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WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats.
Conclusion:Tau-1 is expressed in NG2(+) cells following permanent focal cerebral ischemic injury. Treatment with WIN55,212-2 reduces the number of tau-1(+)/NG2(+) cells and promotes NG2(+) cell proliferation in the stroke penumbra, which are mediated partially via CB1 and may contribute to its neuroprotective effects. PMID: 23202804 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J, Song S, Zhang LY, Liao H Tags: Acta Pharmacol Sin Source Type: research

What can we learn about stroke from retinal ischemia models?
Abstract Retinal ischemia is a very useful model to study the impact of various cell death pathways, such as apoptosis and necrosis, in the ischemic retina. However, it is important to note that the retina is formed as an outpouching of the diencephalon and is part of the central nervous system. As such, the cell death pathways initiated in response to ischemic damage in the retina reflect those found in other areas of the central nervous system undergoing similar trauma. The retina is also more accessible than other areas of the central nervous system, thus making it a simpler model to work with and study. By uti...
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: D'Onofrio PM, Koeberle PD Tags: Acta Pharmacol Sin Source Type: research

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