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Specialty: Universities & Medical Training
Source: Acta Med Okayama
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Total 9281 results found since Jan 2013.
A Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis
Acta Med Okayama. 2023 Aug;77(4):439-442. doi: 10.18926/AMO/65757.ABSTRACTA three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This sugge...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Takahiro Shiwaku Hisashi Ishida Yasuhisa Tatebe Kosuke Tamefusa Motoharu Ochi Kaori Fujiwara Toshihide Kubo Eiji Nakata Kana Washio Hirokazu Tsukahara Source Type: research
A Case of Acute Zonal Occult Outer Retinopathy in which Oct en Face Imaging Was Useful for Diagnosis and Follow-up
Acta Med Okayama. 2023 Aug;77(4):433-437. doi: 10.18926/AMO/65756.ABSTRACTA 23-year-old woman presented with a 1-month history of visual abnormalities in her right eye. A visual field test revealed temporal abnormalities in the right eye. Optical coherence tomography revealed an indistinct ellipsoid zone (EZ) on the B-scan image and hyporeflective areas in the EZ layer on the en face image in the right eye. We diagnosed the patient with acute zonal occult outer retinopathy. Visual field tests and B-scan images improved to almost normal at 6 months, but hyporeflective areas remained on the en face images. Thus, en face imag...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Ryuki Ono Yusuke Shiode Shuhei Kimura Mio Hosokawa Ryo Matoba Yuki Kanzaki Hiroya Kindo Tetsuro Morita Yuki Morizane Source Type: research
An Unusual Presentation of Chest Pain and Laryngeal Discomfort in a Pregnant Woman: A Case Report and Literature Review
Acta Med Okayama. 2023 Aug;77(4):429-431. doi: 10.18926/AMO/65755.ABSTRACTIntramural esophageal dissection (IED), characterized by bleeding into the submucosal space, leads to mucosal separation and dissection. The most prevalent symptoms are sudden chest or retrosternal pain, hematemesis, and dysphagia. Therefore, acute coronary syndrome and aortic dissection are among its most notable differential diagnoses. A 31-year-old pregnant woman presented with acute chest pain, laryngeal discomfort, and hematemesis. Emergency esophagogastroscopy revealed longitudinal mucosal dissection (upper esophagus to esophagogastric junction...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Misa Sasanami Atsuyoshi Iida Masaya Iwamuro Ryousuke Hirai Takashi Obara Kohei Tsukahara Tetsuya Yumoto Hiromichi Naito Atsunori Nakao Source Type: research
Acute Coronary Spasm Following Pelvic Fracture, Bleeding, and Shock in a Trauma Patient
We report a case of a patient with severe pelvic fracture who showed concurrent ST elevation on electrocardiogram. A 70-year-old man incurred an unstable pelvic fracture from a motorcycle accident. On admission, he was hemodynamically unstable, and massive transfusion and noradrenaline were administered immediately. Although ST elevation was present in leads II, III, aVF, V5, and V6, cardiac function was preserved; thus, trans-arterial embolization and external fixation for pelvic fracture were given priority. Four days after the injury, he suffered a cardiac arrest, and coronary angiography revealed that the cause of ST e...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Yasuaki Yamakawa Kohei Miyashita Atsushi Morizane Masato Takeuchi Yuta Kawashima Tomoko Sugimura Yuichi Saisaka Source Type: research
Immunohistochemical Expression of Placental Vitamin D Receptors in Pregnancies Complicated by Early and Late-Onset Preeclampsia
Acta Med Okayama. 2023 Aug;77(4):415-422. doi: 10.18926/AMO/65752.ABSTRACTThe aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclamp...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Dzenis Jelcic Velibor Puzovic Benjamin Benzon Ivan Palada Jelena Jerkovi ć Marko Vulic Source Type: research
Usefulness of Force-Controlled Pelvic Stress Radiograph in the Evaluation and Treatment of Fragility Fractures of the Pelvis in Geriatric Patients: A Pilot Study
This study aimed to investigate the usefulness of force-controlled pelvic stress radiographs in the evaluation and treatment of fragility fractures of the pelvis (FFP) using a functional treatment strategy. We conducted a retrospective study of 55 geriatric patients with FFP who underwent pelvic stress radiographs on admission. The differences in the sacral width, pelvic ring width, and medial femoral head width between the radiographs with and without the Sam Sling II M size were defined as Δ sacral width, Δ pelvic ring width, and Δ medial femoral head width, respectively. We used Pearson's correlation test to assess t...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Kensuke Hotta Takaomi Kobayashi Source Type: research
Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia
Acta Med Okayama. 2023 Aug;77(4):395-405. doi: 10.18926/AMO/65750.ABSTRACTWe investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected betwee...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Marko Pavlovic Dragan Babic Pejana Rastovic Jurica Arapovic Marko Martinac Sanja Jakovac Romana Barbaric Source Type: research
Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan
Acta Med Okayama. 2023 Aug;77(4):387-394. doi: 10.18926/AMO/65749.ABSTRACTNo epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants' bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both t...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Takahiro Kataoka Hiroshi Habu Ayumi Tanaka Shota Naoe Kaito Murakami Yuki Fujimoto Ryohei Yukimine Soshi Takao Fumihiro Mitsunobu Takashi Yorifuji Kiyonori Yamaoka Source Type: research
Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients
This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers - the FIB-4 index and APRI score - were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed signif...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Kosaku Morimoto Yasuto Takeuchi Akinobu Takaki Nozomu Wada Atsushi Oyama Takuya Adachi Hideki Onishi Hidenori Shiraha Hiroyuki Okada Source Type: research
Relationship between the Arthroscopic Findings and Pathology of Greater Trochanteric Pain Syndrome
Acta Med Okayama. 2023 Aug;77(4):371-375. doi: 10.18926/AMO/65746.ABSTRACTIn recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 ...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Yosuke Iwamoto Mitsunori Kaya Hiroaki Kijima Masashi Fujii Itsuki Nagahata Naohisa Miyakoshi Source Type: research
GATA4 rs61277615, rs73203482, and rs35813172 in Newborns with Transposition of the Great Arteries
Acta Med Okayama. 2023 Aug;77(4):365-370. doi: 10.18926/AMO/65745.ABSTRACTCongenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) we...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Elena Moldovan Claudia B ănescu Manuela Cucerea Valeriu Moldovan Liliana Gozar Lucian Pu șcașiu Source Type: research
Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve
Acta Med Okayama. 2023 Aug;77(4):359-364. doi: 10.18926/AMO/65741.ABSTRACTPulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the ...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Tomohiro Koshida Toyoaki Maruta Nobuhiko Tanaka Kotaro Hidaka Mio Kurogi Takayuki Nemoto Toshihiko Yanagita Ryu Takeya Isao Tsuneyoshi Source Type: research
Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients
In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.PMID:37635134 | DOI:10.18926/AMO/65740
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Masaya Iwamuro Takumi Kondo Daisuke Ennishi Nobuharu Fujii Ken-Ichi Matsuoka Takahide Takahashi Araki Hirabata Takehiro Tanaka Fumio Otsuka Yoshinobu Maeda Hiroyuki Okada Source Type: research
Biological Roles of Hepatitis B Viral X Protein in the Viral Replication and Hepatocarcinogenesis
Acta Med Okayama. 2023 Aug;77(4):341-345. doi: 10.18926/AMO/65739.ABSTRACTHepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral r...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Motoyuki Otsuka Source Type: research
A Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis
Acta Med Okayama. 2023 Aug;77(4):439-442. doi: 10.18926/AMO/65757.ABSTRACTA three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This sugge...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Takahiro Shiwaku Hisashi Ishida Yasuhisa Tatebe Kosuke Tamefusa Motoharu Ochi Kaori Fujiwara Toshihide Kubo Eiji Nakata Kana Washio Hirokazu Tsukahara Source Type: research
