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Specialty: Molecular Biology
Source: Mol Biol Cell

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Total 73 results found since Jan 2013.

Neural Stem Cell Transplantation into a Mouse Model of Stroke.
Abstract Stroke is the fifth leading cause of death among Americans each year. Current standard-of-care treatment for stroke deploys intravenous tissue-type plasminogen activator (tPA), mechanical thrombolysis, or delivery of fibrinolytics. Although these therapies have reduced stroke-induced damage, therapeutic options still remain limited. Transplantation of patient-specific neural stem (NS) cells represents a promising strategy for the treatment of stroke. Basic science research has shown that transplanted NS cells can differentiate in the brain of rodent models of stroke and promote behavioral recovery. Clinic...
Source: Mol Biol Cell - June 10, 2019 Category: Molecular Biology Authors: De Los Angeles A Tags: Methods Mol Biol Source Type: research

The study of serum C-reactive protein, Serum cystatin C, and carbohydrate antigen 125 in patients with acute ischemic stroke
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):89-95. doi: 10.14715/cmb/2022.68.5.12.ABSTRACTStroke is the most common, deadly, and complicating neurological disease. Many studies have shown that the levels of some acute inflammatory reactants in people with ischemic stroke are higher than average. Therefore, in this study, three acute inflammatory reactants, i.e., C-reactive protein, Serum cystatin C, and carbohydrate antigen 125, were evaluated in patients with acute ischemic stroke to consider the association between these serums with intra and extra-cerebral vessels stenosis. In this cross-sectional study, 90 patien...
Source: Mol Biol Cell - August 27, 2022 Category: Molecular Biology Authors: Xiaoqian Lin Chunyu Yu Hongmei Ding Xiuping Ma Fengning Guo Dan Chen Youmin Fan Source Type: research

Tug1 Acts on ERK12 Signaling Pathway to Aggravate Neuronal Damage after Acute Ischemic Stroke
This study mainly considers the role of lncRNA tug 1 on the ERK 12 signaling pathway to enhance neuronal damage after acute ischemic stroke. In the experiment, the middle cerebral artery occlusion (MCAO) model was constructed using the thread embolization method. The real-time quantitative RT-CR method was used to detect the relative transcriptional activity of TG1, GAS5 and SM22a genes in tissues. The relative expression level of SM22a protein in tissues was detected by the immune-histochemical method. Twenty-four hours after cerebral infarction, the nerve function, cerebral infarction area and ERK1/2 protein expression l...
Source: Mol Biol Cell - July 9, 2022 Category: Molecular Biology Authors: Xiaojie Chen Yuduan Xie Chunling Liang Dawei Yang Xiaotao Li Jie Yu Source Type: research

The effect of nursing and rehabilitation measures on quality of life and expression of Bax/Bcl2 genes in patients with stroke
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):111-116. doi: 10.14715/cmb/2022.68.5.15.ABSTRACTStroke is the leading cause of neurological problems and the third leading cause of death globally, leading to various neurological defects. Due to the importance of applying nursing and rehabilitation measures to reduce complications in these patients, a study was conducted to determine the effect of nursing and rehabilitation measures on the quality of life of patients with stroke. This two-stage experimental study (before and after) was performed on 20 patients with stroke admitted to the internal medicine department. Patie...
Source: Mol Biol Cell - August 27, 2022 Category: Molecular Biology Authors: Beibei Zhang Jing Li Jianyong Chen Source Type: research

Bioinformatic Prediction of Depression-Related Signaling Pathways Regulated by miR-146a in Peripheral Blood of Patients with Post-Stroke Depression
In conclusion, the expression level of miR-146a-5p was abnormally increased in PSD patients, and it could be taken as a candidate marker for the diagnosis of PSD. miR-146a-5p could affect PSD through signaling pathways of TLRs, neurotrophic factors, and NF-κB.PMID:36227679 | DOI:10.14715/cmb/2022.68.6.7
Source: Mol Biol Cell - October 13, 2022 Category: Molecular Biology Authors: Zhimin Chen Na Wang Risu Na Haiyan Yu Dan Sui Bing Cui Lihua Wang Source Type: research

Isolation and Purification of Self-Renewable Human Neural Stem Cells from iPSCs for Cell Therapy in Experimental Model of Ischemic Stroke
Methods Mol Biol. 2022;2389:165-175. doi: 10.1007/978-1-0716-1783-0_14.ABSTRACTNeural stem cell therapy has been galvanized by the discovery of pluripotent stem cells. The possibility to generate specialized central nervous system-specific differentiated cells using human somatic cells engineered to become induced pluripotent stem cells (iPSCs) was a game changer. This technology has broad applications in the field of regenerative medicine, in vitro disease modeling, targeted drug discovery, and precision medicine. Currently, iPSCs are one of the most promising cell sources amenable for commercialization and off-the-shelf ...
Source: Mol Biol Cell - September 24, 2021 Category: Molecular Biology Authors: Marcel M Daadi Source Type: research

Effect of Acupuncture Treatment on Post-stroke Depression by Using Diamond-Like Ultra-Thin Nano-Coating Technology
This study aimed to explore the effect of acupuncture on account of composite diamond-like nano-membrane sensors (DLNF) sensors on post-stroke depression. Titanium/antigen-diamond-like carbon (Ti/Ag-DLC) composite DLNF sensors were prepared by coating Ti and Ag composites on the surface of DLC by radio frequency magnetron sputtering technology. The scanning electron microscope (SEM), X-ray photoelectron spectrometer (XPS), Raman spectrometer, nanoindenter, and sliding friction tester were adopted to analyze the characterization of Ti/Ag-DLC composite membrane, the chemical state of the main constituent elements on the surf...
Source: Mol Biol Cell - August 21, 2022 Category: Molecular Biology Authors: Ting Yang Ruidong Cheng Jie Zhang Liang Tian Peng Sun Xiangming Ye Source Type: research

Effects of Bacterial Biofilm on Regulation of Neurovascular Unit Functions and Neuroinflammation of Patients with Ischemic Cerebral Stroke by Immunocyte
In conclusion, the formation of biofilm led to the aggravation of neurological impairment and inflammatory reactions among patients with ischemic cerebral stroke.PMID:37213153 | DOI:10.14715/cmb/2022.69.1.14
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Yongsheng Wu Demin Yang Source Type: research