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Source: BMC Neurology

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Total 724 results found since Jan 2013.

Predictors of long-term survival among first-ever ischemic and hemorrhagic stroke in a Brazilian stroke cohort
Conclusions: For ischemic stroke, the lack of formal education and diabetes were significant independent predictors of poor long-term survival.
Source: BMC Neurology - May 24, 2013 Category: Neurology Authors: Alessandra GoulartTiotrefis FernandesItamar SantosAirlane AlencarIsabela BensenorPaulo Lotufo Source Type: research

Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design (Study protocol)
This study aims to test the hypothesis that above mentioned encoding gene polymorphisms are associated with stroke and to determine whether risk varies as per specific subtypes of stroke. Methods: The study design would be case--control study. Six hundred cases with diagnosis of stroke and 600 age and sex matched controls will be recruited. Controls will be matched in 1:1 ratio. Baseline and demographic data will be collected in standardized data collection form. Four ml of blood will be collected in EDTA coated vial and will be used for DNA isolation. Genotyping will be done by using PCR-RFLP method. For the reconfirmatio...
Source: BMC Neurology - October 3, 2013 Category: Neurology Authors: Amit KumarRam SagarPradeep KumarJitendra SahuAshoo GroverAchal SrivastavaS VivekanandhanKameshwar Prasad Source Type: research

Relevance of novel inflammatory markers in stroke-induced immunosuppression
Background: Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (SIIS), leading to severe complications in stroke patients. We aimed to identify an inflammatory marker that best represents this biphasic immunological response after AIS. Methods: We investigated the alteration of CRP, WBC, neutrophil count, suPAR levels, CD4+ CD25high Tregs, CD64+ and CD177+ neutrophils and monocytes in 12 acute ischemic stroke patients free of infection within 6 hours and one week after...
Source: BMC Neurology - March 6, 2014 Category: Neurology Authors: András FolyovichEnik¿ BiróCsaba OrbánAnna BajnokViktória VargaAnna Béres-MolnárBarna VásárhelyiGergely Toldi Source Type: research

Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry
Conclusions: In our region, Lombardia, adherence to guidelines in statin prescription at Stroke Unit discharge is very different from international goals. The presence of dyslipidemia remains the main factor influencing statin prescription, while the presence of well-defined atherosclerotic etiopathogenesis of stroke does not enhance statin prescription. Some uncertainties about the risk/benefit of statin therapy in stroke etiology subtypes (cardioembolism, other or undetermined causes) may partially justify the underuse of statin in ischemic stroke. The differences that exist between current international guidelines may p...
Source: BMC Neurology - March 21, 2014 Category: Neurology Authors: Canavero IsabellaCavallini AnnaPerrone PatriziaMagoni MauroSacchi LuciaQuaglini SilvanaLanzola GiordanoMicieli Giuseppe Source Type: research

Using antidepressants and the risk of stroke recurrence: report from a national representative cohort study
Conclusions: We demonstrated that use of antidepressants was associated with an increased risk of stroke recurrence, especially in ischemic stroke among Taiwanese. Further studies are warranted to confirm the possible underlying mechanisms of these findings.
Source: BMC Neurology - June 5, 2015 Category: Neurology Authors: Hsiao-Ting JuangPei-Chun ChenKuo-Liong Chien Source Type: research

Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) trial: protocol of a randomized clinical trial on tele-rehabilitation for stroke patients
The objective of the Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) trial is to determine if a novel tele-rehabilitation intervention for the first three months after stroke admission improves functional recovery compared to usual care.Methods/designThis is a single blind (evaluator blinded), parallel, two-arm randomised controlled trial study design involving 100 recent stroke patients. The inclusion criteria are age ≥40 years, having caregiver support and recent stroke defined as stroke diagnosis within 4 weeks. Consenting participants will be randomized with varying block size of 4 or 6 assuming a ...
Source: BMC Neurology - September 5, 2015 Category: Neurology Authors: Gerald KohShih YenArthur TayAngela CheongYee NgDeidre De SilvaCarolina PngKevin CavesKaren KohYogaprakash KumarShi PhanBee TaiCynthia ChenEffie ChewZhaojin ChaoChun ChuaYen KohHelen Hoenig Source Type: research

Temporal trends in stroke admissions in Denmark 1997--2009
Conclusion: This study found a constant rate of stroke hospitalization in Denmark from 1997--2009. The overall rate of hospitalized strokes adjusted for age decreased during this period.
Source: BMC Neurology - October 30, 2013 Category: Neurology Authors: Malene DemantCharlotte AnderssonOle AhlehoffMette CharlotJonas OlesenAnne GjesingPeter HansenGunnar GislasonThomas TruelsenChristian Torp-Pedersen Source Type: research

Biomarkers and perfusion - training-induced changes after stroke (BAPTISe): protocol of an observational study accompanying a randomized controlled trial
DiscussionThis exploratory study will be the first to investigate the effects of physical fitness training in patients with ischemic stroke on MRI-based cerebral perfusion, pertinent blood biomarker levels, and functional outcome. The study may have an impact on current patient rehabilitation strategies and reveal important information about the roles of MRI and blood-derived biomarkers in ischemic stroke.Trial registration: NCT01954797.
Source: BMC Neurology - December 11, 2013 Category: Neurology Authors: Alexander NaveJan KröberPeter BruneckerJochen FiebachJonathan ListUlrike GrittnerMatthias EndresAndreas MeiselAgnes FlöelMartin Ebinger Source Type: research

Biomarkers and perfusion ¿ training-induced changes after stroke (BAPTISe): protocol of an observational study accompanying a randomized controlled trial
DiscussionThis exploratory study will be the first to investigate the effects of physical fitness training in patients with ischemic stroke on MRI-based cerebral perfusion, pertinent blood biomarker levels, and functional outcome. The study may have an impact on current patient rehabilitation strategies and reveal important information about the roles of MRI and blood-derived biomarkers in ischemic stroke.Trial registrationNCT01954797.
Source: BMC Neurology - December 11, 2013 Category: Neurology Authors: Alexander NaveJan KröberPeter BruneckerJochen FiebachJonathan ListUlrike GrittnerMatthias EndresAndreas MeiselAgnes FlöelMartin Ebinger Source Type: research

Stroke knowledge among diabetics: a cross-sectional study on the influence of age, gender, education, and migration status
Background: Stroke campaigns are educating about the need to immediately contact the emergency medical system if symptoms occur. Despite higher stroke rates among patients with diabetics and some migrant populations, there are few data about stroke knowledge in these groups. Methods: We performed a cross-sectional questionnaire survey among 250 diabetes patients from Germany and Turkey in a primary care and diabetes practice center. The two-page questionnaire asked for stroke knowledge and socio-demographic data. Also, medical and communication data were obtained. Stroke knowledge was defined as good if a participant knew ...
Source: BMC Neurology - December 14, 2013 Category: Neurology Authors: Birgitta WeltermannYoucef Driouach-BleckmannSabrina ReindersPeter BerndtStefan Gesenhues Source Type: research

Young individuals with stroke: a cross sectional study of long-term disability associated with self-rated global health
Conclusion: The negative effects of stroke, on self-rated global health among young individuals living in the community, appear to be substantial, multi factorial and long-standing which call for interdisciplinary research collaborations and team measures by health care long-term.
Source: BMC Neurology - January 28, 2014 Category: Neurology Authors: Susanne PalmcrantzLotta Widén HolmqvistDisa Sommerfeld Source Type: research

Depression and anxiety symptoms post-stroke/ TIA: prevalence and associations in cross-sectional data from a regional stroke registry
We described cross-sectional prevalence of depression and anxiety symptoms using the Hospital Anxiety and Depression Scale (HADS). Data on clinical and demographic details was collected and univariable and multivariable analyses performed to describe associations with HADS scores. We examined those with a diagnosis of `stroke? and `TIA? as separate cohorts. Results: From 13,283 potentially eligible stroke patients in the registry, we had full HADS data on 4,079. Of the 3,584 potentially eligible TIA patients, we had full HADS data on 1,247 patients. Across the stroke cohort, 1181 (29%) had HADS anxiety scores suggestive of...
Source: BMC Neurology - October 1, 2014 Category: Neurology Authors: Niall BroomfieldTerence QuinnAzmil Abdul-RahimMatthew WaltersJonathan Evans Source Type: research

Three-year survival and recurrence after first-ever stroke: the Joinville stroke registry
Conclusions: Compared to other cohort studies conducted between 10 and 20 years ago in high-income countries, our recurrence rates and 3-year risk of death were similar. Among IS subtypes, we confirmed that CE has highest risk of death. The most common cause of death after a first-ever stroke is cardiovascular disease. This has implications for the uptake of current secondary preventive strategies and the development of new strategies.
Source: BMC Neurology - May 1, 2015 Category: Neurology Authors: Norberto CabralMilena MullerSelma FrancoAlexandre LongoCarla MoroVivian NagelRafaela LiberatoAdriana GarciaVanessa VenancioAnderson Gonçalves Source Type: research

A pragmatic approach to sonothrombolysis in acute ischaemic stroke: the Norwegian randomised controlled sonothrombolysis in acute stroke study (NOR-SASS)
DiscussionNOR-SASS is the first randomised controlled trial designed to test the superiority of contrast enhanced ultrasound treatment given ≤4½ hours after stroke onset in an unselected acute ischaemic stroke population eligible or not eligible for intravenous thrombolysis, with or without a defined arterial occlusion on CTA. If a positive effect and safety can be proven, contrast enhanced ultrasound treatment will be an option for all acute ischaemic stroke patients. EudraCT No 201200032341; www.clinicaltrials.gov NCT01949961.
Source: BMC Neurology - July 11, 2015 Category: Neurology Authors: Aliona NacuChristopher KvistadNicola LogalloHalvor NaessUlrike Waje-AndreassenAnne AamodtRagnar SolhoffChristian LundHåkon TobroOle RønningRolf SalvesenTitto IdiculaLars Thomassen Source Type: research

Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study
Background: Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods: We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin...
Source: BMC Neurology - July 30, 2015 Category: Neurology Authors: Jay ChoiJi LeeTai ParkYong-Jin ChoJong-Moo ParkKyusik KangKyung LeeSoo-Joo LeeYoungchai KoJun LeeJoon-Tae KimKyung-Ho YuByung-Chul LeeJae-Kwan ChaDae-Hyun KimJuneyoung LeeDong-Eog KimMyung JangBeom KimMoon-Ku HanHee-Joon BaeKeun-Sik Hong Source Type: research