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Specialty: Allergy & Immunology
Source: Clinical Immunology
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Total 1593 results found since Jan 2013.
The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Sep 18:109778. doi: 10.1016/j.clim.2023.109778. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the dysregulation of B cell subpopulation and function. Recent studies have suggested a potential role of ferroptosis, an iron-dependent form of regulated cell death, in the pathogenesis of SLE. Here, we demonstrate that B-cell ferroptosis occurs both in lupus patients and MRL/lpr mice. Treatment with liproxstatin-1, a potent ferroptosis inhibitor, could reduce autoantibody production, improve renal damage, and alleviate lupus symptoms in vivo. ...
Source: Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Chen Mengmeng Xiang Zhanyan Gao Fan Lvu Zhan Sun Yilun Wang Xiangguang Shi Jinhua Xu Jie Wang Jun Liang Source Type: research
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review
CONCLUSION: APS-associated DAH is associated with high morbidity and mortality, particularly when presenting with triple positivity, thrombocytopenia, valvular involvement, and CAPS.PMID:37722463 | DOI:10.1016/j.clim.2023.109775
Source: Clinical Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Gabriel Figueroa-Parra Jose A Meade-Aguilar Hannah E Langenfeld Mariana Gonz ález-Treviño Mehmet Hocaoglu Andrew C Hanson Larry J Prokop M Hassan Murad Rodrigo Cartin-Ceba Ulrich Specks Vikas Majithia Cynthia S Crowson Al í Duarte-García Source Type: research
DNA methylation profiling and integrative multi-omics analysis of skin samples reveal important contribution of epigenetics and immune response in the pathogenesis of acne vulgaris
This study supports the significant contribution of epigenetics to the pathogenesis of acne vulgaris and may provide new ideas for the molecular mechanisms of and potential therapeutic strategies for acne vulgaris.PMID:37717673 | DOI:10.1016/j.clim.2023.109773
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Lin Liu Yuzhou Xue Jiayi Chen Yuxin Li Tingqiao Chen Xingyu Pan Judan Zhong Xinyi Shao Yangmei Chen Jin Chen Source Type: research
MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway
Clin Immunol. 2023 Sep 15:109770. doi: 10.1016/j.clim.2023.109770. Online ahead of print.ABSTRACTThe combination of antiangiogenic agents and immune checkpoint inhibitors is more efficient than monotherapy in the management of hepatocellular carcinoma (HCC). Lenvatinib plus anti-PD1 antibodies have become the mainstay in HCC treatment. However, more than half the patients with HCC are non-responsive, and the mechanisms underlying drug resistance are unknown. To address this issue, we performed single-cell sequencing on samples from six HCC patients, aiming to explore cellular signals and molecular pathways related to the e...
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Cheng Zhou Bao-Ye Sun Pei-Yun Zhou Zhang-Fu Yang Zhu-Tao Wang Gao Liu Wei Gan Zheng Wang Jian Zhou Jia Fan Yong Yi Ning Ren Shuang-Jian Qiu Source Type: research
DNA methylation profiling and integrative multi-omics analysis of skin samples reveal important contribution of epigenetics and immune response in the pathogenesis of acne vulgaris
This study supports the significant contribution of epigenetics to the pathogenesis of acne vulgaris and may provide new ideas for the molecular mechanisms of and potential therapeutic strategies for acne vulgaris.PMID:37717673 | DOI:10.1016/j.clim.2023.109773
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Lin Liu Yuzhou Xue Jiayi Chen Yuxin Li Tingqiao Chen Xingyu Pan Judan Zhong Xinyi Shao Yangmei Chen Jin Chen Source Type: research
MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway
Clin Immunol. 2023 Sep 15:109770. doi: 10.1016/j.clim.2023.109770. Online ahead of print.ABSTRACTThe combination of antiangiogenic agents and immune checkpoint inhibitors is more efficient than monotherapy in the management of hepatocellular carcinoma (HCC). Lenvatinib plus anti-PD1 antibodies have become the mainstay in HCC treatment. However, more than half the patients with HCC are non-responsive, and the mechanisms underlying drug resistance are unknown. To address this issue, we performed single-cell sequencing on samples from six HCC patients, aiming to explore cellular signals and molecular pathways related to the e...
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Cheng Zhou Bao-Ye Sun Pei-Yun Zhou Zhang-Fu Yang Zhu-Tao Wang Gao Liu Wei Gan Zheng Wang Jian Zhou Jia Fan Yong Yi Ning Ren Shuang-Jian Qiu Source Type: research
Temozolomide-based sonodynamic therapy induces immunogenic cell death in glioma
CONCLUSIONS: TMZ-based SDT was capable of triggering ICD in glioma. The discovery of TMZ as a sonosensitizer have shown great promise in the treatment of GBM.PMID:37716612 | DOI:10.1016/j.clim.2023.109772
Source: Clinical Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Yan Zhou Jiji Jiao Rongyan Yang Binli Wen Qiaoli Wu Lixia Xu Xiaoguang Tong Hua Yan Source Type: research
Architecture of skin inflammation in psoriasis revealed by spatial transcriptomics
Clin Immunol. 2023 Sep 12:109771. doi: 10.1016/j.clim.2023.109771. Online ahead of print.ABSTRACTPsoriasis is a chronic inflammatory skin disease, thought to be predominantly mediated by TH17 cells. Significance of other inflammatory pathways and the innate immune system is not well understood and the spatial heterogeneity of inflammation in the skin has largely been overlooked. Our aim was to create a comprehensive map of skin inflammation in psoriasis, exploring the tissue patterning of inflammation. In situ whole transcriptome sequencing (spatial sequencing) was performed on lesional psoriatic skin in four patients with...
Source: Clinical Immunology - September 14, 2023 Category: Allergy & Immunology Authors: Robert Gniadecki Mohammed Osman Dylan Hennesey Sandra O'Keefe Simon Francis Thomsen Aishwarya Iyer Source Type: research
Infections due to Salmonella sp. in children with chronic granulomatous disease: Our experience from North India
Clin Immunol. 2023 Sep 11:109769. doi: 10.1016/j.clim.2023.109769. Online ahead of print.ABSTRACTInfections with non-typhoidal Salmonella sp. have been documented in children with chronic granulomatous disease (CGD), but the prevalence of salmonella infection in children with CGD in underdeveloped countries is unknown. We assessed the clinical profiles of CGD patients diagnosed at our tertiary care centre in north India and had Salmonella sp.infections. We found three patients with Salmonella sp. bloodstream infections (2-proven, 1-probable) among the 99 CGD patients. After receiving cotrimoxazole prophylaxis following a C...
Source: Clinical Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Suprit Basu Pandiarajan Vignesh K Prithiviraj Pallavi L Nadig Aravind Sekar Amit Rawat Source Type: research
Biallelic MTHFD1 variants presenting as severe combined immunodeficiency
Clin Immunol. 2023 Sep 8:109768. doi: 10.1016/j.clim.2023.109768. Online ahead of print.NO ABSTRACTPMID:37690615 | DOI:10.1016/j.clim.2023.109768
Source: Clinical Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Ashley Sang Eun Lee Karina Rotella Amanda Agyemang Hsi-En Ho Kimihiko Oishi Charlotte Cunningham-Rundles Source Type: research
