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Source: Journal of Hypertension

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Total 283 results found since Jan 2013.

Isolated systolic and diastolic hypertension by the 2017 American College of Cardiology/American Heart Association guidelines and risk of cardiovascular disease: a large prospective cohort study
Objective: The 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines lowered the hypertension threshold from a SBP/DBP level of at least 140/90 mmHg to at least 130/80 mmHg. The cardiovascular impact of isolated systolic hypertension (ISH) and isolated diastolic hypertension (IDH) under the new definition remains unclear. Methods: We used data from the UK Biobank study, which is a prospective population-based cohort study. Participants were categorized into five groups: normal BP, normal high BP, ISH, IDH and systolic and diastolic hypertension. The primary endpoint fo...
Source: Journal of Hypertension - July 9, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Neurologically asymptomatic patients frequently present cerebral injuries during malignant hypertension: a MRI study
Conclusion: PRES, recent hematoma, ischemic stroke and severe cerebral microangiopathy are common findings in MHT patients without neurological signs on admission. The impact of these findings on patient management, and their cerebrovascular and cognitive prognostic value, should be established. Brain MRI might need to become systematic in patients suffering from MHT episodes.
Source: Journal of Hypertension - November 19, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Changes in blood pressure and cardiovascular disease in middle-aged to older Chinese: the Guangzhou Biobank Cohort Study
Conclusion: Most people between 50 and 70 years of age and not taking antihypertensive medication maintained a slow increase SBP trajectory over a follow-up period of approximately 7 years. However, those whose SBPs increased from low and moderate levels were associated with higher CVD risks.
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Sex differences in cardiovascular outcomes in patients with incident hypertension
Conclusion: In this cohort with incident hypertension, women were more likely to develop CKD and less likely to develop other cardiovascular outcomes compared with men. Future studies should investigate the potential reasons for these sex differences.
Source: Journal of Hypertension - January 11, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Blood pressure in professional male football players in Norway
Conclusion: Although the prevalence of high BP in professional football players was low, our data indicate a novel association between elevated BP and reduced arterial compliance, increased left ventricle mass and left atrium volume even in young athletes. This emphasizes closer focus on BP measurements and standardized follow-up after preparticipation screening of athletes.
Source: Journal of Hypertension - March 9, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Systolic left ventricular function according to left ventricular concentricity and dilatation in hypertensive patients: the Losartan Intervention For Endpoint reduction in hypertension study
Background:Left ventricular hypertrophy [LVH, high left ventricular mass (LVM)] is traditionally classified as concentric or eccentric based on left ventricular relative wall thickness. We evaluated left ventricular systolic function in a new four-group LVH classification based on left ventricular dilatation [high left ventricular end-diastolic volume (EDV) index and concentricity (LVM/EDV(2/3))] in hypertensive patients. Methods and results:Nine hundred thirty-nine participants in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) echocardiography substudy had measurable LVM at enrolment. Patients wit...
Source: Journal of Hypertension - September 11, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life
Objectives:We assessed whether hypertension in pregnancy is associated with elevated C-reactive protein (CRP) levels in later life, possibly reflecting an increased risk of cardiovascular disease (CVD). Background:Elevated CRP levels have been associated with hypertension in pregnancy and with CVD. Methods:We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Participants were categorized as nulliparous women (n = 219), women with a history of normotensive pregnancies (n = 1839), or women with a history of a hypertensive pregnancy (n = 405). Using multiple linear regression ...
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Pregnancy Source Type: research

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death
Conclusion:The NEDD4L salt sensitivity-associated genotype was associated with higher blood pressure, which may translate into increased risk for CVD morbidity and mortality. Interestingly, there was no association with stroke suggesting that the association is partially blood pressure independent.
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Genetic aspects Source Type: research

Systolic blood pressure variability is an important predictor of cardiovascular outcomes in elderly hypertensive patients
Conclusion:These findings suggest that reducing visit-to-visit SBP variability might be an important objective in addition to conventional blood pressure-lowering in elderly hypertensive patients.
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: BP variability Source Type: research

Cost-effectiveness of Barostim therapy for the treatment of resistant hypertension in European settings
Conclusion:Barostim may be a cost-effective treatment when compared with optimal medical management in patients with resistant hypertension.
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Hypertension management Source Type: research

Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?
Conclusion:Our study showed that right-ventricular and right atrial mechanics, as well as exercise capacity, are significantly deteriorated in the hypertensive patients who are untreated or ineffectively treated. Global right-ventricular strain and 3DE right-ventricular stroke volume are independently associated with functional capacity in the whole study population.
Source: Journal of Hypertension - March 11, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research

Impact of telmisartan on cardiovascular outcome in hypertensive patients at high risk: a Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease subanalysis
Background:In the Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease, all patients were at high cardiovascular risk, and a substantial proportion were hypertensive. We performed a post-hoc analysis to explore the hypothesis that telmisartan has a differential action in hypertensive vs. nonhypertensive patients. Methods:The primary four-fold endpoint (composite of cardiovascular death, myocardial infarction (MI), stroke, or hospitalization for heart failure), the secondary three-fold endpoint (cardiovascular death, MI, and stroke), the individual components, new onset of left vent...
Source: Journal of Hypertension - May 1, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis
Conclusion: B. oleracea administration prevented renal damage in salt-loaded SHRSP, independently from SBP, with parallel stimulation of AMPK/SIRT1/PGC1α/PPARα/UCP2 axis. Stimulation of the latter mechanism may provide relevant renal protective effect and play a therapeutic role in target organ damage progression in hypertension.
Source: Journal of Hypertension - June 5, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research

Retinal vessel calibres and haemostasis in black and white South Africans: the SABPA study
Conclusion: Relationships between markers of haemostasis and the retinal vessel calibres exist, and vary between ethnicities. Haemostatic alterations are linked to early retinal microvascular changes, and future studies should investigate whether it translates into an elevated stroke risk.
Source: Journal of Hypertension - November 12, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Retina Source Type: research

Silent brain infarcts in high blood pressure patients with cardiac implantable electronic devices: unmasking silent atrial fibrillation
Background: Hypertensive patients present a higher risk for developing atrial fibrillation and its complications. Cardiac implantable electronic devices (CIEDs) have shown reliable atrial fibrillation detection as atrial high-rate episodes (AHREs). The presence of AHRE more than 5 min has been related to increased risk of stroke, but a high proportion of ischemic brain lesions (IBLs) could be subclinical and thromboembolic risk underestimated. Methods: We included hypertensive patients with CIED and we analyzed the incidence of AHRE and the presence of IBL on computed tomography (CT) scan. Results: One hundred and twenty...
Source: Journal of Hypertension - December 23, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research