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Source: Cancer Control
Vaccination: Cancer Vaccines
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Total 661 results found since Jan 2013.
Pediatric hematology and oncology physician and nurse practitioner views of the HPV vaccine and barriers to administration
Hum Vaccin Immunother. 2023 Aug 1;19(2):2224089. doi: 10.1080/21645515.2023.2224089.ABSTRACTRates of Human papilloma virus (HPV) vaccination among pediatric survivors of cancer and patients with sickle cell disease are lower than the national average. While recent attention has focused on patient HPV vaccine hesitancy and refusal, less is known about provider-level and system-level barriers to vaccinations in pediatric hematology/oncology (PHO) populations. Applying thematic analysis to qualitative interviews with 20 pediatric hematology/oncology physicians and nurse practitioners, we examine their views regarding HPV vacc...
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Meagan E Miller Mahvish Q Rahim Scott L Coven Seethal A Jacob Gregory D Zimet Carolyn G Meagher Mary A Ott Source Type: research
An investigation on cervical cancer and human papillomavirus vaccine knowledge, and analysis of influencing factors for choosing domestic or imported 2vHPV vaccine among females in Shenzhen, China
In conclusion, eligible female recipients had a high degree of knowledge regarding cervical cancer and HPV vaccine, education level and occupation were the most important factors for scores. Domestic 2vHPV vaccine was more widely utilized than imported, manufacturer, efficacy, safety, cognitive approach, public opinion, convenient acquisition, and knowledge reserve had an impact on selection for recipients, while price and doctor's suggestion did not.PMID:37350143 | DOI:10.1080/21645515.2023.2225389
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Linxiang Chen Fangfang Lu Ziqi Wang Hanqing Chen Mianling Chen Chunmiao Peng Kangming Chen Cuili Chen Huawei Xiong Xu Xie Source Type: research
Predictors of SARS-CoV-2 Omicron breakthrough infection after receipt of AZD7442 (tixagevimab-cilgavimab) for pre-exposure prophylaxis among hematologic malignancy patients
Haematologica. 2023 Jun 22. doi: 10.3324/haematol.2023.283015. Online ahead of print.ABSTRACTAZD7442 (tixagevimab-cilgavimab) is a combination of two human monoclonal antibodies for preexposure prophylaxis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among highrisk patients who do not mount a reliable vaccine response. Foremost among these are hematologic malignancy patients with limited clinical trial or real-world experience to assess the effectiveness of this combination treatment since the emergence of Omicron and its subvariants. We performed a retrospective study of 892 highrisk hematolog...
Source: Cancer Control - June 22, 2023 Category: Cancer & Oncology Authors: Justin C Laracy Judy Yan Samantha N Steiger Carrie A Tan Nina Cohen Elizabeth V Robilotti Jerome Fender Sara Cohen Neha Korde Melissa Lee-Teh Ariela Noy Joseph H Oved Lindsey E Roeker Gunjan Shah N Esther Babady Mini Kamboj Susan K Seo Source Type: research
Recent Advances in Molecular Mechanisms of Cancer Immunotherapy
Cancers (Basel). 2023 May 11;15(10):2721. doi: 10.3390/cancers15102721.ABSTRACTCancer is among the current leading causes of death worldwide, despite the novel advances that have been made toward its treatment, it is still considered a major public health concern. Considering both the serious impact of cancer on public health and the significant side effects and complications of conventional therapeutic options, the current strategies towards targeted cancer therapy must be enhanced to avoid undesired toxicity. Cancer immunotherapy has become preferable among researchers in recent years compared to conventional therapeutic...
Source: Cancer Control - June 22, 2023 Category: Cancer & Oncology Authors: Mateusz Kciuk Esam Bashir Yahya Montaha Mohamed Ibrahim Mohamed Summya Rashid Muhammad Omer Iqbal Renata Kontek Muhanad A Abdulsamad Abdulmutalib A Allaq Source Type: research
Antigen/Adjuvant-Displaying Enveloped Viral Replica as a Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidate
This study represents a pioneering example of precise vaccine design through bottom-up construction and opens new avenues for the development of effective vaccines.PMID:37344812 | DOI:10.1021/jacs.3c02679
Source: Cancer Control - June 21, 2023 Category: Cancer & Oncology Authors: Keita Ito Hiroto Furukawa Hiroshi Inaba Shino Ohshima Yoshie Kametani Masatoshi Maeki Manabu Tokeshi Xuhao Huang Kazuya Kabayama Yoshiyuki Manabe Koichi Fukase Kazunori Matsuura Source Type: research
Paxlovid for Treating COVID-19 Patients: A Case-Control Study From Two Hospitals in the Eastern Province of Saudi Arabia
Conclusion This study suggests that Paxlovid is highly effective in reducing the risk of severe COVID-19 or mortality. However, larger studies with better qualities are needed for a full assessment of the role of Paxlovid in COVID-19 management in Saudi Arabia.PMID:37337482 | PMC:PMC10277155 | DOI:10.7759/cureus.39234
Source: Cancer Control - June 20, 2023 Category: Cancer & Oncology Authors: Ali Alsaeed Abdullah Alkhalaf Ali Alomran Walaa Alsfyani Fadhel Alhaddad Mousa J Alhaddad Source Type: research
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection
Signal Transduct Target Ther. 2023 Jun 19;8(1):252. doi: 10.1038/s41392-023-01495-4.ABSTRACTThe COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominantly induced by the BA.5 subvariant. It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection, coupled with a variety of immune background, is sufficient to shape the immune responses against newly emerged Omicron subvariants, especially for XBB lineages. To investigate this, we collected s...
Source: Cancer Control - June 19, 2023 Category: Cancer & Oncology Authors: Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei Source Type: research
The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis
Int J Biol Sci. 2023 May 29;19(9):2879-2896. doi: 10.7150/ijbs.84994. eCollection 2023.ABSTRACTCholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D, DHCR7, IDI1/2. Especially, HMGCR, SQLE, FDFT1, LSS, FDPS, CYP51, and EBP are promising therapeutic targets for drug development due to many drugs have been approved and entered into clinical research by targeting these genes. However, new targets and drugs still need to be discover...
Source: Cancer Control - June 16, 2023 Category: Cancer & Oncology Authors: Wujun Chen Jiazhen Xu Yudong Wu Bing Liang Mingzhe Yan Chuandong Sun Dong Wang Xiaokun Hu Li Liu Wenchao Hu Yingchun Shao Dongming Xing Source Type: research
Evaluation of the Therapeutic Effect of Quadrivalent Human Papillomavirus (HPV) Vaccination on Cervical Intraepithelial Neoplasia Lesions
Indian J Surg Oncol. 2023 Jun;14(2):504-509. doi: 10.1007/s13193-022-01657-w. Epub 2022 Oct 1.ABSTRACTCervical cancer is the most common health problem among global young women. Cervical intraepithelial neoplasia (CIN) is a pre-invasive stage of cervical cancer, the major cause of which is human papillomavirus (HPV), and vaccination has a promising effect on reducing the progression of CIN lesions. The current study was a retrospective case control investigation in two centers, Shiraz and Sari Universities of Medical Sciences from 2018 to 2020 to evaluate the effect of quadrivalent HPV vaccination on CIN lesions (I, II, an...
Source: Cancer Control - June 16, 2023 Category: Cancer & Oncology Authors: Zahra Shiravani Zinab Nazari Freshteh Yazdani Fatemeh Sadat Najib Mojgan Akbarzadeh Jahromi Mozhdeh Momtahan Sara Pourseyed Shaghayegh Moradialamdarloo Mojgan Hajisafari Tafti Source Type: research
Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines
CONCLUSIONS: This study demonstrates the utility of bacterial spores for mucosal vaccination to H. pylori infection. The heat stability and robustness of Bacillus spores coupled with their existing use as probiotics make them an attractive solution for either protection against H. pylori infection or potentially for therapy and control of active infection.PMID:37314018 | DOI:10.1111/hel.12997
Source: Cancer Control - June 14, 2023 Category: Cancer & Oncology Authors: Paidamoyo M Katsande Van Duy Nguyen Thi Lan Phuong Nguyen Thi Kim Cuc Nguyen Gabrielle Mills David M D Bailey Graham Christie Huynh Anh Hong Simon M Cutting Source Type: research
Reducedhumoral response against variants of concern in childhood solid cancer patients compared to adult patients and healthy children after SARS-CoV-2 vaccination
CONCLUSIONS: The humoral response against VOCs after the CoronaVac vaccination in CCP was moderately impaired although the vaccine was safe. Age and chemotherapy time seem to be the primary reason for poor response and low serology levels.PMID:37304300 | PMC:PMC10247972 | DOI:10.3389/fimmu.2023.1110755
Source: Cancer Control - June 12, 2023 Category: Cancer & Oncology Authors: Yifei Ma Bocen Chen Yanqi Wang Pengfei Zhu Nianqi Liu Zhiying Zhang Guanqing Zhong Guangzhen Fu Dao Wang Lu Cao Shenrui Bai Youlong Wang Shuqin Chen Xiaolong Wei Jun Lv Ao Zhang Xinjia Wang Source Type: research
Rapid construction of infectious clones for distinct Newcastle disease virus genotypes
Front Vet Sci. 2023 May 25;10:1178801. doi: 10.3389/fvets.2023.1178801. eCollection 2023.ABSTRACTThe reverse genetics system of the Newcastle disease virus (NDV) has provided investigators with a powerful approach to understand viral molecular biology and vaccine development. It has been impressively improved with modified strategies since its first report, but it still poses some challenges. Most noteworthy, the genome complexity and length made full-length error-free cDNA assembly the most challenging and time-consuming step of NDV rescue. In the present study, we report a rapid full-length NDV genome construction with o...
Source: Cancer Control - June 12, 2023 Category: Cancer & Oncology Authors: Zuhua Yu Yuhao Zhang Zedian Li Qingzhong Yu Yanyan Jia Chuan Yu Jian Chen Songbiao Chen Lei He Source Type: research
Vaccine-induced protection against SARS-CoV-2 requires IFN- γ-driven cellular immune response
Nat Commun. 2023 Jun 10;14(1):3440. doi: 10.1038/s41467-023-39096-y.ABSTRACTThe overall success of worldwide mass vaccination in limiting the negative effect of the COVID-19 pandemics is inevitable, however, recent SARS-CoV-2 variants of concern, especially Omicron and its sub-lineages, efficiently evade humoral immunity mounted upon vaccination or previous infection. Thus, it is an important question whether these variants, or vaccines against them, induce anti-viral cellular immunity. Here we show that the mRNA vaccine BNT162b2 induces robust protective immunity in K18-hACE2 transgenic B-cell deficient (μMT) mice. We fu...
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Xiaolei Wang Terrence Tsz-Tai Yuen Ying Dou Jingchu Hu Renhao Li Zheng Zeng Xuansheng Lin Huarui Gong Celia Hoi-Ching Chan Chaemin Yoon Huiping Shuai Deborah Tip-Yin Ho Ivan Fan-Ngai Hung Bao-Zhong Zhang Hin Chu Jian-Dong Huang Source Type: research
Dying tumor cells-inspired vaccine for boosting humoral and cellular immunity against cancer
J Control Release. 2023 Jun 6:S0168-3659(23)00357-7. doi: 10.1016/j.jconrel.2023.05.044. Online ahead of print.ABSTRACTWhole tumor cells can act as effective antigen depots and have been regarded as prospective candidate for cancer vaccines. However, the clinical outcomes of whole tumor cell vaccine were restricted by the poor immunogenicity and potential in vivo oncogenicity risks. Herein, a simple and effective cancer vaccine named frozen dying tumor cells (FDT) was constructed to initiate a cascade of immune attacks against cancer. By introducing immunogenic dying tumor cells and integrating cryogenic freezing technolog...
Source: Cancer Control - June 8, 2023 Category: Cancer & Oncology Authors: Xianya Qin Ting Yang Hongbo Xu Runzan Zhang Siyu Zhao Li Kong Conglian Yang Zhiping Zhang Source Type: research
Prostate-specific antigen level association with COVID-19 infection and vaccination
CONCLUSION: SARS-CoV-2 infection and vaccinations are associated with a slight increase in PSA, with the third anti-COVID vaccine dose having a more prominent impact, but its clinical significance is unknown yet. Any significant increase in PSA must be investigated and cannot be dismissed as secondary to SARS-CoV-2 infection or vaccination.PMID:37270370 | PMC:PMC10159928 | DOI:10.1016/j.clgc.2023.05.001
Source: Cancer Control - June 3, 2023 Category: Cancer & Oncology Authors: Michael Frumer Shachar Moshe Aharony Ohad Shoshany Daniel Kedar Jack Baniel Shay Golan Source Type: research
