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Role of FAK signaling in chagasic cardiac hypertrophy.
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the implication of focal adhesion kinase (FAK) signaling pathway in triggering hypertrophic phenotype during acute and chronic T. cruzi infection. C57BL/6 mice infected with T. cruzi (Brazil strain) were evaluated for electrocardiographic (ECG) changes, plasma levels of...
Source: Braz J Infect Dis - September 11, 2020 Category: Infectious Diseases Authors: Tucci AR, Oliveira FOR, Lechuga GC, Oliveira GM, Eleuterio AC, Mesquita LB, Farani PSG, Britto C, Moreira OC, Pereira MCS Tags: Braz J Infect Dis Source Type: research