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Cardiovascular/Stroke Risk Stratification in Parkinson's Disease Patients Using Atherosclerosis Pathway and Artificial Intelligence Paradigm: A Systematic Review
Metabolites. 2022 Mar 31;12(4):312. doi: 10.3390/metabo12040312.ABSTRACTParkinson's disease (PD) is a severe, incurable, and costly condition leading to heart failure. The link between PD and cardiovascular disease (CVD) is not available, leading to controversies and poor prognosis. Artificial Intelligence (AI) has already shown promise for CVD/stroke risk stratification. However, due to a lack of sample size, comorbidity, insufficient validation, clinical examination, and a lack of big data configuration, there have been no well-explained bias-free AI investigations to establish the CVD/Stroke risk stratification in the P...
Source: Atherosclerosis - April 21, 2022 Category: Cardiology Authors: Jasjit S Suri Sudip Paul Maheshrao A Maindarkar Anudeep Puvvula Sanjay Saxena Luca Saba Monika Turk John R Laird Narendra N Khanna Klaudija Viskovic Inder M Singh Mannudeep Kalra Padukode R Krishnan Amer Johri Kosmas I Paraskevas Source Type: research

Cardiovascular/Stroke Risk Assessment in Patients with Erectile Dysfunction-A Role of Carotid Wall Arterial Imaging and Plaque Tissue Characterization Using Artificial Intelligence Paradigm: A Narrative Review
Diagnostics (Basel). 2022 May 17;12(5):1249. doi: 10.3390/diagnostics12051249.ABSTRACTPURPOSE: The role of erectile dysfunction (ED) has recently shown an association with the risk of stroke and coronary heart disease (CHD) via the atherosclerotic pathway. Cardiovascular disease (CVD)/stroke risk has been widely understood with the help of carotid artery disease (CTAD), a surrogate biomarker for CHD. The proposed study emphasizes artificial intelligence-based frameworks such as machine learning (ML) and deep learning (DL) that can accurately predict the severity of CVD/stroke risk using carotid wall arterial imaging in ED ...
Source: Atherosclerosis - May 28, 2022 Category: Cardiology Authors: Narendra N Khanna Mahesh Maindarkar Ajit Saxena Puneet Ahluwalia Sudip Paul Saurabh K Srivastava Elisa Cuadrado-Godia Aditya Sharma Tomaz Omerzu Luca Saba Sophie Mavrogeni Monika Turk John R Laird George D Kitas Mostafa Fatemi Al Baha Barqawi Martin Miner Source Type: research

Left ventricular assist device implantation combined with hemiarch replacement for severe aortic atherosclerosis
J Thorac Dis. 2023 Jul 31;15(7):3979-3983. doi: 10.21037/jtd-23-255. Epub 2023 Jul 6.ABSTRACTImplantation of the left ventricular assist device (LVAD) has emerged as a widely employed therapeutic approach for specifically chosen individuals suffering from severe heart failure. Stroke is a well-known complication of LVAD implantation. Concomitant aortic surgeries in patients requiring LVAD implantation to avoid outflow graft anastomosis to a severe atherosclerotic aorta are unknown. We illustrate a successful LVAD implantation with hemiarch replacement for severe aortic atherosclerosis to decrease the risk of postoperative ...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: June Lee Seok Beom Hong Yong Han Kim Hwan Wook Kim Do Yeon Kim Source Type: research

New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases
Tissue Eng Regen Med. 2022 Jul 22. doi: 10.1007/s13770-022-00469-x. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management through their regenerative and paracrine actions. In recent years, many studies have shifted from the use of transplanted stem cells to their secreted exosomes for the management of various CVDs and cardiovascular-related diseases including atherosclerosis, stroke, myocardial infarction, heart failure, peripheral arterial diseases, and pulmonary hypertension. In different m...
Source: Atherosclerosis - July 22, 2022 Category: Cardiology Authors: Lamiaa Ahmed Khaled Al-Massri Source Type: research

Artificial neuronal network analysis in investigating the relationship between oxidative stress and endoplasmic reticulum stress to address blocked vessels in cardiovascular disease
CONCLUSIONS: VPO1 and ATF4 might be potential biomarkers associated with coronary artery disease, especially in the follow-up and monitoring of treatment protocols, in addition to traditional risk factors.PMID:36381079 | PMC:PMC9636495 | DOI:10.5937/jomb0-33855
Source: Atherosclerosis - November 16, 2022 Category: Cardiology Authors: Fatma Kalay Toprak Muhammet Sait Hakan Ekmek çi Mine Kucur Bar ış İkitimur H üseyin Sönmez Zeynep G üngör Source Type: research

Clonal Hematopoiesis and the Heart: a Toxic Relationship
Curr Oncol Rep. 2023 Mar 15. doi: 10.1007/s11912-023-01398-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Clonal hematopoiesis (CH) refers to the expansion of hematopoietic stem cell clones and their cellular progeny due to somatic mutations, mosaic chromosomal alterations (mCAs), or copy number variants which naturally accumulate with age. CH has been linked to increased risk of blood cancers, but CH has also been linked to adverse cardiovascular outcomes.RECENT FINDINGS: A combination of clinical outcome studies and mouse models have offered strong evidence that CH mutations either correlate with or cause atheroscle...
Source: Atherosclerosis - March 15, 2023 Category: Cardiology Authors: Jeffrey L Jensen Saumya Easaw Travis Anderson Yash Varma Jiandong Zhang Brian C Jensen Catherine C Coombs Source Type: research

Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Atherosclerosis - May 4, 2023 Category: Cardiology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research

Atherosclerosis on CT coronary angiography and risk of long-term cardiovascular events post liver transplantation
CONCLUSION: The standardized CAD-RADS classification on CTCA predicted the occurrence of cardiovascular outcomes following LT, with a potential to increase utilization of preventive cardiovascular therapies.PMID:37432891 | DOI:10.1097/LVT.0000000000000215
Source: Atherosclerosis - July 11, 2023 Category: Cardiology Authors: Thalys Sampaio Rodrigues Anoop N Koshy Paul J Gow Laurence Weinberg Benjamin Cailes Adam Testro Gerard Smith Han S Lim Andrew W Teh Ruth P Lim Omar Farouque Source Type: research