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Specialty: Molecular Biology
Source: J Cell Mol Med

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Total 66 results found since Jan 2013.

HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.
Abstract Stroke is the leading cause of disability worldwide. HSPA12B, a heat-shock protein recently identified expression specifically in endothelial cells, is able to promote angiogenesis. Here, we have investigated its effects on functional recovery at chronic phase of ischaemic stroke. Ischaemic stroke was induced by 60 min. of middle cerebral artery occlusion in transgenic mice with overexpression of HSPA12B (HSPA12B Tg) and wild-type littermates (WT). HSPA12B Tg mice demonstrated a significant higher survival rate than WT mice within 28 days post-stroke. Significant improved neurological functions, increased...
Source: J Cell Mol Med - February 7, 2018 Category: Molecular Biology Authors: Zhao Y, Liu C, Liu J, Kong Q, Mao Y, Cheng H, Li N, Zhang X, Li C, Li Y, Liu L, Ding Z Tags: J Cell Mol Med Source Type: research

LncRNA SNHG6 functions as a ceRNA to regulate neuronal cell apoptosis by modulating miR-181c-5p/BIM signalling in ischaemic stroke.
This study aimed to examine the functional role of SNHG6 in the ischaemic stroke. Middle cerebral artery occlusion (MCAO) in mice and the oxygen glucose deprivation (OGD)-induced injury in neuronal cells were applied to mimic ischaemic stroke. TTC staining, quantitative real-time PCR, cell apoptosis assay, caspase-3 activity assay, Western blot, RNA immunoprecipitation and luciferase reporter assay were performed to evaluate the function and possible mechanisms of SNHG6 in the pathogenesis of ischaemic stroke. The results show that SNHG6 expression was significantly increased both OGD-induced neuronal cells and MCAO model ...
Source: J Cell Mol Med - July 22, 2019 Category: Molecular Biology Authors: Zhang X, Liu Z, Shu Q, Yuan S, Xing Z, Song J Tags: J Cell Mol Med Source Type: research

Differential value of intima thickness in ischaemic stroke due to large-artery atherosclerosis and small-vessel occlusion
This study aimed to assess whether intima thickness of carotid artery (CIT), radial artery (RIT) and dorsalis pedis artery (PIT) have an independent and additive value in differentiating ischaemic stroke subtypes due to large-artery atherosclerosis (LAA) or small-vessel occlusion (SVO). One hundred and sixty-one patients with LAA and 79 patients with SVO were recruited. CIT, RIT and PIT were measured with a 24-MHz ultrasound transducer. Binary logistic regression analysis was used to evaluate the differential values of the different parameters in the two subtypes. ROC curve analyses were plotted to compare the differential...
Source: J Cell Mol Med - August 30, 2021 Category: Molecular Biology Authors: Suqin Jin Cheng Zhang Yun Zhang Guoyong Jia Mei Zhang Mingjun Xu Source Type: research

Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials
J Cell Mol Med. 2022 Jan 17. doi: 10.1111/jcmm.17189. Online ahead of print.ABSTRACTMitochondrial damage is a critical contributor to stroke-induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal survival via various adaptive responses for preserving mitochondria structure, morphology, quantity and function. The processes of mitochondrial fission and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of m...
Source: J Cell Mol Med - January 18, 2022 Category: Molecular Biology Authors: Heyan Tian Xiangyu Chen Jun Liao Tong Yang Shaowu Cheng Zhigang Mei Jinwen Ge Source Type: research

Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients.
This study was performed in acute stroke patients in the Turkish population to determine the frequency of the A1166C polymorphism in the AT1 gene and to examine the role of this polymorphism in acute stroke development. In this study, 257 genomic DNA samples were analysed (from 206 acute stroke patients and 51 healthy individuals). Genomic DNA was prepared from peripheral blood using the salt-extraction method. The presence of the A1166C polymorphism in the AT1 gene was determined using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. PCR products were separated by 2% agarose gel ...
Source: J Cell Mol Med - April 1, 2013 Category: Molecular Biology Authors: Hulyam K, Aysegul B, Veysi GH, Demet O, Irfan D, Ertugrul C, Didem CT, Banu B, Miris D Tags: J Cell Mol Med Source Type: research

Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular  unit in rats after photothrombotic stroke.
Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke. J Cell Mol Med. 2018 Nov 12;: Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Abstract The remodelling of structural and functional neurovascular unit (NVU) becomes a central therapeutic strategy after cerebral ischaemic stroke. In the present study, we investigated the effect of combined therapy of sodium ferulate (SF), n-butylidenephthalide (BP) and adipose-derived stromal cells (ADSCs) to ameliorate the injured NVU in the ph...
Source: J Cell Mol Med - November 12, 2018 Category: Molecular Biology Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Tags: J Cell Mol Med Source Type: research

The role and therapeutic potential of heat shock proteins in haemorrhagic stroke.
Abstract Heat shock proteins (HSPs) are induced after haemorrhagic stroke, which includes subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH). Most of these proteins function as neuroprotective molecules to protect cerebral neurons from haemorrhagic stroke and as markers to indicate cellular stress or damage. The most widely studied HSPs in SAH are HSP70, haeme oxygenase-1 (HO-1), HSP20 and HSP27. The subsequent pathophysiological changes following SAH can be divided into two stages: early brain injury and delayed cerebral ischaemia, both of which determine the outcome for patients. Because the mech...
Source: J Cell Mol Med - July 4, 2019 Category: Molecular Biology Authors: Shao A, Zhou Y, Yao Y, Zhang W, Zhang J, Deng Y Tags: J Cell Mol Med Source Type: research

Serum tissue inhibitor of metalloproteinase-1 and risk of cognitive impairment after acute ischaemic stroke.
Abstract The expression of tissue inhibitor metalloproteinase-1 (TIMP-1) significantly increased after acute cerebral ischaemia and involved in neurodegeneration. The purpose was to prospectively investigate the relationship between serum TIMP-1 with post-stroke cognitive impairment. Our participants were from an ancillary study of China Antihypertensive Trial in Acute Ischemic Stroke. 598 ischaemic stroke patients from seven participating hospitals were included. Cognitive impairment was evaluated using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at 3 months. 316 (52.84%) or 384...
Source: J Cell Mol Med - May 19, 2020 Category: Molecular Biology Authors: Ge J, Li R, Yuan P, Che B, Bu X, Shao H, Xu T, Ju Z, Zhang J, Zhang Y, Zhong C Tags: J Cell Mol Med Source Type: research

Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke.
Abstract Microglia are rapidly activated following ischaemic stroke and participate in the induction of neuroinflammation, which exacerbates the injury of ischaemic stroke. However, the mechanisms regulating ischaemic microglia remain unclear. In the present study, middle cerebral artery occlusion and oxygen and glucose deprivation models were established for in vivo and vitro monitoring of experimental stroke. We applied recombinant human thioredoxin-1 (rhTrx-1) and Necrostatin-1 (Nec-1, inhibitor of RIPK1) to examine the role of receptor-interacting protein kinase 1 (RIPK1) in the development of inflammation in ...
Source: J Cell Mol Med - September 28, 2020 Category: Molecular Biology Authors: Jiao Y, Wang J, Zhang H, Cao Y, Qu Y, Huang S, Kong X, Song C, Li J, Li Q, Ma H, Lu X, Wang L Tags: J Cell Mol Med Source Type: research

Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network
In this study, a total of 30 participants were recruited, including 10 controls, 10 patients with AF and 10 patients with AF and stroke (AF + STROKE). Differentially expressed genes (DEGs) were identified, and functional annotation of DEGs, comparative toxicogenomic database analysis associated with cardiovascular diseases, and predictions of miRNAs of hub genes were performed. Using RT-qPCR, biological process and support vector machine neural networks, numerous DEGs were found to be related to AF. HBG1, SNCA and GYPB were found to be upregulated in the AF group. Higher expression of hub genes in AF and AF + STROKE groups...
Source: J Cell Mol Med - February 9, 2022 Category: Molecular Biology Authors: Xiang Wang Xuyang Meng Lingbing Meng Ying Guo Yi Li Chenguang Yang Zuowei Pei Jiahan Li Fang Wang Source Type: research

D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke.
Abstract Blood-brain barrier (BBB) integrity injury within the thrombolytic time window is becoming a critical target to reduce haemorrhage transformation (HT). We have previously reported that BBB damage was initially damaged in non-infarcted striatum after acute ischaemia stroke. However, the underlying mechanism is not clear. Since acute ischaemic stroke could induce a significant increase of dopamine release in striatum, in current study, our aim is to investigate the role of dopamine receptor signal pathway in BBB integrity injury after acute ischaemia using rat middle cerebral artery occlusion model. Our dat...
Source: J Cell Mol Med - July 5, 2020 Category: Molecular Biology Authors: Wang Y, Wang X, Zhang X, Chen S, Sun Y, Liu W, Jin X, Zheng G Tags: J Cell Mol Med Source Type: research

Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway.
In this study, we used the tMCAO mice model to investigate the role of circCCDC9 in the pathogenesis of stroke. We found that the expression of circCCDC9 was significantly decreased in the brains of tMCAO mice. The Evens blue and brain water content were significantly higher in the Pre-IR and Pre-IR+Vector mice, while these patterns were partially reversed by overexpression of circCCDC9. The nitrite content and eNOS expression were decreased in the Pre-IR and Pre-IR+Vector groups, which was restored by circCCDC9 overexpression. Overexpression of circCCDC9 also inhibited the expression of Caspase-3, Bax/Bcl-2 ratio and the ...
Source: J Cell Mol Med - October 29, 2020 Category: Molecular Biology Authors: Wu L, Xu H, Zhang W, Chen Z, Li W, Ke W Tags: J Cell Mol Med Source Type: research