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Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review
Rev Inst Med Trop Sao Paulo. 2022 Mar 11;64:e23. doi: 10.1590/S1678-9946202264023. eCollection 2022.ABSTRACTDespite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over t...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 16, 2022 Category: Tropical Medicine Authors: K éssia Caroline Souza Alves Jander Matos Guimar ães Maria Edilene Martins de Almeida Lu ís André Morais Mariúba Source Type: research

Circumsporozoite Surface Protein-based malaria vaccines: a review.
Abstract Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradicatio...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 5, 2021 Category: Tropical Medicine Authors: Almeida MEM, Vasconcelos MGS, Tarragô AM, Mariúba LAM Tags: Rev Inst Med Trop Sao Paulo Source Type: research