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Cell Volume Control in Healthy Brain and Neuropathologies.
Abstract Regulation of cellular volume is a critical homeostatic process that is intimately linked to ionic and osmotic balance in the brain tissue. Because the brain is encased in the rigid skull and has a very complex cellular architecture, even minute changes in the volume of extracellular and intracellular compartments have a very strong impact on tissue excitability and function. The failure of cell volume control is a major feature of several neuropathologies, such as hyponatremia, stroke, epilepsy, hyperammonemia, and others. There is strong evidence that such dysregulation, especially uncontrolled cell swe...
Source: Epilepsy Curr - September 25, 2018 Category: Neurology Authors: Wilson CS, Mongin AA Tags: Curr Top Membr Source Type: research

A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders
Curr Drug Targets. 2022 Jan 17. doi: 10.2174/1389450123666220117104038. Online ahead of print.ABSTRACTNeurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any kind of structural, electrical, biochemical and functional abnormalities in neurons can lead to various types of disorders like Alzheimer's disease (AD), depression, Parkinson's disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential of complete treatment of an illness are highly desired. A range of small or...
Source: Epilepsy Curr - March 21, 2022 Category: Neurology Authors: Bhupinder Kumar Naveen Kumar Amandeep Thakur Vijay Kumar Rakesh Kumar Vinod Kumar Source Type: research