Filtered By:
Source: Clinical Rheumatology

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 34 results found since Jan 2013.

The risk of ischemic stroke in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis
ConclusionIIMs, especially patients with DM, are associated with an increased risk of ischemic stroke. Appropriate intervention may be taken into account for patients with IIM, especially when accompanied by other traditional risk factors of ischemic stroke.Key Points•This study evaluated the risk of ischemic stroke in patients with IIMs.•Generally, IIMs are associated with an increased risk of ischemic stroke.•Patients with DM had a 49% excess risk of ischemic stroke than controls.•Subgroup analysis showed that Asian patients with IIMs were at increased risk of ischemic stroke, but not Americans.
Source: Clinical Rheumatology - May 1, 2021 Category: Rheumatology Source Type: research

Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China
ConclusionsA close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors.
Source: Clinical Rheumatology - February 7, 2019 Category: Rheumatology Source Type: research

Systemic inflammatory response index as an independent risk factor for ischemic stroke in patients with rheumatoid arthritis: a retrospective study based on propensity score matching
ConclusionSIRI was independently associated with the occurrence of ischemic stroke in patients with RA. Thus, RA patients with elevated SIRI should be closely monitored.Key points•RA patients with IS had fewer traditional risk factors such as hypertension and diabetes, while inflammatory indicators were significantly increased.•The SIRI have drawn attention in recent years as novel non-specific inflammatory markers. However, only a few studies have been conducted to investigate their value in RA.•This study completes the gaps in the research on the relationship between SIRI and the risk of IS occurrence in RA patients.
Source: Clinical Rheumatology - May 9, 2021 Category: Rheumatology Source Type: research

Colchicine may become a new cornerstone therapy for coronary artery disease: a meta ‐analysis of randomized controlled trials
AbstractPurposeColchicine is an ancient anti-inflammatory drug. In recent years, an increasing number of studies have shown that colchicine improves the prognosis of patients with coronary artery disease (CAD), while other studies have reported the opposite. The aim of this study was to evaluate the relative efficacy and safety of colchicine in treating CAD.MethodsPubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were searched from inception to 20 October 2020 for randomized controlled trials (RCTs) comparing colchicine and placebo in patients with CAD. The primary outcomes were the primary composite outcomes of...
Source: Clinical Rheumatology - February 9, 2022 Category: Rheumatology Source Type: research

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Subcutaneous nodules are associated with cardiovascular events in patients with rheumatoid arthritis: results from a large US registry
The objective of this study is to examine the possibility of a relationship between subcutaneous nodules and “first ever” cardiovascular disease event, i.e., myocardial infarction (MI), stroke, or cardiovascular death in a large registry-cohort of patients with RA. Patient information was collected from the CORRONA registry from October 2001 to September 2011. A total of 26,042 patients with RA were studied for the presence or absence of subcutaneous nodules. Cox proportional hazards regression models were constructed to estimate the hazard ratios (HR) for CVD events in relation to subcutaneous nodules at baseline. Thr...
Source: Clinical Rheumatology - August 4, 2015 Category: Rheumatology Source Type: research

Risk of bleeding events among patients with systemic sclerosis and the general population in the UK: a large population-based cohort study
ConclusionOur results are consistent with a moderately increased risk of bleeding in SSc patients. Further evidence from large SSc patient cohorts is needed to confirm this finding.Key Points•The risk of experiencing a major bleed may be higher among patients with SSc than the general population.•Further large and well-designed studies are needed to corroborate our findings.
Source: Clinical Rheumatology - May 13, 2019 Category: Rheumatology Source Type: research

Primary angiitis of the central nervous system and reversible cerebral vasoconstriction syndrome: analysis of the National Inpatient Sample
ConclusionsWe performed an analysis of the NIS to better understand RCVS and PACNS hospitalizations. Severe neurologic events including CVA and SAH were elevated in both, but SAH and related hemiplegia/hemiparesis were extremely common among RCVS hospitalizations. In-hospital mortality was elevated in PACNS but not RCVS. This information can be used to help clinicians better understand, distinguish, and diagnose these conditions.Key Points•Despite clear description of RCVS and PACNS in the medical literature, there remains a scarcity of national population-based studies comparing these two entities against the general ad...
Source: Clinical Rheumatology - April 12, 2022 Category: Rheumatology Source Type: research

Cerebrovascular involvement in systemic childhood vasculitides
AbstractPediatric vasculitides sometimes involve central nervous system (CNS). The manifestations are diverse, ranging from headache, seizures, vertigo, ataxia, behavioral changes, neuropsychiatric symptoms, consciousness disorders, and even cerebrovascular (CV) accidents that may lead to irreversible impairment and even death. Stroke, on the other hand despite the great progress in prevention and treatment, is still one of the leading causes of morbidity and mortality in the general population. The aim of this article was to summarize CNS manifestations and CV issues observed in primary pediatric vasculitides and the curr...
Source: Clinical Rheumatology - March 8, 2023 Category: Rheumatology Source Type: research

Bilateral scalp necrosis as a rare but devastating complication of giant cell arteritis
We report a case of a man who presented with a 4-week history of bilateral scalp necrosis associated with headache, jaw claudication, temporal artery tenderness, and raised inflammatory markers. He did not have any visual loss. A diagnosis of GCA was made and he was started on high-dose steroids immediately. The scalp lesions did improve and his symptoms resolved without any visual loss but, sadly he died due to severe sepsis. This case report is important as it describes a rare but severe complication of a common large vessel vasculitis seen by both primary care physicians and rheumatologists. Prompt recognition and early...
Source: Clinical Rheumatology - January 1, 2015 Category: Rheumatology Source Type: research

Procoagulant microparticles are increased in patients with Behçet’s disease but do not define a specific subset of clinical manifestations
Abstract Microparticles (MP) are considered a key component in the haemostatic response. Beyond their in vitro procoagulant properties, a number of pieces of evidence points to procoagulant MP as efficient effectors in the haemostatic response and as pathogenic markers of thrombotic disorders and vascular damage. The aim of the present study was to analyze the procoagulant activity of MP and its correlation with clinical manifestations focusing on vascular involvement in patients with Behçet’s disease (BD). We analyzed 55 BD patients in inactive phase of the disease (26 men; mean age, 35 ± 15 years) of wh...
Source: Clinical Rheumatology - February 26, 2015 Category: Rheumatology Source Type: research

The impact of inflammatory rheumatic diseases on the presentation, severity, and outcome of acute coronary syndrome
Abstract Patients with inflammatory rheumatic diseases (IRD) have a high burden of cardiovascular disease (CVD), leading to increased mortality and morbidity. However, it is not clear whether increased CVD mortality in IRD is due to a higher incidence or worse outcome of cardiovascular events (higher case fatality). In this observational case–control study, we assessed the outcome of acute coronary syndrome (ACS) in patients with IRDs compared to matched controls without IRD, using data from the Acute Coronary Syndrome Israeli Survey (ACSIS), a large, national, real-life registry detailing the extent, severity,...
Source: Clinical Rheumatology - January 1, 2016 Category: Rheumatology Source Type: research