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Source: Vaccine
Vaccination: Malaria Vaccine
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Total 53 results found since Jan 2013.
Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates
Vaccine. 2023 Aug 8:S0264-410X(23)00913-1. doi: 10.1016/j.vaccine.2023.07.067. Online ahead of print.ABSTRACTDevelopment of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding C...
Source: Vaccine - August 10, 2023 Category: Allergy & Immunology Authors: Melanie J Shears Felicia N Watson Brad C Stone Irene Cruz Talavera Chaitra Parthiban Jokichi Matsubara Natasha Kc B Kim Lee Sim Stephen L Hoffman Sean C Murphy Source Type: research
Extending the range of Plasmodium falciparum transmission blocking antibodies
Vaccine. 2023 Apr 24:S0264-410X(23)00453-X. doi: 10.1016/j.vaccine.2023.04.042. Online ahead of print.ABSTRACTRecent work demonstrating that asymptomatic carriers of P. falciparum parasites make up a large part of the infectious reservoir highlights the need for an effective malaria vaccine. Given the historical challenges of vaccine development, multiple parasite stages have been targeted, including the sexual stages required for transmission. Using flow cytometry to efficiently screen for P. falciparum gamete/zygote surface reactivity, we identified 82 antibodies that bound live P. falciparum gametes/zygotes. Ten antibod...
Source: Vaccine - April 26, 2023 Category: Allergy & Immunology Authors: Lacy M Simons Patricia Ferrer Nita Gombakomba Knashka Underwood Raul Herrera David L Narum Gaspar Canepa Festus Acquah Linda Amoah Patrick E Duffy Carolina Barillas-Mury Carole Long Shwu-Maan Lee Emily Locke Kazutoyo Miura Kim C Williamson Source Type: research
Modelling the relative cost-effectiveness of the RTS,S/AS01 malaria vaccine compared to investment in vector control or chemoprophylaxis
CONCLUSIONS: Use of RTS,S results in reductions in malaria cases and deaths even when layered upon existing interventions. When comparing relative cost-effectiveness, scale up of ITNs, introduction of SMC, and switching to new technology nets should be prioritized in eligible settings.PMID:37080831 | DOI:10.1016/j.vaccine.2023.04.011
Source: Vaccine - April 18, 2023 Category: Allergy & Immunology Authors: Hillary M Topazian Nora Schmit Ines Gerard-Ursin Giovanni D Charles Hayley Thompson Azra C Ghani Peter Winskill Source Type: research
Meeting Summary: Global Vaccine and Immunization Research Forum, 2021
Vaccine. 2023 Feb 18:S0264-410X(23)00163-9. doi: 10.1016/j.vaccine.2023.02.028. Online ahead of print.ABSTRACTThe 2021 Global Vaccine and Immunization Research Forum highlighted the considerable advances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, new technology platforms, and vaccines targeting prototype pathogens enabled a rapid, global response. Unprecedented global coordination and partnership h...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Andrew Ford Angela Hwang Annie X Mo Shahida Baqar Nancy Touchette Carolyn Deal Deborah King Kristen Earle Birgitte Giersing Peter Dull B Fenton Hall Source Type: research
A novel high throughput plate-based method for 2-PE quantification in novel multidose vaccines (R21 malaria, Covishield and Covovax) and combination vaccines (Hexavalent)
Vaccine. 2023 Feb 17:S0264-410X(23)00174-3. doi: 10.1016/j.vaccine.2023.02.039. Online ahead of print.ABSTRACTMultidose presentation of vaccines is the most preferred choice, for mass immunization particularly during pandemics. WHO also recommends multidose containers of fill finished vaccines for programmatic suitability and global immunizations programmes. However, multidose vaccine presentations requires inclusion of preservatives to prevent contaminations. 2-Phenoxy ethanol (2-PE) is one such preservative which is being used in numerous cosmetics and many vaccines recently. Estimation of 2-PE content in multidose vials...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Dnyanesh Ranade Rajender Jena Kundan Patil Vikas Dogar Shubham Sancheti Vicky Deore Siddharam Ashtagi Sunil Gairola Source Type: research
Meeting Summary: Global Vaccine and Immunization Research Forum, 2021
Vaccine. 2023 Feb 18:S0264-410X(23)00163-9. doi: 10.1016/j.vaccine.2023.02.028. Online ahead of print.ABSTRACTThe 2021 Global Vaccine and Immunization Research Forum highlighted the considerable advances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, new technology platforms, and vaccines targeting prototype pathogens enabled a rapid, global response. Unprecedented global coordination and partnership h...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Andrew Ford Angela Hwang Annie X Mo Shahida Baqar Nancy Touchette Carolyn Deal Deborah King Kristen Earle Birgitte Giersing Peter Dull B Fenton Hall Source Type: research
A novel high throughput plate-based method for 2-PE quantification in novel multidose vaccines (R21 malaria, Covishield and Covovax) and combination vaccines (Hexavalent)
Vaccine. 2023 Feb 17:S0264-410X(23)00174-3. doi: 10.1016/j.vaccine.2023.02.039. Online ahead of print.ABSTRACTMultidose presentation of vaccines is the most preferred choice, for mass immunization particularly during pandemics. WHO also recommends multidose containers of fill finished vaccines for programmatic suitability and global immunizations programmes. However, multidose vaccine presentations requires inclusion of preservatives to prevent contaminations. 2-Phenoxy ethanol (2-PE) is one such preservative which is being used in numerous cosmetics and many vaccines recently. Estimation of 2-PE content in multidose vials...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Dnyanesh Ranade Rajender Jena Kundan Patil Vikas Dogar Shubham Sancheti Vicky Deore Siddharam Ashtagi Sunil Gairola Source Type: research
Prevalence, determinants, and reasons for malaria vaccine hesitancy among caregivers of under-five children in Nigeria: Results from a nationwide cross-sectional survey
CONCLUSION: The findings of this survey provide a valuable blueprint for the development of targeted interventions to facilitate caregiver acceptance of the RTS,S vaccine.PMID:36725434 | DOI:10.1016/j.vaccine.2023.01.060
Source: Vaccine - February 1, 2023 Category: Allergy & Immunology Authors: Sahabi Kabir Sulaiman Fatimah Isma'il Tsiga-Ahmed Muhammad Sale Musa Abdulwahab Kabir Sulaiman Farouq Muhammad Dayyab Moien Ab Khan Saidu Idris Ahmad Udoyen Abasi-Okot Akpan UmmuKulthum Ibrahim Usman Abdulaziz Tjjani Bako Source Type: research
Cost of introducing and delivering RTS,S/AS01 malaria vaccine within the malaria vaccine implementation program
This study estimates the incremental costs of introducing and delivering the malaria vaccine within routine immunization programs in the context of malaria vaccine pilot introduction, to help inform decision-making.METHODS: An activity-based, retrospective costing was conducted from the governments' perspective. Vaccine introduction and delivery costs supported by the donors during the pilot introduction were attributed as costs to the governments under routine implementation. Detailed resource use data were extracted from the pilot program expenditure and activity reports for 2019-2021. Primary data from representative he...
Source: Vaccine - January 29, 2023 Category: Allergy & Immunology Authors: Ranju Baral Ann Levin Chris Odero Clint Pecenka John Tanko Bawa Kwadwo Odei Antwi-Agyei Kwame Amponsa-Achaino Mike Nenani Chisema Rose Eddah Jalango Rouden Mkisi Scott Gordon Winthrop Morgan Farzana Muhib Source Type: research
