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Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Conclusions: Platelets may harbor proteins associated with HFpEF. S100A8 is present in the platelets of subjects with HFpEF and increased in the plasma of the same subjects. We further established a bedside-to-bench translational system that can be utilized as a secondary screen to ascertain whether the biomarkers may be an associated finding or causal to the disease process. S100A8 has been linked with other cardiovascular disease such as atherosclerosis and risk for myocardial infarction, stroke, or death. This is the first report on association of S100A8 with HFpEF.
Source: Journal of Translational Medicine - January 20, 2016 Category: Research Authors: Roseanne RaphaelDiana PurushothamCourtney GastonguayMarla ChesnikWai-Meng KwokHsiang-En WuSanjiv ShahShama MirzaJennifer Strande Source Type: research