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Source: Clinical and Experimental Pharmacology and Physiology

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Total 57 results found since Jan 2013.

Rosavin protects the blood-brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway
In conclusion, rosavin protects the BBB against I/R injury possibly by regulating the MAPK pathway. The above results provide a rationale for further exploration of rosavin as a therapeutic candidate for cerebral I/R injury.PMID:37254848 | DOI:10.1111/1440-1681.13781
Source: Clinical and Experimental Pharmacology and Physiology - May 31, 2023 Category: Drugs & Pharmacology Authors: Hongyun Zou Lei Li Zhilai Yang Lili Tang Chunhui Wang Source Type: research

Combination of SVI/S' and diagnostic scores for heart failure with preserved ejection fraction
This study aimed to compare the three approaches in patients with suspected HFpEF. Patients referred to right heart catheterization for suspected HFpEF were classified into low-, intermediate- and high-likelihood groups according to H2 FPEF or HFA-PEFF scores. A diagnosis of HFpEF was confirmed by pulmonary capillary wedge pressure (PCWP) of ≥15 mm Hg according to the guidelines. In result, a total of 128 patients were included. Of these, 71 patients with PCWP ≥15 mm Hg and 57 patients with PCWP <15 mm Hg. Moderate correlations were observed between H2 FPEF score, HFA-PEFF score, SVI/S' and PCWP. The area under curv...
Source: Clinical and Experimental Pharmacology and Physiology - May 19, 2023 Category: Drugs & Pharmacology Authors: Guanyu Mu Weiding Wang Changle Liu Juan Xie Hao Zhang Xiaowei Zhang Jingjin Che Gary Tse Tong Liu Guangping Li Huaying Fu Kangyin Chen Source Type: research