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Vaccination: Cancer Vaccines
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Total 181 results found since Jan 2013.
Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer
Vaccine. 2023 Sep 11:S0264-410X(23)00990-8. doi: 10.1016/j.vaccine.2023.08.047. Online ahead of print.ABSTRACTIndividuals with human papillomavirus (HPV)-related disease remain at risk for subsequent HPV infection and related disease after treatment of specific lesions. Prophylactic HPV vaccines have shown benefits in preventing subsequent HPV-related disease when administered before or soon after treatment. Based on our understanding of the HPV life cycle and vaccine mechanism of action, prophylactic HPV vaccination is not expected to clear active persistent HPV infection or unresected HPV-associated dysplastic tissue rem...
Source: Vaccine - September 13, 2023 Category: Allergy & Immunology Authors: Miriam Reuschenbach John Doorbar Marta Del Pino Elmar A Joura Caroline Walker Rosybel Drury Andreas Rauscher Alfred J Saah Source Type: research
Corrigendum to "Genotype prevalence and age distribution of human papillomavirus from infection to cervical cancer in Japanese women: A systematic review and meta-analysis" Vaccine 40(41) (2022) 5971-5996
Vaccine. 2023 Sep 1:S0264-410X(23)00787-9. doi: 10.1016/j.vaccine.2023.06.084. Online ahead of print.NO ABSTRACTPMID:37659892 | DOI:10.1016/j.vaccine.2023.06.084
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Matthew Palmer Kota Katanoda Eiko Saito Cecilia Acuti Martellucci Shiori Tanaka Sayaka Ikeda Haruka Sakamoto Dorothy Machalek Julia M L Brotherton Jane S Hocking Source Type: research
Real-world challenges in eligibility for MMR vaccination two years after autologous and allogeneic HSCT
Vaccine. 2023 Aug 29:S0264-410X(23)00778-8. doi: 10.1016/j.vaccine.2023.06.075. Online ahead of print.ABSTRACTMeasles outbreaks have raised concerns of fatal infections in immunocompromised patients. Canadian guidelines advise administration of live vaccines, such as measles, mumps, and rubella (MMR), two yearsafter hematopoietic stem cell transplant (HSCT) yet studies have not assessed eligibility based on medication contraindications. We retrospectively reviewed the charts of 72 autologous (auto-HSCT) and 68 allogeneic (allo-HSCT) recipients at the Windsor Regional Cancer Center to determine MMR reactivity and eligibilit...
Source: Vaccine - August 31, 2023 Category: Allergy & Immunology Authors: Gopika Punchhi Rainbow Negus Hammad Saif Sharon Pritchard Olivia Owen Aman Sehmbi Caroline Hamm Source Type: research
Applying the COM-B behaviour model to understand factors which impact school immunisation nurses' attitudes towards designing and delivering a HPV educational intervention in post-primary schools for 15-17 year old students in Northern Ireland, UK
CONCLUSION: IMNs feel that they are the most appropriate professionals to design/deliver HPV education for 15-17 year old students. National policy change, based on collaboration between the Public Health Agency and Education Authority, is a key factor in facilitating IMNs to implement this school-based HPV education intervention.PMID:37543445 | DOI:10.1016/j.vaccine.2023.07.066
Source: Vaccine - August 5, 2023 Category: Allergy & Immunology Authors: Terri Flood Marian McLaughlin Ciara M Hughes Iseult M Wilson Source Type: research
Quadrivalent HPV vaccine effectiveness against anogenital warts: A registry-based study of 2,2 million individuals
CONCLUSIONS: When administered before 14 years of age, qHPV vaccination reduced the probability of AGW about fivefold. The effect decreased sharply with vaccination age, and was not significant among women vaccinated after age 20 years. QHPV administered after the first AGW episode did not protect against a second AGW episode. Herd effects were indicated in unvaccinated males, as we observed a gradual decrease in AGW rates from the 1993 male birth cohort and onwards.PMID:37516572 | DOI:10.1016/j.vaccine.2023.07.031
Source: Vaccine - July 29, 2023 Category: Allergy & Immunology Authors: St åle Nygård Mari Nyg ård Madleen Orumaa Bo T Hansen Source Type: research
PD-1/PD-L1 blockade restores tumor-induced COVID-19 vaccine bluntness
In this study, using preclinical models, we found that the tumor-suppressed COVID-19 vaccine responses are largely reverted in the setting of PD-1/PD-L1 ICB therapy. We also identified that the PD-1/PD-L1 blockade-directed restoration of COVID-19 vaccine effectiveness is irrelevant to anti-tumor therapeutic outcomes. Mechanistically, the restored COVID-19 vaccine effectiveness is entwined with the PD-1/PD-L1 blockade-driven preponderance of follicular helper T cell and germinal center responses during ongoing malignancy. Thus, our findings indicate that PD-1/PD-L1 blockade will greatly normalize the responses of cancer pat...
Source: Vaccine - July 3, 2023 Category: Allergy & Immunology Authors: Xiangyu Chen Yao Lin Shuai Yue Yang Yang Xiaofan Yang Junjian He Leiqiong Gao Zhirong Li Li Hu Jianfang Tang Yifei Wang Qin Tian Yaxing Hao Lifan Xu Qizhao Huang Yingjiao Cao Lilin Ye Source Type: research
Impact, cost-effectiveness, and budget implications of HPV vaccination in Kenya: A modelling study
CONCLUSION: HPV vaccination for girls is highly cost-effective in Kenya. Compared to GARDASIL-4, alternative products could provide similar or greater health benefits at lower net costs. Substantial government funding will be required to reach and sustain coverage targets as Kenya graduates from Gavi support. A single dose strategy is likely to have similar benefits for less cost.PMID:37296015 | DOI:10.1016/j.vaccine.2023.05.019
Source: Vaccine - June 9, 2023 Category: Allergy & Immunology Authors: Valerian Mwenda Rose Jalang'o Christine Miano Joan-Paula Bor Mary Nyangasi Lucy Mecca Vincent Were Edward Kariithi Clint Pecenka Anne Schuind Kaja Abbas Andrew Clark Source Type: research
Cross-neutralizing protection of vaginal and oral mucosa from HPV challenge by vaccination in a mouse model
Vaccine. 2023 Jun 1:S0264-410X(23)00618-7. doi: 10.1016/j.vaccine.2023.05.057. Online ahead of print.ABSTRACTThe species and tissue specificities of HPV (human papillomavirus) for human infection and disease complicates the process of prophylactic vaccine development in animal models. HPV pseudoviruses (PsV) that carry only a reporter plasmid have been utilized in vivo to demonstrate cell internalization in mouse mucosal epithelium. The current study sought to expand the application of this HPV PsV challenge model with both oral and vaginal inoculation and to demonstrate its utility for testing vaccine-mediated dual-site i...
Source: Vaccine - June 3, 2023 Category: Allergy & Immunology Authors: Chelsea Sanders Rebecca L Matthews Sayyed Hamid Zarkesh Esfahani Nazneen Khan Nimit L Patel Joseph D Kalen Reinhard Kirnbauer Richard B Roden Simone Difilippantonio Ligia A Pinto Robert H Shoemaker Jason D Marshall Source Type: research
Influences of sociodemographic characteristics and parental HPV vaccination hesitancy on HPV vaccination coverage in five US states
CONCLUSIONS: Adolescent HPV vaccination coverage remains low in our targeted states. Children's age, sex, and parental vaccine hesitancy were significantly associated with likelihood of HPV vaccination. These findings offer the opportunity for targeted interventions among parents in regions with low vaccine uptake and underscore the importance of developing and implementing strategies to address parental HPV vaccination hesitancy to improve uptake in the US.PMID:37198022 | DOI:10.1016/j.vaccine.2023.04.082
Source: Vaccine - May 17, 2023 Category: Allergy & Immunology Authors: T Shato S Humble A Anandarajah A Barnette H M Brandt J Garbutt L Klesges V S Thompson M I Silver Source Type: research
