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Multiple Combination of Angelica gigas Extract and Mesenchymal Stem Cells Enhances Therapeutic Effect.
The objective of this research is validation of the enhanced effects of multiple combined treatment of AG extract with MSCs on stroke through angiogenesis. Our results confirmed that AG extract with MSCs improved the neovascularization increasing expression of angiogenesis-regulated molecules. The changes of brain and the behavioral ability showed the increased effects of AG extract with MSCs. As a result, AG extract and MSCs may synergistically increase the therapeutic potential by enhancing neovascularization. This mixed approach provides a new experimental protocol of herbal medicine therapy for the treatment of a varie...
Source: Biological and Pharmaceutical Bulletin - December 8, 2018 Category: Drugs & Pharmacology Authors: Kim R, Kim P, Lee CY, Lee S, Yun H, Lee MY, Kim J, Baek K, Chang W Tags: Biol Pharm Bull Source Type: research

Tetramethylpyrazine protects bone marrow-derived mesenchymal stem cells against hydrogen peroxide-induced apoptosis through PI3K/Akt and ERK1/2 pathways.
In conclusion, our results confirm that TMP protects BMSCs against H2O2-induced apoptosis by regulating the PI3K/Akt and ERK1/2 signaling pathways, suggesting that TMP may be used in combination with BMSCs to improve cell survival for the treatment of ischemic stroke. PMID: 28978811 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - October 4, 2017 Category: Drugs & Pharmacology Authors: Fang Y, Chu L, Li L, Wang J, Yang Y, Gu J, Zhang J Tags: Biol Pharm Bull Source Type: research