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Source: The Journal of Thoracic and Cardiovascular Surgery
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Total 276 results found since Jan 2013.
Take me to your bleeder: Recombinant factor VIIa —finding its way in cardiac surgery
In this issue of the Journal, Dr Zindovic and colleagues1 examined whether data from the Nordic Consortium for Acute Type A Aortic Dissection database indicated that use of recombinant factor VIIa (rFVIIa) was associated with mortality, stroke, or renal replacement therapy after acute type A aortic dissection (ATAAD) surgical repair. Bleeding in ATAAD repair is a concern to all surgeons performing such operations. Any adjunct to attenuate bleeding is appreciated, and in ATAAD, rFVIIa has been suggested to do so.
Source: The Journal of Thoracic and Cardiovascular Surgery - September 4, 2017 Category: Cardiovascular & Thoracic Surgery Authors: John Bozinovski Tags: Editorial commentary Source Type: research
Straight deep hypothermic circulatory arrest for aortic arch surgery: Going the way of the dinosaurs?
In this issue of the Journal, Damberg and colleagues1 report their experience with straight deep hypothermic circulatory arrest (DHCA) as the sole means of brain protection during operations on the aortic arch in 613 consecutive patients, focusing on late outcomes.1 The independent variables associated with increased 1-year mortality were acute type A aortic dissection, reoperative status, and the presence of descending thoracic aortic pathology. The independent variables associated with increased mortality beyond 1 year were increased age, postoperative complications (stroke, dialysis, pulmonary complications), and post...
Source: The Journal of Thoracic and Cardiovascular Surgery - August 28, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Nicholas T. Kouchoukos Tags: Editorial commentary Source Type: research
Favorable Late Survival After Aortic Surgery Under Straight Deep Hypothermic Circulatory Arrest
Surgical and cerebral protection strategies in aortic arch surgery are still under debate. Perioperative results using deep hypothermic circulatory arrest (DHCA) have shown favorable short-term mortality and stroke rates. The present study focuses on late survival.
Source: The Journal of Thoracic and Cardiovascular Surgery - August 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Anneke Damberg, Davide Carino, Paris Charilaou, Sven Peterss, Maryann Tranquilli, Bulat A. Ziganshin, John A. Rizzo, John A. Elefteriades Source Type: research
Timing of surgery in infective endocarditis with cerebral complications: Time to think outside the nonexistent box
In the April 2017 issue of the Journal, Murai and coworkers1 report on the effect of the interaction between stroke severity and timing of surgery on clinical outcomes in patients with active infective endocarditis (IE) and cerebral complications with moderate neurologic deficits. Their retrospective study cohort consisted of 170 consecutive patients from a single institution during a 24-year period starting in 1990. The National Institutes of Health Stroke Scale was used to evaluate the severity of stroke.
Source: The Journal of Thoracic and Cardiovascular Surgery - August 12, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Maroun Yammine, Tsuyoshi Kaneko, Sary Aranki Tags: Editorial commentary Source Type: research
Discussion
Dr W. Szeto (Philadelphia, Pa). Congratulations, Dr Ma, on a very well-presented talk. I want to congratulate you on such extraordinary and impressive results. This is obviously a difficult set of patients. Less than 1% stroke rate, 6.6% mortality, that is impressive. Just a few questions.
Source: The Journal of Thoracic and Cardiovascular Surgery - August 7, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research
Creating a lung adenocarcinoma canvas, one brush stroke at a time
In their carefully characterized large cohort of resected adenocarcinomas reported in this issue of the Journal, Takamochi and colleagues1 demonstrate that epidermal growth factor receptor gene (EGFR) mutations are associated with better prognoses and that subtypes of mutations are not. With nearly 1000 patients analyzed, the study serves as an important guidepost as we navigate treatment courses, weighing the relative importance of each genetic change —particularly driver mutations in lung cancer, both adenocarcinomas and squamous cell carcinomas.
Source: The Journal of Thoracic and Cardiovascular Surgery - July 22, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Sai Yendamuri Tags: Editorial commentary Source Type: research
Creating a Lung Adenocarcinoma Canvas One Brush Stroke at a Time
Source: The Journal of Thoracic and Cardiovascular Surgery - July 22, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Sai Yendamuri Source Type: research
The importance of capillary density –stroke work mismatch for right ventricular adaptation to chronic pressure overload
Mechanisms of right ventricular (RV) adaptation to chronic pressure overload are not well understood. We hypothesized that a lower capillary density (CD) to stroke work ratio would be associated with more fibrosis and RV maladaptive remodeling.
Source: The Journal of Thoracic and Cardiovascular Surgery - June 14, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Pierre-Emmanuel Noly, Fran çois Haddad, Jennifer Arthur-Ataam, Nathaniel Langer, Peter Dorfmüller, Fanny Loisel, Julien Guihaire, Benoit Decante, Lilia Lamrani, Elie Fadel, Olaf Mercier Tags: Basic science Source Type: research
The importance of Capillary Density/Stroke Work Mismatch for Right Ventricular adaptation to Chronic Pressure Overload
Mismatch angiogenesis/workload was associated with greater degree of RV dysfunction in animal models. The CD/SW ratio could be a promising index to assess right ventricular adaptation to pressure overload state.
Source: The Journal of Thoracic and Cardiovascular Surgery - June 14, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Pierre-Emmanuel Noly, Fran çois Haddad, Jennifer Arthur Ataam, Nathaniel Langer, Peter Dorfmüller, Fanny Loisel, Julien Guihaire, Benoit Decante, Lilia Lamrani, Elie Fadel, Olaf Mercier Source Type: research
Cerebral protection for transcatheter aortic valve implantation: A no brainer?
Stroke is one of most devastating and dreaded complications of cardiothoracic procedures, associated with dramatically increased mortality, morbidity, and costs.1,2 Recent years have seen heightened awareness of the prevalence and impact of neurologic complications of surgery. Simultaneously, transcatheter aortic valve implantation (TAVI) has emerged as a major advance in the management of patients with calcific valvular disease, a condition that is becoming increasingly common owing to the aging of the population.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 25, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Steven R. Mess é, Karen L. Furie Tags: Feature expert opinion Source Type: research
A how-to-do-it message from the strategic surgical command center
Recently, a manuscript arrived on my desk from an accomplished cardiothoracic surgeon, Michael Halkos, from the Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Ga, with a host of coinvestigators. Their Perspective statement read “Aortic clamping during CABG surgery is associated with cerebral atheroembolism, which is likely responsible for increased periprocedural stroke risk in patients undergoing CABG. The findings of this study support the use of traditional clamping methods during on- or off-pump CABG for patients wit h low-grade aortic disease.” The Emory group has been at the for...
Source: The Journal of Thoracic and Cardiovascular Surgery - May 24, 2017 Category: Cardiovascular & Thoracic Surgery Authors: John W. Hammon Tags: Editorial commentary Source Type: research
Preclinical efficacy and safety of KCNH2-G628S gene therapy for post-operative atrial fibrillation
We examined preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Source Type: research
Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation
We examined the preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Tags: Evolving technology Source Type: research
Reducing stroke during cardiac surgery: Back flushing and manipulation is for plumbers, not surgeons
Source: The Journal of Thoracic and Cardiovascular Surgery - April 3, 2017 Category: Cardiovascular & Thoracic Surgery Authors: William M. DeCampli Source Type: research
