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Excess Stroke Deaths in Kidney Transplant Recipients: A Retrospective Population-based Cohort Study Using Data Linkage
Conclusions. Kidney transplant recipients had excess stroke deaths, particularly at younger ages and women. Preexisting cerebrovascular disease was a potentially modifiable risk factor for stroke death, suggesting further studies of secondary stroke prevention for kidney transplant recipients.
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Intraoperative Hemodynamic Parameters and Acute Kidney Injury After Living Donor Liver Transplantation
Conclusions. The elevated baseline CVP, elevated baseline RVEDV after anesthesia induction, and decreased SvO2 during anhepatic phase were associated with postoperative AKI. Prospective trials are required to evaluate whether the optimization of these variables may decrease the risk of AKI after LDLT.
Source: Transplantation - August 29, 2019 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Solid Organ Transplant Donors With Central Nervous System Infection
ConclusionCareful clinical assessment of donors combined with a high index of suspicion for ambiguous or misleading findings associated with CNS infection can reduce, but not eliminate, DDI with CNS pathogens.
Source: Transplantation - September 27, 2014 Category: Transplant Surgery Tags: Clinical and Translational Research Source Type: research

Liver Transplantation With Older Donors: A Comparison With Younger Donors in a Context of Organ Shortage
Conclusions: Provided normal liver tests and the absence of cardiac arrest in donors, older liver grafts (>75 years) may be safely attributed to non–hepatitis C-infected recipients in the setting of a first and nonurgent transplantation.
Source: Transplantation - October 28, 2016 Category: Transplant Surgery Tags: Original Clinical Science-Liver Source Type: research

The Risk of Cardiovascular Disease Is Not Increasing Over Time Despite Aging and Higher Comorbidity Burden of Kidney Transplant Recipients
Conclusion: Despite transplant centers accepting recipients who are older with more comorbidities in recent years, the 3-year cumulative incidence of death or major cardiovascular event has remained stable over time.
Source: Transplantation - February 23, 2017 Category: Transplant Surgery Tags: Original Clinical Science-General Source Type: research

Cardiovascular Disease Outcomes Related to Early Stage Renal Impairment After Liver Transplantation
Background In the general population, even mild renal disease is associated with increased cardiovascular (CV) complications. Whether this is true in liver transplant recipients (LTR) is unknown. Methods This was a retrospective cohort study of 671 LTR (2002-2012) from a large urban tertiary care center and 37 322 LTR using Vizient hospitalization data linked to the United Network for Organ Sharing. The 4-variable Modification of Diet in Renal Disease equation estimated glomerular filtration rate (eGFR). Outcomes were 1-year CV complications (death/hospitalization from myocardial infarction, heart failure, atrial fibr...
Source: Transplantation - June 29, 2018 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Muscle Mass and Mortality After Cardiac Transplantation
Conclusions Muscle mass is an independent predictor of mortality and major morbidity after OHT. Further research is needed to determine whether frail OHT patients with low PMA may benefit from muscle-building interventions to improve outcomes.
Source: Transplantation - November 22, 2018 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

VCA Deceased Donors in the United States
Conclusions. donors are a demographically and clinically diverse group. Understanding this diversity and future trends in VCA donor characteristics is critical in supporting this life-changing field of transplantation.
Source: Transplantation - May 1, 2019 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Comparing Donor Heart Assessment Strategies During Ex Situ Heart Perfusion to Better Estimate Posttransplant Cardiac Function
Conclusions. Left ventricular functional parameters, especially ventricular work and reserve, provided the best estimation of myocardial performance following transplantation. Furthermore, simple NI estimates of ventricular function proved useful in this setting. Right ventricular and metabolic measurements were limited in their ability to correlate with myocardial recovery. This emphasizes the need for an ESHP platform capable of assessing myocardial contractility and suggests that metabolic parameters alone do not provide a reliable evaluation.
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

The Clinical Conundrum of Cannabis: Current Practices and Recommendations for Transplant Clinicians: An Opinion of the Immunology/Transplantation PRN of the American College of Clinical Pharmacy
Cannabis, or marijuana, comprises many compounds with varying effects. It has become a treatment option for chronic diseases and debilitating symptoms, and evidence suggests that it has immunomodulatory and antiinflammatory properties. Transplant centers are more frequently facing issues about cannabis, as indications and legalization expand. As of February 2020, 33 states and the District of Columbia have legalized medical cannabis, and 14 have legalized recreational cannabis. Moreover, 8 states have passed legislation prohibiting the denial of transplant listing solely based on cannabis use. Studies demonstrate the poten...
Source: Transplantation - January 30, 2021 Category: Transplant Surgery Tags: Reviews Source Type: research

The Impact of Donor Asphyxiation or Drowning on Pediatric Lung Transplant Recipients
Conclusions. This study evaluated the impact of DA MOD donors in pediatric lung transplant recipients and found similar rates of complications and survival in a propensity-matched cohort. These data collectively support the consideration of DA MOD donors for use in pediatric lung transplantation.
Source: Transplantation - March 1, 2021 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Major Thromboembolic Complications in Liver Transplantation: The Role of Rotational Thromboelastometry and Cryoprecipitate Transfusion
Background. Although hemorrhage is a major concern during liver transplantation (LT), the risk for thromboembolism is well recognized. Implementation of rotational thromboelastometry (ROTEM) has been associated with the increased use of cryoprecipitate; however, the role of ROTEM-guided transfusion strategy and cryoprecipitate administration in the development of major thromboembolic complications (MTCs) has never been documented. Methods. We conducted a study on patients undergoing LT before and after the implementation of ROTEM. We defined MTC as intracardiac thrombus, pulmonary embolism, hepatic artery thromb...
Source: Transplantation - July 28, 2021 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research