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Source: Acta Pharmacologica Sinica
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Total 122 results found since Jan 2013.
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism
In this study, we investigated the molecular mechanisms underlying RIPK1-mediated astrocyte injury in vitro and in vivo. Primary cultured astrocytes were transfected with lentiviruses and then subjected to oxygen and glucose deprivation (OGD). In a rat model of permanent middle cerebral artery occlusion (pMCAO), lentiviruses carrying shRNA targeting RIPK1 or shRNA targeting heat shock protein 70.1B (Hsp70.1B) were injected into the lateral ventricles 5 days before pMCAO was established. We showed that RIPK1 knockdown protected against OGD-induced astrocyte damage, blocked the OGD-mediated increase in lysosomal membrane per...
Source: Acta Pharmacologica Sinica - April 13, 2023 Category: Drugs & Pharmacology Authors: Hua-Ping Du Yi Guo Yong-Ming Zhu De-Fei Gao Bo Lin Yuan Liu Yuan Xu Ali Said Taous Khan Li-Jun Liu Jian-Jun Zhu Yong Ni Hui-Ling Zhang Source Type: research
