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Use of CHA2DS2-VASc score to predict the risk of ischemic stroke and mortality in patients who underwent coronary artery bypass grafting surgery: a retrospective cohort study
CONCLUSIONS: Ischemic stroke was associated with a higher mortality risk after CABG. Higher CHA2DS2-VASc scores were associated with higher ischemic stroke risk. POAF did not significantly affect the relationship between CHA2DS2-VASc scores and ischemic stroke. CHA2DS2-VASc score can be used to predict ischemic stroke and mortality following CABG.PMID:36734704 | DOI:10.26355/eurrev_202301_31062
Source: Pharmacological Reviews - February 3, 2023 Category: Drugs & Pharmacology Authors: B D üzel Source Type: research

Comparison of aspirin and P2Y12 inhibitors for secondary prevention of ischaemic stroke: A systematic review and meta-analysis
CONCLUSION: This meta-analysis suggests that P2Y12 inhibitors are more effective than aspirin in preventing recurrent ischaemic stroke among ischaemic stroke patients despite the absence of any effect on a new ischaemic or haemorrhagic stroke, a new clinical vascular event, all-cause death, and major or minor bleeding events.PMID:35619249 | DOI:10.2174/2772432817666220526162144
Source: Pharmacological Reviews - May 27, 2022 Category: Drugs & Pharmacology Authors: Kaili Zhang Yongle Wang Tingting Liu Xiaoyuan Niu Source Type: research

Stroke prevention: knowledge of the general population in Riyadh Region, Saudi Arabia
CONCLUSIONS: Stroke knowledge among the population of Saudi Arabia is inadequate. The stroke knowledge is related to age and occupation.PMID:34533817 | DOI:10.26355/eurrev_202109_26649
Source: Pharmacological Reviews - September 17, 2021 Category: Drugs & Pharmacology Authors: S M Abdalla E Y Mohamed B A Almehmadi M A Alanazi H M Elsabagh Source Type: research

Correlation between Vitamin D, homocysteine and brain-derived neurotrophic factor levels in patients with ischemic stroke
CONCLUSIONS: Vitamin D supplementation was used as a therapeutic agent in patients with acute ischemic stroke that affects homocysteine and BDNF levels. In this study, it was demonstrated for the first time that there is a correlation between serum vitamin D levels and BDNF levels in patients who have experienced a stroke.PMID:36394751 | DOI:10.26355/eurrev_202211_30154
Source: Pharmacological Reviews - November 17, 2022 Category: Drugs & Pharmacology Authors: U F Yurekli Z Tunc Source Type: research

Oncotic Cell Death in Stroke.
Abstract Oncotic cell death or oncosis represents a major mechanism of cell death in ischaemic stroke, occurring in many central nervous system (CNS) cell types including neurons, glia and vascular endothelial cells. In stroke, energy depletion causes ionic pump failure and disrupts ionic homeostasis. Imbalance between the influx of Na+ and Cl- ions and the efflux of K+ ions through various channel proteins and transporters creates a transmembrane osmotic gradient, with ensuing movement of water into the cells, resulting in cell swelling and oncosis. Oncosis is a key mediator of cerebral oedema in ischaemic stroke...
Source: Pharmacological Reviews - December 5, 2018 Category: Drugs & Pharmacology Authors: Loh KY, Wang Z, Liao P Tags: Rev Physiol Biochem Pharmacol Source Type: research

Prevalence of stroke and myocardial infarction among patients with deteriorated GFR
CONCLUSIONS: Deteriorated GFR <60 mL/min is significantly associated with stroke and myocardial infarction. Stroke and MI are more prevalent among men than women. Stroke and MI are more prevalent in middle-aged adults and older individuals.PMID:36111945 | DOI:10.26355/eurrev_202209_29649
Source: Pharmacological Reviews - September 16, 2022 Category: Drugs & Pharmacology Authors: S H Alharbi Source Type: research

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