayed OTT, to extend the otherwise narrow therapeutic window and improve the outcome in late stroke treatment.
Source: Clinical Neuropharmacology - January 1, 2017 Category: Neurology Tags: Original Articles Source Type: research

Pisa-Like Syndrome Under Baclofen in a Patient With Spastic Hemiparesis due to Ischemic Stroke
Abstract: In its original description, Pisa syndrome was reported as an iatrogenic dystonia of the trunk caused by neuroleptic drugs. However, sometimes, not dystonic lateral flexion of the trunk is described as Pisa syndrome. These observations support the possibility of a drug-induced lateral flexion of the trunk with clinical presentation similar to Pisa syndrome, although with a different etiology and pathophysiology. Here, we describe the case of a male patient, with a previous ischemic stroke and residual spastic hemiparesis to the right side, who subacutely developed a dramatic lateral flexion of trunk (approximatel...
Source: Clinical Neuropharmacology - September 1, 2015 Category: Neurology Tags: Case Reports Source Type: research

Effect of Donepezil on Wernicke Aphasia After Bilateral Middle Cerebral Artery Infarction: Subtraction Analysis of Brain F-18 Fluorodeoxyglucose Positron Emission Tomographic Images
We present a case of a 53-year-old female patient with Wernicke aphasia, after the old infarction in the territory of left middle cerebral artery for 8 years and the recent infarction in the right middle cerebral artery for 4 months. On the initial evaluation, the Aphasia Quotient in Korean version of the Western Aphasia Battery was 25.6 of 100. Baseline brain F-18 fluorodeoxyglucose positron emission tomographic images demonstrated a decreased cerebral metabolism in the left temporoparietal area and right temporal lobe. Donepezil hydrochloride, a reversible acetylcholinesterase inhibitor, was orally administered 5 mg/d fo...
Source: Clinical Neuropharmacology - July 1, 2015 Category: Neurology Tags: Case Reports Source Type: research

How to Manage Thrombolysis Interruptions in Acute Stroke?
Conclusions: These results strongly suggest avoiding bolus-infusion delays by giving the bolus only when the infusion is ready. In case of a delayed start of the infusion, the possibilities are restricted to do nothing or to give a second bolus. We have estimated the dosing of the second bolus depending on the duration of the delay/interruption to allow for the achievement of appropriate serum t-PA concentrations. However, clinical safety data are needed to recommend the application of a second bolus.
Source: Clinical Neuropharmacology - May 1, 2015 Category: Neurology Tags: Original Articles Source Type: research

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