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Source: Acta Pharmacologica Sinica
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Total 122 results found since Jan 2013.
Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window
Acta Pharmacol Sin. 2022 May 2. doi: 10.1038/s41401-022-00913-7. Online ahead of print.ABSTRACTProgressive ischemic stroke (PIS) is featured by progressive neurological dysfunction after ischemia. Ischemia-evoked neuroinflammation is implicated in the progressive brain injury after cerebral ischemia, while Caspase-1, an active component of inflammasome, exaggerates ischemic brain injury. Current Caspase-1 inhibitors are inadequate in safety and druggability. Here, we investigated the efficacy of CZL80, a novel Caspase-1 inhibitor, in mice with PIS. Mice and Caspase-1-/- mice were subjected to photothrombotic (PT)-induced c...
Source: Acta Pharmacologica Sinica - May 2, 2022 Category: Drugs & Pharmacology Authors: Ling Pan Wei-Dong Tang Ke Wang Qi-Feng Fang Meng-Ru Liu Zhan-Xun Wu Yi Wang Sun-Liang Cui Gang Hu Ting-Jun Hou Wei-Wei Hu Zhong Chen Xiang-Nan Zhang Source Type: research
Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation
Acta Pharmacol Sin. 2022 Mar 30. doi: 10.1038/s41401-022-00892-9. Online ahead of print.ABSTRACTRivaroxaban, a direct factor Xa inhibitor, is widely used for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). The aim of this study was to conduct a population pharmacokinetic-pharmacodynamic (PK-PD) analysis of rivaroxaban in Chinese patients with NVAF to assess ethnic differences and provide model-based precision dosing. A total of 256 rivaroxaban plasma concentrations and 244 prothrombin time (PT) measurements were obtained from 195 Chinese NVAF patients from a prospective clinical trial. The popul...
Source: Acta Pharmacologica Sinica - March 31, 2022 Category: Drugs & Pharmacology Authors: Xiao-Qin Liu Yu-Fei Zhang Hong-Yan Ding Ming-Ming Yan Zheng Jiao Ming-Kang Zhong Chun-Lai Ma Source Type: research
Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3 β/β-catenin signaling pathway
Acta Pharmacol Sin. 2022 Feb 25. doi: 10.1038/s41401-021-00844-9. Online ahead of print.ABSTRACTStroke is the major cause of death and disability worldwide. Most stroke patients who survive in the acute phase of ischemia display various extents of neurological deficits. In order to improve the prognosis of ischemic stroke, promoting endogenous neurogenesis has attracted great attention. Salvianolic acid A (SAA) has shown neuroprotective effects against ischemic diseases. In the present study, we investigated the neurogenesis effects of SAA in ischemic stroke rats, and explored the underlying mechanisms. An autologous throm...
Source: Acta Pharmacologica Sinica - February 26, 2022 Category: Drugs & Pharmacology Authors: Sen Zhang De-Wen Kong Guo-Dong Ma Cheng-di Liu Yu-Jiao Yang Shan Liu Nan Jiang Zi-Rong Pan Wen Zhang Ling-Lei Kong Guan-Hua Du Source Type: research
Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?
Acta Pharmacol Sin. 2022 Jan 11. doi: 10.1038/s41401-021-00838-7. Online ahead of print.ABSTRACTThe nicotinamide adenine dinucleotide (NAD+/NADH) and nicotinamide adenine dinucleotide phosphate (NADP+/NADPH) redox couples function as cofactors or/and substrates for numerous enzymes to retain cellular redox balance and energy metabolism. Thus, maintaining cellular NADH and NADPH balance is critical for sustaining cellular homeostasis. The sources of NADPH generation might determine its biological effects. Newly-recognized biosynthetic enzymes and genetically encoded biosensors help us better understand how cells maintain bi...
Source: Acta Pharmacologica Sinica - January 12, 2022 Category: Drugs & Pharmacology Authors: Nirmala Koju Zheng-Hong Qin Rui Sheng Source Type: research
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling
In conclusion, catalpol protects NVU in ischemic region via activation of PI3K/AKT signaling and increased VEGF production; VEGF further enhances PI3K/AKT and MEK1/2/ERK1/2 signaling, which may trigger a partly feed-forward loop to protect NVU from ischemic stroke.PMID:34795412 | DOI:10.1038/s41401-021-00803-4
Source: Acta Pharmacologica Sinica - November 19, 2021 Category: Drugs & Pharmacology Authors: Hong-Jin Wang Hai-Feng Ran Yue Yin Xiao-Gang Xu Bao-Xiang Jiang Shi-Qi Yu Yi-Jin Chen Hui-Jing Ren Shan Feng Ji-Fen Zhang Yi Chen Qiang Xue Xiao-Yu Xu Source Type: research
Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction
In this study we investigated the impacts of iptakalim on pericytes contraction in stroke. Mice were subjected to cerebral artery occlusion (MCAO), then administered iptakalim (10 mg/kg, ip). We showed that iptakalim administration significantly promoted recovery of cerebral blood flow after cerebral ischemia and reperfusion. Furthermore, we found that iptakalim significantly inhibited pericytes contraction, decreased the number of obstructed capillaries, and improved cerebral microcirculation. Using a collagen gel contraction assay, we demonstrated that cultured pericytes subjected to oxygen-glucose deprivation (OGD) cons...
Source: Acta Pharmacologica Sinica - October 26, 2021 Category: Drugs & Pharmacology Authors: Ruo-Bing Guo Yin-Feng Dong Zhi Yin Zhen-Yu Cai Jin Yang Juan Ji Yu-Qin Sun Xin-Xin Huang Teng-Fei Xue Hong Cheng Xi-Qiao Zhou Xiu-Lan Sun Source Type: research
