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Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Drugs & Pharmacology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research

Trimethylamine N-Oxide as a potential risk factor for non-communicable diseases: A systematic review
CONCLUSION: There is a dose-response relationship between TMAO levels and NCDs progression. Therefore, it can be studied as a therapeutic target or prognostic biomarker for dealing with NCDs.PMID:36330632 | DOI:10.2174/1871530323666221103120410
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 4, 2022 Category: Drugs & Pharmacology Authors: Zahra Hoseini Tavassol Hanieh-Sadat Ejtahed Bagher Larijani Shirin Hasani-Ranjbar Source Type: research

The Potential Role of Naringin and Naringenin as Nutraceuticals against Metabolic Syndrome
Endocr Metab Immune Disord Drug Targets. 2022 Aug 27. doi: 10.2174/1871530322666220827141203. Online ahead of print.ABSTRACTMetabolic syndrome, an increasing problem in western society, is a cluster of conditions which affects cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proved anti-inflammatory activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal mechanisms b...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 31, 2022 Category: Drugs & Pharmacology Authors: Luca Massaro Anna Raguzzini Paola Aiello D ébora Villaño Valencia Source Type: research

Prognostic significance of hypertriglyceridemia in patients at high and very high cardiovascular risk depending on the concentration of high-sensitivity C-reactive protein
CONCLUSION: In patients with high and very high CVR, an increase in TG ≥2.3 mmol/L was associated with the development of adverse cardiovascular events only in the subgroup of patients with an increase in hsCRP ≥2.0 mg/L. The presence of HTG was associated with 4.63 times increase in RR of adverse cardiovascular events (95% CI 1.35-15.8; p=0.015).PMID:35490328 | DOI:10.2174/1871530322666220427094330
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 1, 2022 Category: Drugs & Pharmacology Authors: Vadim Genkel Alla Kuznetcova Lubov Pykhova Karina Nikushkina Albina Savochkina Ilya Dolgushin Igor Shaposhnik Source Type: research

Pain and muscles properties modifications after botulinum toxin type A (BTX-A) and radial Extracorporeal Shock Wave (rESWT) combined treatment.
CONCLUSIONS: Radial Extracorporeal Shock Wave Therapy could be an effective physical treatment aimed at the reduction of upper and lower limbs spasticity and could lead to the improvement of trophic conditions of the spastic muscles in post-stroke. PMID: 30843498 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Identification of novel pancreatic lipase inhibitors using structure based virtual screening, docking and simulations studies.
CONCLUSION: Thus, we anticipate that results could be future therapeutic agents and may present an idea toward the experimental studies against the inhibition of pancreatic lipase. PMID: 30484411 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 30, 2018 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Extra virgin olive oil and cardiovascular diseases: benefits for human health.
CONCLUSION: The studies analyzed demonstrated the role of EVOO as anti-inflammatory, antioxidant and vasodilatory nutrient that may contribute to lower the atherosclerotic burden. PMID: 29141571 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 17, 2017 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Hypopituitarism in neurocritical patients: A Case Report.
We report a case of a 72-year-old woman showing clinical signs and laboratory data suggesting a secondary adrenal insufficiency following a recent acute brain ischemia. Cortisone therapy significantly improved this pituitary dysfunction. Therefore, clinicians must pay attention to the hypothalamic-pituitary axis in neurocritical patients because hormonal replacement therapy may be life-saving. PMID: 26420547 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 3, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research