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Source: Neurosurgery
Procedure: Angiography
Therapy: Stem Cell Therapy
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De Novo Arteriovenous Malformation Growth Secondary to Implantation of Genetically Modified Allogeneic Mesenchymal Stem Cells in the Brain
CONCLUSION: The development of an AVM within a period of 3 years after implantation of the glucagon-like peptide-1–secreting mesenchymal stem cells suggests a possible relationship. This case exemplifies that further investigations are necessary to assess the safety of genetically modified cell lines for local biological drug delivery in the brain.
ABBREVIATIONS: ALK1, activin-like kinase 1
AVM, arteriovenous malformation
ENG, endoglin; GLP-1, glucagon-like peptide-1
GLP-1R, glucagon-like peptide-1 receptor
MSC, mesenchymal stem cell
Source: Neurosurgery - March 22, 2016 Category: Neurosurgery Tags: Case Report Source Type: research
