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Specialty: Neurology
Source: Epilepsy Curr

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Total 106 results found since Jan 2013.

Neurologic Complications of Poverty: the Associations Between Poverty as a Social Determinant of Health and Adverse Neurologic Outcomes
This study summarizes the recent literature on poverty as it contributes to neurological disease.RECENT FINDINGS: Children growing up in poverty have increased risk for cognitive deficits and behavioral disorders as reported by Noble et al. (Dev Sci. 9(6):642-54, 2006) and Farah et al. (Brain Res. 1110(1):166-74, 2006) as well as worse outcomes when it comes to epilepsy management and disease course as discussed by Camfield et al. (Epilepsia. 57(11):1826-33, 2016). In adulthood, as the number of social determinants of health increases, the incidence of stroke and severe stroke increases significantly as reported by Reshetn...
Source: Epilepsy Curr - May 5, 2021 Category: Neurology Authors: Monica Maalouf Maureen Fearon Mary Clare Lipa Hannah Chow-Johnson Linda Tayeh Daniel Lipa Source Type: research

The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target
CONCLUSION: This review is intended to provide an overview of the structure, trafficking, and molecular mechanisms of ASIC1a in order to further elucidate the role of ASIC1a in epilepsy.PMID:33797385 | DOI:10.2174/1570159X19666210402102232
Source: Epilepsy Curr - April 2, 2021 Category: Neurology Authors: Yu Cheng Wuqiong Zhang Yue Li Ting Jiang Buhajar Mamat Yunhai Zhang Famin Wang Hongmei Meng Source Type: research

Clinician-Focused Overview and Developments in Polysomnography.
Abstract Purpose of Review: Polysomnography (PSG) represents a fundamental diagnostic tool used in the evaluation of sleep disorders. It represents a simultaneous recording of sleep staging, eye movements, electromyographic tone, respiratory parameters, and electrocardiogram. It is particularly helpful in the assessment of sleep-disordered breathing and its management, propensity for excessive sleepiness, complex behaviors during sleep, including motor disturbances of sleep, sleep-related epilepsy, and parasomnias. This review is intended to summarize the indications for PSG, the limitations and challenges of this...
Source: Epilepsy Curr - November 23, 2020 Category: Neurology Authors: Markun LC, Sampat A Tags: Curr Sleep Med Rep Source Type: research

Neuroprotective and Neurorestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases.
CONCLUSION: Because the Epo and VEGF signalling pathways are connected in several ways, we conclude that more experimental studies, primarily studies designed to thoroughly assess the functional interactions between Epo and VEGF in the brain under both physiological and pathophysiological conditions, are needed. PMID: 31942853 [PubMed - indexed for MEDLINE]
Source: Epilepsy Curr - November 20, 2020 Category: Neurology Authors: Ureña-Guerrero ME, Castañeda-Cabral JL, Rivera-Cervantes MC, Macias-Velez RJ, Jarero-Basulto JJ, Gudiño-Cabrera G, Beas-Zárate C Tags: Curr Pharm Des Source Type: research

The Potential Clinical Properties of Magnesium.
Abstract A significant percentage of costs in pharmaceutical markets is devoted to supplements, due to the confidence of consumers on the beneficial effects of these products. Magnesium is one of the supplements with enduring and increasing popularity. According to what is reported online this metal ion can cure, or prevent, almost all kind of diseases. This review aims at illustrating a series of scientifically demonstrated cases in which magnesium was used in clinical practice. Except for its ordinary use as antacid and laxative, other ascertained uses, reported in scientific literature, consist in helping to tr...
Source: Epilepsy Curr - November 16, 2020 Category: Neurology Authors: Crisponi G, Nurchi VM, Cappai R, Zoroddu MA, Gerosa C, Piras M, Faa G, Fanni D Tags: Curr Med Chem Source Type: research

Migraine Aura: Updates in Pathophysiology and Management.
Abstract PURPOSE OF REVIEW: To provide an updated review of the pathophysiology, diagnosis, and management of migraine with aura. RECENT FINDINGS: Thalamic and other subcortical regions may play a role in the pathophysiology of migraine. There is inter-patient and intra-patient attack variability in the characteristics of typical aura especially visual aura symptoms. Migraine with brainstem aura may originate cortically. Migraine with retinal aura may be associated with structural and functional changes in the retina. Although cortical spreading depression (CSD) continues to be the predominant theory surround...
Source: Epilepsy Curr - May 18, 2020 Category: Neurology Authors: Lai J, Dilli E Tags: Curr Neurol Neurosci Rep Source Type: research

Neuroprotective and Neurestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases.
CONCLUSION: Because the Epo and VEGF signalling pathways are connected in several ways, we conclude that more experimental studies, primarily studies designed to thoroughly assess the functional interactions between Epo and VEGF in the brain under both physiological and pathophysiological conditions, are needed. PMID: 31942853 [PubMed - as supplied by publisher]
Source: Epilepsy Curr - January 12, 2020 Category: Neurology Authors: Ureña-Guerrero ME, Castañeda-Cabral JL, Rivera-Cervantes MC, Macias-Velez RJ, Jarero-Basulto JJ, Gudiño-Cabrera G, Beas-Zárate C Tags: Curr Pharm Des Source Type: research

Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke.
Abstract PURPOSE OF REVIEW: In this review, we summarize the recent literature regarding the incidence and treatment of seizures arising after ischemic and hemorrhagic strokes. Additionally, we identify open questions in guidelines and standard clinical care to aid future studies aiming to improve management of seizures in post-stroke patients. RECENT FINDINGS: Studies demonstrate an increasing prevalence of seizures following strokes, probably a consequence of advances in post-stroke management and expanding use of continuous EEG monitoring. Post-stroke seizures are associated with longer hospitalization and...
Source: Epilepsy Curr - May 26, 2019 Category: Neurology Authors: Doria JW, Forgacs PB Tags: Curr Neurol Neurosci Rep Source Type: research

Recent developments in imaging of epilepsy.
Abstract PURPOSE OF REVIEW: Imaging constitutes one of the key pillars in the diagnostic workup after a first seizure as well as for the presurgical workup in epilepsy. The role of imaging in emergency situations, mainly to support the adequate diagnosis, as well as its role in planning of noninvasive image-guided therapies is less well established. Here, we provide an overview on peri-ictal imaging findings to support differential diagnosis in emergency situations and describe recent attempts toward minimal invasive therapy in the treatment of epilepsy and its comorbidities based on a combination of imaging techn...
Source: Epilepsy Curr - May 15, 2019 Category: Neurology Authors: Wiest R, Beisteiner R Tags: Curr Opin Neurol Source Type: research

Neurological diseases in pregnancy.
Abstract PURPOSE OF REVIEW: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed. RECENT FINDINGS: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Additionally, as more data is being published on medi...
Source: Epilepsy Curr - February 5, 2019 Category: Neurology Authors: Toscano M, Thornburg LL Tags: Curr Opin Obstet Gynecol Source Type: research

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences.
Abstract After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regulation of ionic currents and the facilitation of GABAergic over glutamatergic transmission. As a result, VPA indirectly modulates neurotransmitter release and strengthens the threshold for seizure activity. However, even though participating to the anticonvulsant action, such mechanisms seem to have minor impact on epileptogenesis. Nonetheless, VPA has been reported to exer...
Source: Epilepsy Curr - December 27, 2018 Category: Neurology Authors: Romoli M, Mazzocchetti P, D'Alonzo R, Siliquini S, Rinaldi VE, Verrotti A, Calabresi P, Costa C Tags: Curr Neuropharmacol Source Type: research

Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities.
Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affe...
Source: Epilepsy Curr - November 28, 2018 Category: Neurology Authors: Merelli A, Rodríguez JCG, Folch J, Regueiro MR, Camins A, Lazarowski A Tags: Curr Neuropharmacol Source Type: research

Cell Volume Control in Healthy Brain and Neuropathologies.
Abstract Regulation of cellular volume is a critical homeostatic process that is intimately linked to ionic and osmotic balance in the brain tissue. Because the brain is encased in the rigid skull and has a very complex cellular architecture, even minute changes in the volume of extracellular and intracellular compartments have a very strong impact on tissue excitability and function. The failure of cell volume control is a major feature of several neuropathologies, such as hyponatremia, stroke, epilepsy, hyperammonemia, and others. There is strong evidence that such dysregulation, especially uncontrolled cell swe...
Source: Epilepsy Curr - September 25, 2018 Category: Neurology Authors: Wilson CS, Mongin AA Tags: Curr Top Membr Source Type: research