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Source: Experimental Physiology

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Total 39 results found since Jan 2013.

Type 2 diabetes and older age contribute to elevated plasma microparticle concentrations independent of chronic stroke
Experimental Physiology,Volume 0, Issue ja, -Not available-.
Source: Experimental Physiology - July 31, 2018 Category: Physiology Authors: Rian Q.Landers ‐Ramos , Monica C.Serra , Jacob B.Blumenthal , Alice S.Ryan , Charlene E.Hafer‐Macko , Steven J.Prior Source Type: research

Neuroprotection by post ‐stroke administration of an oral formulation of angiotensin‐(1–7) in ischaemic stroke
Experimental Physiology,Volume 103, Issue 6, Page 916-923, 1 June 2018.
Source: Experimental Physiology - June 1, 2018 Category: Physiology Authors: Douglas M.Bennion , Chad H.Jones , Lauren L.Donnangelo , Justin T.Graham , Jacob D.Isenberg , Alex N.Dang , VermaliRodriguez , Ruben D. M.Sinisterra , Frederico B.Sousa , Robson A. S.Santos , ColinSumners Source Type: research

The haemodynamic response to incremental increases in negative intrathoracic pressure in healthy humans
New Findings What is the central question of this study? The haemodynamic response to incremental increases in negative intrathoracic pressure (nITP) during spontaneous breathing and the mechanisms of cardiac impairment at these levels of nITP remain unclear. What is the main finding and its importance? nITP of −20 cmH2O or greater reduces stroke volume in healthy, spontaneously breathing supine humans due to direct ventricular interaction and increased left ventricular afterload. AbstractNegative intrathoracic pressure (nITP) generally augments venous return and left ventricular (LV) stroke volume (LVSV), though lar...
Source: Experimental Physiology - March 2, 2018 Category: Physiology Authors: William S. Cheyne, Jinelle C. Gelinas, Neil D. Eves Tags: RESEARCH PAPER Source Type: research

Spinal cord injury ‐induced cardiomyocyte atrophy and impaired cardiac function are severity dependent
New Findings What is the central question of this study? How does the severity of spinal cord injury affect left ventricular mechanics, function and the underlying cardiomyocyte morphology? What is the main finding and its importance? Here, we show that severe, but not moderate, spinal cord injury causes cardiomyocyte atrophy, altered left ventricular mechanics and impaired cardiac function. The principal aim of the present study was to assess how the severity of spinal cord injury (SCI) affects left ventricular (LV) mechanics, function and underlying cardiomyocyte morphology. Here, we used different severities of T3 sp...
Source: Experimental Physiology - January 9, 2018 Category: Physiology Authors: Jordan W. Squair, Jie Liu, Wolfram Tetzlaff, Andrei V. Krassioukov, Christopher R. West Tags: Research Paper Source Type: research

The hemodynamic response to incremental increases in negative intrathoracic pressure in healthy humans
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - January 1, 2018 Category: Physiology Authors: William S. Cheyne, Jinelle C. Gelinas, Neil D. Eves Tags: RESEARCH PAPER Source Type: research

Reduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanics
In conclusion, a preload reduction during blood volume extraction does not result in compensatory changes in stroke volume or cardiac mechanics. Our data suggest that LV strain is dependent on LV filling and consequent geometry whereas LV twist could be mediated by heart rate. This article is protected by copyright. All rights reserved
Source: Experimental Physiology - January 1, 2018 Category: Physiology Authors: Rachel Lord, David MacLeod, Keith George, David Oxborough, Rob Shave, Mike Stembridge Tags: RESEARCH PAPER Source Type: research

Why do African American have a higher risk for cerebral disease?
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - January 1, 2018 Category: Physiology Authors: Shigehiko Ogoh Tags: VIEWPOINT Source Type: research

Spinal cord injury induced cardiomyocyte atrophy and impaired cardiac function are severity dependent
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - December 1, 2017 Category: Physiology Authors: Jordan W. Squair, Jie Liu, Wolfram Tetzlaff, Andrei V. Krassioukov, Christopher R. West Tags: Research Paper Source Type: research

Hyperbaric oxygenation and 20 ‐hydroxyeicosatetreanoic acid inhibition reduce stroke volume in female diabetic Sprague–Dawley rats
New Findings What is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation (HBO2) exposures on the outcome of cerebral tissue injury induced by a transient middle cerebral artery occlusion model in diabetic female rats? Are 20‐hydroxyeicosatetreanoic acid and epoxyeicosatrienoic acids involved? What is the main finding and its importance? Equal reduction of cortical and total infarct size in rats treated with HBO2 and HET0016 (20‐hydroxyeicosatetreanoic acid production inhibitor) and significant mRNA upregulation of epoxyeicosatrienoic...
Source: Experimental Physiology - November 2, 2017 Category: Physiology Authors: Mihael Mi šir, Marija Renić, Sanja Novak, Martina Mihalj, Anita Ćosić, Monika Vesel, Ines Drenjančević Tags: Research Paper Source Type: research

Circulating leucocytes perpetuate stroke ‐induced aortic dysfunction
Experimental Physiology, Page 1321-1331, April 2018.
Source: Experimental Physiology - September 2, 2017 Category: Physiology Authors: ShinichiAsano , Grant C.O'Connell , Kent C.Lemaster , Evan R.DeVallance , Kayla W.Branyan , James W.Simpkins , Jefferson C.Frisbee , Taura L.Barr , Paul D.Chantler Source Type: research