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The Temporospatial Role of Microcirculatory Dysfunction in the Prediction of Ischemia or Infarction in Patients with Aneurysmal Subarachnoid Hemorrhages (P2.281)
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zamora, A., Gupta, A., Leclerc, J., Vasilopoulos, T., Dore, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Pediatric Thrombectomy: Case Presentation and Standardizing the INR process. (P4.149)
Conclusions:Endovascular therapy should be considered in pediatric patients, and consensus guidelines and processes for implementation are needed to ensure this therapy is given appropriately, efficiently and safely.Disclosure: Dr. Bushlin has nothing to disclose. Dr. Wilson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bushlin, I., Wilson, J. Tags: Child Neurology II Source Type: research

Anesthesia and neurologic outcome of endovascular therapy in acute ischemic stroke: MR (not so) CLEAN
Recent trials have confirmed the effectiveness of endovascular mechanical thrombectomy for selected acute ischemic stroke patients with large artery occlusion, whose outcomes remained poor despite optimal medical management. Among many challenges for thrombectomy implementation is determining whether general anesthesia (GA) reduces the benefits of thrombectomy, as several recent studies suggest.1,2 Berkhemer et al.3 approach this question with a post hoc analysis of Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), the first prospective, randomized stud...
Source: Neurology - August 14, 2016 Category: Neurology Authors: Crosby, G., Muir, K. W. Tags: Stroke prevention, Infarction EDITORIALS Source Type: research

The effect of anesthetic management during intra-arterial therapy for acute stroke in MR CLEAN
Conclusions: In this post hoc analysis, we found that the type of anesthetic management influences outcome following IAT. Only treatment without general anesthesia was associated with a significant treatment benefit in MR CLEAN. Classification of evidence: This study provides Class II evidence that for patients with acute ischemic stroke undergoing IAT, mRS scores at 90 days improve only in patients treated without GA.
Source: Neurology - August 14, 2016 Category: Neurology Authors: Berkhemer, O. A., van den Berg, L. A., Fransen, P. S. S., Beumer, D., Yoo, A. J., Lingsma, H. F., Schonewille, W. J., van den Berg, R., Wermer, M. J. H., Boiten, J., Lycklama a Nijeholt, G. J., Nederkoorn, P. J., Hollmann, M. W., van Zwam, W. H., van der Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Embolism, Infarction ARTICLE Source Type: research

Outcome Predictors After Successful Intra-Arterial Therapy for Acute Ischemic Stroke (P1.195)
Conclusion: Age, NIHSS score, use of stent retrievers, mode of anesthesia, and symptomatic ICH might affect functional outcome in stroke patients who achieve successful recanalization via intra-arterial therapy. Prospective studies, or a meta-analysis of sub-groups in the recently published prospective trials are needed to confirm the association between those factors, or others, and functional outcome.Disclosure: Dr. Noufal has nothing to disclose. Dr. Mankad has nothing to disclose. Dr. Lakraj has nothing to disclose. Dr. Cox has nothing to disclose. Dr. Shirilla has nothing to disclose. Dr. Sattar has nothing to disclos...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Noufal, M., Mankad, J., Lakraj, A. A., Cox, J.-A., Shirilla, D., Sattar, A., Wazni, W., Sallowm, Y., Lynch, J., Zaidat, O. Tags: Acute Endovascular Therapy: Outcomes and Safety Source Type: research

Time is Brain: Standardized Neuro-Interventional Thrombectomy Protocols lead to Faster Recanalization Times (I6.005)
Conclusions:Our initiatives allowed us to refine our process of care, resulting in a significant reduction of time between patient arrival and CT imaging, CT imaging and femoral artery access, and groin puncture to recanalization.Disclosure: Dr. Frei has received personal compensation for activities with Microvention, Covidien, Stryker, Siemens, and Penumbra as a consultant. Dr. Caputo has nothing to disclose. Dr. McCarthy has nothing to disclose. Dr. Salottolo has nothing to disclose. Dr. Bar-Or has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Frei, D., Caputo, L., McCarthy, K., Salottolo, K., Bar-Or, D. Tags: Future Directions and Challenges in Stroke Team Action Therapy (STAT) Data Blitz Presentations Source Type: research

An Unusual Case of Acquired Alexia without Agraphia Caused by Perioperative Stroke (P4.368)
Conclusions: Though rare, perioperative strokes occur and are often unidentified. Proceduralists and anesthesiologists should not delay emergent neurological assessment for fear of treatment futility. Though many postoperative patients are not candidates for intravenous thrombolysis, endovascular catheter-based interventions can be considered.Disclosure: Dr. Sener has nothing to disclose. Dr. Siegel has nothing to disclose. Dr. Eidelman has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sener, U., Siegel, J., Eidelman, B. Tags: Cerebrovascular Case Reports Source Type: research

Continuous Intra-Arterial Catheter Access of Ischemic Cerebral Tissue (P5.229)
Conclusions: Continuous selective intra-arterial catheterization of the rat ICA using the described method is safe, does not compromise distal microvascular perfusion, and does not cause significant cerebral injury. Future studies will incorporate the procedure within a stroke model, establish continued patency, and deliver neuroprotective agents directly into the ischemic brain.Disclosure: Dr. Selvan has nothing to disclose. Dr. Barone has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Selvan, P., Barone, F. Tags: Cerebrovascular Disease: Animal Models and In Vitro Models Source Type: research

Time is Brain: Standardized Neuro-Interventional Thrombectomy Protocols lead to Faster Recanalization Times (S47.007)
Conclusions:Our initiatives allowed us to refine our process of care, resulting in a significant reduction of time between patient arrival and CT imaging, CT imaging and femoral artery access, and groin puncture to recanalization.Disclosure: Dr. Frei has received personal compensation for activities with Microvention, Covidien, Stryker, Siemens, and Penumbra as a consultant. Dr. Caputo has nothing to disclose. Dr. McCarthy has nothing to disclose. Dr. Salottolo has nothing to disclose. Dr. Bar-Or has nothing to disclose.
Source: Neurology - February 7, 2016 Category: Neurology Authors: Frei, D., Caputo, L., McCarthy, K., Salottolo, K., Bar-Or, D. Tags: IV-tPA and Endovascular Therapy Source Type: research

Standardizing Stroke Evaluation in the Cardiac Catheterization Lab: Aldrete-FAST Score (P7.330)
Conclusions: The Aldrete-FAST screening tool applied pre- and post-cardiac catheterization is a logical and feasible approach to improve rapid stroke diagnosis and treatment response. Recruitment is successfully underway with on-going prospective analysis as part of a quality initiative.Disclosure: Dr. Johansen has nothing to disclose. Dr. Southerland has received personal compensation in an editorial capacity for Neurology Podcast. Dr. Ragosta has nothing to disclose. Dr. Jensen has nothing to disclose. Dr. Worrall has received personal compensation in an editorial capacity for Neurology. Dr. Worrall has received royalty ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Johansen, M., Southerland, A., Ragosta, M., Jensen, M. L., Worrall, B., Solenski, N. Tags: Practice, Policy, and Ethics Source Type: research

Tactile unawareness in acute right hemispheric stroke (P1.207)
CONCLUSIONS:Tactile unawareness is common in acute right MCA stroke. Bedside findings can help dissociate primary sensory deficit from somatosensory hemi-inattention. The importance of spatial attention in tactile awareness is substantiated by the lesion sites associated with the disorder: regions crucial for multi-sensory integration and bodily awareness. Study Supported by:Disclosure: Dr. Antoniello has nothing to disclose. Dr. Gottesman has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Antoniello, D., Gottesman, R. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Attention and Aphasia Source Type: research

High-Fidelity Simulation Versus Traditional Didactic Techniques for Teaching Neurological Emergencies to Neurology Residents: A Feasibility Study. (P1.323)
CONCLUSIONS: Simulation based learning offers promise as a tool for objectively assessing some of the ACGME competencies that are more difficult to evaluate via traditional means. Studies with larger N and longer follow-up are needed to assess the efficacy, learner-retention and satisfaction rates among groups.Study supported by AAN education grant 2013.Disclosure: Dr. Agarwal has nothing to disclose. Dr. Dangayach has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Roque has nothing to disclose. Dr. Cappaert has nothing to disclose. Dr. Fowler has nothing to disclose. Dr. Claassen has nothing to disclose. Dr. ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Agarwal, S., Dangayach, N., Patel, P., Roque, A., Cappaert, M., Fowler, D., Claassen, J., Mayer, S. Tags: Neurology Education: Graduate Medical Education/Undergraduate Medical Education Source Type: research

Use of Apixaban and Warfarin in Patients Undergoing Procedures: Insights from ARISTOTLE (P5.002)
CONCLUSIONS: Procedures are common in patients with atrial fibrillation. The majority of procedures are non-major and non-emergent, and anticoagulation therapy is likely to be stopped peri-procedure. Overall and among emergent procedures, rates of clinical events in the first 30 days post-procedure were low and comparable between treatment groups.Study Supported by: Bristol-Myers Squibb Company and Pfizer Inc. Editorial assistance (i.e., formatting the abstract to ensure compliance with AAN guidelines) was provided by Claire Hall of Caudex Medical and was funded by Bristol-Myers Squibb Company and Pfizer Inc.Disclosure: Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lopes, R., Garcia, D., Wojdyla, D., Dorian, P., Alexander, J., Wallentin, L., Lanas, F., Hanna, M., Held, C., Granger, C. Tags: Cerebrovascular Disease and Interventional Neurology II Source Type: research

Downstream Clot Fragment Migration During Endovascular Clot Extraction Adversely Affects Clinical Outcome (P4.212)
Conclusion: Our results strongly suggest an adverse effect of downstream clot fragments. Awareness of this should become part of the approval and post-marketing evaluation of devices.Disclosure: Dr. Frey has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals, Inc., Bristol-Myers Squibb Co., EKT Pharma, Genentech Inc., and Sanofi-Aventis Pharmaceuticals Inc. Dr. Darbonne has nothing to disclose. Dr. Clark has nothing to disclose. Dr. Tucker has nothing to disclose. Dr. Chapple has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Frey, J., Darbonne, C., Clark, J., Tucker, A., Chapple, C. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

Use of Apixaban and Warfarin in Patients Undergoing Procedures: Insights from ARISTOTLE (I2-2.003)
CONCLUSIONS: Procedures are common in patients with atrial fibrillation. The majority of procedures are non-major and non-emergent, and anticoagulation therapy is likely to be stopped peri-procedure. Overall and among emergent procedures, rates of clinical events in the first 30 days post-procedure were low and comparable between treatment groups.Study Supported by: Bristol-Myers Squibb Company and Pfizer Inc. Editorial assistance (i.e., formatting the abstract to ensure compliance with AAN guidelines) was provided by Claire Hall of Caudex Medical and was funded by Bristol-Myers Squibb Company and Pfizer Inc.Disclosure: Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lopes, R., Garcia, D., Wojdyla, D., Dorian, P., Alexander, J., Wallentin, L., Lanas, F., Hanna, M., Held, C., Granger, C. Tags: New Antithrombotic Agents for Stroke Prevention Data Blitz Presentations Source Type: research

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