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Source: Mol Biol Cell
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Total 73 results found since Jan 2013.
Management of Acute Cerebral Infarction by Intravenous Thrombolysis with Recombinant T Cell Receptor and Plasminogen Activator and Association of Emergency Nursing Route in the Prognosis
In this study, 100 patients were randomly selected that were equally divided into experimental and control groups. The period of hospital admission, the results of the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE), the results of the Glasgow Outcome Scale (GOS), and the results of the Activities of Daily Living were all analysed before and after the intervention.. Both the amount of time it took to get a diagnosis after being admitted and the amount of time it took to receive specialised therapy after receiving a diagnosis were significantly reduced in the observation group (both P value...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Yuqi Liu None Chengyong Wang None Yuanpeng Han Source Type: research
Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer's disease: a hypothesis
Mol Biol Rep. 2023 Aug 24. doi: 10.1007/s11033-023-08729-2. Online ahead of print.ABSTRACTIn the 1970s, Circular RNAs (CircRNAs) were first discovered in RNA viruses as viroids and were initially assumed to be RNA splicing defects. The roles and topologies of these circular RNA loops were later revealed using computer analysis and RNA-sequencing. They were found to demonstrate various functions, including protein scaffolding, parental gene regulation, microRNA sponges, and RNA-protein interactions. CircRNAs play a crucial role in controlling gene expression and are essential for biological development and illness detection...
Source: Mol Biol Cell - August 24, 2023 Category: Molecular Biology Authors: Mahima Singh Ajay Guru Raghul Murugan Muthukaruppan Gopi Jesu Arockiaraj Source Type: research
Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research
Clinical Effect of Shibing Xingnao Granules on Vascular Dementia Patients and Its Effect on Serum Neuronal Apoptosis Molecules
Cell Mol Biol (Noisy-le-grand). 2023 Feb 28;69(2):144-149. doi: 10.14715/cmb/2023.69.2.24.ABSTRACTIt was intended to study the clinical effect of Shibing Xingnao Granules on patients with vascular dementia (VD) and to explore its effect on serum neuronal apoptosis molecule levels in VD patients. For this purpose, 78 VD patients, as research objects, were grouped into a control group (acupuncture therapy) and an observation group (acupuncture therapy + Shibing Xingnao Granules) using the random number table method, with 39 cases per group. The clinical effect, cognitive function, neurological function, activity of daily liv...
Source: Mol Biol Cell - May 24, 2023 Category: Molecular Biology Authors: Hui Liu Yan Liu Peiyang Sun Jie Wu Lei Sheng Peifang Li Source Type: research
Effects of Bacterial Biofilm on Regulation of Neurovascular Unit Functions and Neuroinflammation of Patients with Ischemic Cerebral Stroke by Immunocyte
In conclusion, the formation of biofilm led to the aggravation of neurological impairment and inflammatory reactions among patients with ischemic cerebral stroke.PMID:37213153 | DOI:10.14715/cmb/2022.69.1.14
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Yongsheng Wu Demin Yang Source Type: research
Examination of ADRB2 gene expression and influence of Dexmedetomidine and Propofol on Hemodynamics after Abdominal Surgery
This study aimed to investigate ADRB2 gene expression and further understand the effects of dexmedetomidine on cardiac output and oxygen metabolism in tissues and organs by comparing the changes in hemodynamics after the patient has been sedated with dexmedetomidine and propofol after abdominal surgery. A total of 84 patients were randomly divided into the Dexmedetomidine Group (DEX Group with 40 cases) and Propofol Group (PRO Group with 44 cases). For the DEX Group, dexmedetomidine was used for sedation (loading dose: 1 ug/kg, infused for 10min; maintenance dose: 0.3ug/kg/h ~); for the PRO Group, propofol was used for sed...
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Zongqin Lin Herong Bu Xiaomei Huang Source Type: research
Effects of Bacterial Biofilm on Regulation of Neurovascular Unit Functions and Neuroinflammation of Patients with Ischemic Cerebral Stroke by Immunocyte
In conclusion, the formation of biofilm led to the aggravation of neurological impairment and inflammatory reactions among patients with ischemic cerebral stroke.PMID:37213153 | DOI:10.14715/cmb/2022.69.1.14
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Yongsheng Wu Demin Yang Source Type: research
Examination of ADRB2 gene expression and influence of Dexmedetomidine and Propofol on Hemodynamics after Abdominal Surgery
This study aimed to investigate ADRB2 gene expression and further understand the effects of dexmedetomidine on cardiac output and oxygen metabolism in tissues and organs by comparing the changes in hemodynamics after the patient has been sedated with dexmedetomidine and propofol after abdominal surgery. A total of 84 patients were randomly divided into the Dexmedetomidine Group (DEX Group with 40 cases) and Propofol Group (PRO Group with 44 cases). For the DEX Group, dexmedetomidine was used for sedation (loading dose: 1 ug/kg, infused for 10min; maintenance dose: 0.3ug/kg/h ~); for the PRO Group, propofol was used for sed...
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Zongqin Lin Herong Bu Xiaomei Huang Source Type: research
The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients
Curr Issues Mol Biol. 2023 Apr 5;45(4):3146-3167. doi: 10.3390/cimb45040205.ABSTRACTMany investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins low...
Source: Mol Biol Cell - May 15, 2023 Category: Molecular Biology Authors: Roxana Nartea Brindusa Ilinca Mitoiu Ioana Ghiorghiu Source Type: research
The effect of bempedoic acid an ATP-citrate lyase inhibitor on cardiovascular risk factors in rats with experimentally induced myocardial infarction and hyperlipidemia
Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(10):94-99. doi: 10.14715/cmb/2022.68.10.15.ABSTRACTControl of hyperlipidemia is believed to reduce major cardiovascular events such as cardiovascular death, myocardial infarction, nonfatal stroke, hospitalization for unstable angina, and coronary revascularization. The benefits of monotherapy with Bempedoic acid (BA) as a hypolipidemic agent given after induction of myocardial infarction (MI) in reducing the risk of acute MI worth being investigated, therefore this study was designed to investigate the effectiveness of Bempedoic acid on reducing cardiovascular risk factors in ...
Source: Mol Biol Cell - April 28, 2023 Category: Molecular Biology Authors: Mahmood Salim Yaseen Nidhal Mohammed Ali Source Type: research
Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
CONCLUSIONS: Our study provides, for the first time, evidence for the role of oscillatory shear stress in mediating the EndMT process and dysregulated expression of cell adhesion molecules, especially multifunctional integrin α9/β1 in human cAVM nidus. Concomitantly, our findings indicate the potential use of small-molecular inhibitors such as RO4929097 in the less-invasive therapeutic management of cAVMs.PMID:36934253 | PMC:PMC10024393 | DOI:10.1186/s11658-023-00436-x
Source: Mol Biol Cell - March 19, 2023 Category: Molecular Biology Authors: C L Karthika Vani Venugopal B J Sreelakshmi S Krithika Jaya Mary Thomas Mathew Abraham C C Kartha Arumugam Rajavelu S Sumi Source Type: research
