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Source: Acta Pharmacologica Sinica

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Total 122 results found since Jan 2013.

Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling
In conclusion, catalpol protects NVU in ischemic region via activation of PI3K/AKT signaling and increased VEGF production; VEGF further enhances PI3K/AKT and MEK1/2/ERK1/2 signaling, which may trigger a partly feed-forward loop to protect NVU from ischemic stroke.PMID:34795412 | DOI:10.1038/s41401-021-00803-4
Source: Acta Pharmacologica Sinica - November 19, 2021 Category: Drugs & Pharmacology Authors: Hong-Jin Wang Hai-Feng Ran Yue Yin Xiao-Gang Xu Bao-Xiang Jiang Shi-Qi Yu Yi-Jin Chen Hui-Jing Ren Shan Feng Ji-Fen Zhang Yi Chen Qiang Xue Xiao-Yu Xu Source Type: research

Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery.
CONCLUSION: Cx43 can stabilize astrocytes and facilitate the resistance to the deleterious effects of a stroke-like milieu and promote neuronal recovery. PMID: 26095039 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - June 22, 2015 Category: Drugs & Pharmacology Authors: Wu LY, Yu XL, Feng LY Tags: Acta Pharmacol Sin Source Type: research

Brain protection against ischemic stroke using choline as a new molecular bypass treatment.
CONCLUSION: Choline effectively attenuates brain ischemic injury in pMCAO rats, possibly by facilitating pial arteriogenesis and cerebral-cortical capillary angiogenesis via upregulating α7 nAChR levels and inducing the expression of HIF-1α and VEGF. PMID: 26567726 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - November 16, 2015 Category: Drugs & Pharmacology Authors: Jin X, Wang RH, Wang H, Long CL, Wang H Tags: Acta Pharmacol Sin Source Type: research

Regulation of microglial activation in stroke.
Abstract When ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events, including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis that result in a profound brain injury. The inflammatory response contributes to secondary neuronal damage, which exerts a substantial impact on both acute ischemic injury and the chronic recovery of the brain function. Microglia are the resident immune cells in the brain that constantly monitor brain microenvironment under normal conditions. Once ischemia occurs, microglia are activated to produce both detrimental and neuroprote...
Source: Acta Pharmacologica Sinica - March 5, 2017 Category: Drugs & Pharmacology Authors: Zhao SC, Ma LS, Chu ZH, Xu H, Wu WQ, Liu F Tags: Acta Pharmacol Sin Source Type: research

The role of KATP channels in cerebral ischemic stroke and diabetes.
Abstract ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain. KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple cellular metabolic state (ATP/ADP ratio) to electrical activity of the cell membrane. KATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone. Under pathophysiological conditions, KATP channels play cytoprotect...
Source: Acta Pharmacologica Sinica - April 19, 2018 Category: Drugs & Pharmacology Authors: Szeto V, Chen NH, Sun HS, Feng ZP Tags: Acta Pharmacol Sin Source Type: research

Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites
In this study, we investigated the effect of pinocembrin on t-PA-induced HT and the potential biomarkers for HT after t-PA thrombolysis, thereby improving the prognosis of stroke. Electrocoagulation-induced thrombotic focal ischemic rats received intravenous infusion of t-PA (10 mg/kg) 6 h after ischemia. Administration of pinocembrin (10 mg/kg, iv) prior t-PA infusion significantly decreased the infarct volume, ameliorated t-PA-induced HT, and protected blood-brain barrier. Metabolomics analysis revealed that 5 differential metabolites in the cerebral cortex and 16 differential metabolites in serum involved in amino acid ...
Source: Acta Pharmacologica Sinica - April 16, 2021 Category: Drugs & Pharmacology Authors: Ling-Lei Kong Li Gao Ke-Xin Wang Nan-Nan Liu Cheng-di Liu Guo-Dong Ma Hai-Guang Yang Xue-Mei Qin Guan-Hua Du Source Type: research

Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF- κB inflammatory signaling pathway.
In conclusion, Xyl-B administered within 2 h after the onset of stroke effectively protects against focal cerebral ischemia; the underlying mechanism may be related to suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway. PMID: 28552908 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 29, 2017 Category: Drugs & Pharmacology Authors: Pan N, Lu LY, Li M, Wang GH, Sun FY, Sun HS, Wen XJ, Cheng JD, Chen JW, Pang JY, Liu J, Guan YY, Zhao LY, Chen WL, Wang GL Tags: Acta Pharmacol Sin Source Type: research

Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice.
In this study we used transcriptome analysis to explore the pure therapeutic mechanisms of BA, JA and their combination (BJ) contributing to phenotype variation and reversal of pathological processes. Mice with middle cerebral artery obstruction were treated with BA, JA, their combination (BJ), or concha margaritifera (CM). Cerebral infarct volume was examined to determine the effect of these compounds on phenotype. Using the hippocampus microarray and ingenuity pathway analysis (IPA) software, we exacted the differentially expressed genes, networks, pathways, and functions in positive-phenotype groups (BA, JA and BJ) by c...
Source: Acta Pharmacologica Sinica - January 18, 2018 Category: Drugs & Pharmacology Authors: Wang PQ, Liu Q, Xu WJ, Yu YN, Zhang YY, Li B, Liu J, Wang Z Tags: Acta Pharmacol Sin Source Type: research

Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients.
In this study we identified and evaluated the contributions of single nucleotide polymorphisms (SNPs) in NR1I2 and cytochrome P450 (CYP) 2C19 alleles to clopidogrel resistance (CR) and long-term clinical outcomes in acute ischemic stroke (IS) patients. A total of 634 patients with acute IS were recruited, who received antiplatelet medication (clopidogrel or aspirin) every day and completed a 1-year follow-up. The selected SNPs were genotyped, and platelet function was measured. Modified Rankin Scale (mRS) scores and main adverse cardiovascular and cerebrovascular events (MACCE) were noted to assess the prognosis. We showed...
Source: Acta Pharmacologica Sinica - November 28, 2018 Category: Drugs & Pharmacology Authors: Chen YB, Zhou ZY, Li GM, Xiao CX, Yu WB, Zhong SL, Cai YF, Jin J, Huang M Tags: Acta Pharmacol Sin Source Type: research

Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression.
Abstract Brain edema is a common and serious complication of ischemic stroke with limited effective treatment. We previously reported that methylene blue (MB) attenuated ischemic brain edema in rats, but the underlying mechanisms remained unknown. Aquaporin 4 (AQP4) in astrocytes plays a key role in brain edema. We also found that extracellular signal-regulated kinase 1/2 (ERK1/2) activation was involved in the regulation of AQP4 expression in astrocytes. In the present study, we investigated whether AQP4 and ERK1/2 were involved in the protective effect of MB against cerebral edema. Rats were subjected to transie...
Source: Acta Pharmacologica Sinica - July 13, 2020 Category: Drugs & Pharmacology Authors: Shi ZF, Fang Q, Chen Y, Xu LX, Wu M, Jia M, Lu Y, Wang XX, Wang YJ, Yan X, Dong LP, Yuan F Tags: Acta Pharmacol Sin Source Type: research

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
In this study we investigated whether Ori exerted a protective effect against reperfusion injury-induced neuronal loss and the underlying mechanisms. Mice were subjected to transient middle cerebral artery occlusion (tMCAO), and were injected with Ori (5, 10, 20 mg/kg, i.p.) at the beginning of reperfusion. We showed that Ori treatment rescued neuronal loss in a dose-dependent manner by specifically inhibiting caspase-9-mediated neuronal apoptosis and exerted neuroprotective effects against reperfusion injury. Furthermore, we found that Ori treatment reversed neuronal mitochondrial damage and loss after reperfusion injury....
Source: Acta Pharmacologica Sinica - October 10, 2022 Category: Drugs & Pharmacology Authors: Lei Li Jing-Jing Song Meng-Xue Zhang Hui-Wen Zhang Hai-Yan Zhu Wei Guo Cai-Long Pan Xue Liu Lu Xu Zhi-Yuan Zhang Source Type: research

Dietary salt intake and stroke.
PMID: 23274412 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Turlova E, Feng ZP Tags: Acta Pharmacol Sin Source Type: research

Restoring neuroprotection through a new preclinical paradigm: translational success for NA-1 in stroke therapy.
PMID: 23262667 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Instrum R, Sun HS Tags: Acta Pharmacol Sin Source Type: research