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Vitamin K antagonists for stroke prevention in hemodialysis patients with atrial fibrillation: a systematic review and meta-analysis
Conclusion Our meta-analysis revealed a trend for a reduction of the risk of ischemic stroke in hemodialysis patients with AF treated with VKA. The true protective effect may have been underestimated, owing to inclusion of low-risk patients not expected to benefit from anticoagulation and to suboptimal anticoagulation. However, assessment of the overall effect of VKA in hemodialysis patients should also take into account the increased risk of bleeding, in particular of hemorrhagic stroke. Whether new oral anticoagulants provide a better benefit–risk ratio in hemodialysis patients should be the subject of future trials.
Source: American Heart Journal - October 4, 2016 Category: Cardiology Source Type: research

Comparison of different interdialytic intervals among hemodialysis patients on their echocardiogram-based cardiovascular parameters
Conclusions In a selective Japanese outpatient population on maintenance HD, there were no differences in resting cardiovascular function measured by echocardiography at 3 different IDTs. However, exercise-induced afterload mismatch assessed by the changes in Ea, SV, SW, and SW/PVA efficiency was most pronounced in individuals after the long IDT compared with other IDTs. Our findings report potential pathophysiologic echocardiographic parameters that attempt to explain why cardiovascular events are highest on the day after the long IDT compared to other IDTs in dialysis patients.
Source: American Heart Journal - March 10, 2015 Category: Cardiology Source Type: research

Comparison of Different Inter-dialytic Intervals Among Hemodialysis Patients on Their Echocardiogram-Based Cardiovascular Parameters
Conclusions In a selective Japanese outpatient population on maintenance hemodialysis, there were no differences in resting cardiovascular function measured by echocardiography at three different IDTs. However, exercise-induced afterload mismatch assessed by the changes in Ea, SV, SW and SW/PVA efficiency was most pronounced in individuals following the long IDT compared with other IDTs. Our findings report potential pathophysiologic echocardiographic parameters that attempt to explain why cardiovascular events are highest on the day after the long IDT compared to other IDTs in dialysis patients.
Source: American Heart Journal - February 13, 2015 Category: Cardiology Source Type: research